Recent Insights into the Cellular Biology of Vascular Diseases

Dear Colleagues,

Cardiovascular diseases are the leading cause of morbidity and mortality worldwide, and the most important contribution of vascular biology is to the treatment of cardiovascular diseases. During the last few decades, major research efforts have been undertaken to understand the cellular pathophysiology of various vascular diseases. The vascular system is necessary for the homeostasis of each cell of the organism, and the blood flow distribution within an organism is dynamically regulated to match the changing metabolic demand. Not only is the amount of blood flow through different territories regulated according to demand, but the vascular wall constitutes a regulated barrier for the transport or exclusion of small metabolites, proteins, and circulating blood cells. The vessel wall is mainly made of smooth muscle cells and endothelial cells, and the coordination of endothelial and smooth muscle cell function does not rely solely on the intercellular signaling generated in a particular vessel segment, but also on the longitudinal communication along the whole vessel length. Therefore, a thorough analysis of the changes in cellular signaling is required to understand the morphological and functional modifications observed in diverse pathological and clinical conditions.

This Special Issue on “Recent Insights into the Cellular Biology of Vascular Diseases” invites original research papers and comprehensive reviews on the role of multiple signaling pathways in the progression of vascular diseases such as atherosclerosis, hypertension, aneurysm, coronary artery disease, stroke, vascular calcification, and arteriovenous malformations.

Dr. Nikhlesh Singh
Guest Editor

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