Bioengineering, Volume 12, Issue 2

Obstructive Sleep Apnea afflicts an estimated 1 billion people worldwide. Untreated, Obstructive Sleep Apnea is linked with elevated levels of mortality, decreased quality of life and increased economic costs. However, several large population studie...

The objective of this research was to develop a coded language, similarly to Morse or Braille, via a haptic thermal interface. The method is based on the human thermal sense to receive and decode the messages, and is to be used as an alternative or c...

The interplay between nutrition, physical activity, and mental health has emerged as a frontier in bioengineering research, offering innovative pathways for enhancing cognitive function and psychological resilience. This review explores the neurobiol...

This Special Issue of Bioengineering is dedicated to the profound impact of big data and artificial intelligence (AI) in the fields of biomedical research and healthcare. In an age defined by the rapid evolution of technology, this Issue explores the...

This study proposes an innovative mathematical model for assessing microcirculation in patients with diabetic ulcers, using the ankle–brachial index (ABI). The methodology combines Bond Graph (BG) modeling and Particle Swarm Optimization (PSO),...

Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which is a serious threat to human life and health. Inflammatory and immune responses are initiated immediately after MI, and unbalanced inflamm...

Background: Socially Assistive Robots (SARs) represent an innovative approach in rehabilitation technology, significantly enhancing the support and motivation for individuals across diverse rehabilitation settings. Despite their growing utilization,...

Uniform electric field distribution in electroporation is crucial for achieving the effective localized delivery of drug molecules. Currently, in vitro electroporation studies on adherent cells lack a standardized test setup for obtaining consistent...

Carrying external loads, such as vest-borne systems, is common in occupations like firefighting and military service, yet the physiological impacts of load placement, mass, and walking conditions remain not fully understood. This study examined the e...

There is a growing need to predict the severity of vitamin D deficiency (VDD) through non-invasive methods due to its significant global health concerns. For vitamin D-level assessments, the 25-hydroxy vitamin D (25-OH-D) blood test is the standard,...

Osteoporotic fractures represent a significant public health challenge in the context of an aging global population, with the rising prevalence of osteoporosis intensifying the demand for effective fracture treatment. Restoring the structure and func...

About fifty years ago, which seems very recent, new technologies for motion analysis were being developed, promising a more detailed and precise study of the human motor system [...]

Conventionally, root canal treatment is performed when the dental pulp is severely damaged or lost due to dental trauma or bacterial endodontic infections. This treatment involves removing the compromised or infected pulp tissue, disinfecting the roo...

Thoracic aortic aneurysm (TAA) is a life-threatening peripheral vascular disease with a complex pathogenesis. Altered mitochondrial function in vascular smooth muscle cells has been implicated in TAA development. However, the link between mitochondri...

Computer-aided detection (CADe) of masses in digital breast tomosynthesis (DBT) is crucial for early breast cancer diagnosis. However, the variability in the size and morphology of breast masses and their resemblance to surrounding tissues present si...

A significant challenge that hinders advancements in medical research is the sensitive and confidential nature of patient data in available datasets. In particular, sharing patients’ facial images poses considerable privacy risks, especially wi...

The pacing pulse produced by implantable stimulators can be described as a truncated exponential decay from the starting peak amplitude, corresponding to the discharge of the output stage capacitance (reservoir and isolation capacitors, in series) al...

Determining process variances in biopharmaceutical manufacturing is challenging due to limited data availability. To address this, we introduce a Bayesian hierarchical model designed for meta-analysis of process variance. This approach can improve pr...

Organisms maintain circadian rhythms corresponding to approximately 24 h in the absence of external environmental cues, and they synchronize the phases of their autonomous circadian clocks to light–dark cycles, feeding timing, and other factors...

Intraluminal thrombus (ILT) in the abdominal aortic aneurysm (AAA) is associated with disease progression and complications. This study investigates the relationship between nitric oxide (NO) concentration and ILT in AAA patients using patient-specif...

This study presents a novel Semantic-Attention Enhanced Dynamic Swin Convolutional Block Attention Module(CBAM) Transformer (DSC-Transformer) for lymph node ultrasound image classification. The model integrates semantic feature extraction and multi-s...

Cranioplasty enables the restoration of cranial defects caused by traumatic injuries, brain tumour excisions, or decompressive craniectomies. Conventional methods rely on Computer-Aided Design (CAD) for implant design, which requires significant reso...

Identifying gender-related gait changes offers valuable insights into the role of gender in motor control. It is anticipated that more difficult gait tasks (obstacle crossing) may reveal gender-specific effects on gait parameters. The present study a...

Digital pathology images have long been regarded as the gold standard for cancer diagnosis in clinical medicine. A highly generalized digital pathological image diagnosis system can provide strong support for cancer diagnosis, help to improve the dia...

Depression is a common mental health disorder and a leading contributor to mortality and morbidity. Despite several advancements, the current screening methods have limitations in enabling the robust and automated detection of depression, thereby hin...

Intracranial aneurysms (IAs), a significant medical concern due to their prevalence and life-threatening nature, pose challenges regarding diagnosis owing to their diminutive and variable morphology. There are currently challenges surrounding automat...

Cell counting in immunocytochemistry is vital for biomedical research, supporting the diagnosis and treatment of diseases such as neurological disorders, autoimmune conditions, and cancer. However, traditional counting methods are manual, time-consum...

Background: Pressure injuries are still an important health problem worldwide, although many therapies have been applied to date. This study aimed to determine the optimal duration of external application of a 10 kV/m direct current (DC, static) elec...

On-chip microfluidics are advanced in vitro models that simulate lung tissue’s native 3D environment more closely than static 2D models to investigate the complex lung architecture and multifactorial processes that lead to pulmonary disease. Cu...

Cystic echinococcosis (CE) is a chronic parasitic disease characterized by slow progression and non-specific clinical symptoms, often leading to delayed diagnosis and treatment. Early and precise diagnosis is crucial for effective treatment, particul...

Artificial Intelligence (AI) is reshaping healthcare through advancements in clinical decision support and diagnostic capabilities. While human expertise remains foundational to medical practice, AI-powered tools are increasingly matching or exceedin...

Introduction: After myocardial infarction (MI), the heart undergoes necrosis, inflammation, scar formation, and remodeling. While restoring blood flow is crucial, it can cause ischemia-reperfusion (IR) injury, driven by reactive oxygen species (ROSs)...

Background: Regeneration in the case of major burn subjects must involve tissue and structural regeneration, but also functional regeneration, as scars derived from burns often compromise motility. Electromagnetic fields and electrical stimulation ma...

This study evaluates the influence of conventional versus simplified drilling protocols on bone remodeling after the osteointegration period, marginal bone loss (MBL), and primary implant stability. A randomized, double-blind clinical trial was condu...

Artificial Intelligence (AI) has the potential to revolutionize cytopathology by enhancing diagnostic accuracy, efficiency, and accessibility. However, the implementation of AI in this field presents significant challenges and opportunities. This rev...

Background: The physicochemical changes of the surface aim to improve cell adhesion, proliferation, and differentiation, that is, better biological interaction with the cells and, consequently, with the peri-implant tissues. In the present study, imp...

Proof-of-concept to determine the direct biomechanical effects of cardiac contractility modulation (CCM) on living myocardial slices (LMS) from patients with end-stage heart failure (HF). Left ventricular LMS from patients with end-stage HF were prod...

Peri-prosthetic joint infection (PJI) is a major post-arthroplasty complication that warrants alternative antibacterial approaches to improve prophylaxis and treatment outcomes. Local administration of analgesics post-surgery is common. Recent studie...

The stability of the tibial component in Total Knee Arthroplasty (TKA) is critical to preventing aseptic loosening, a major cause of implant failure. However, existing tibial stem designs often lead to stress shielding and bone resorption, highlighti...

Objectives: Anthropomorphic phantoms offer a promising solution to minimize animal testing, enable medical training, and support the efficient development of medical devices. The adjustable mechanical, biochemical, and imaging properties of the polyv...

In this study, thin mouse kidney sections from healthy mice and those infected leading to acute and chronic sepsis were examined with two-photon excited fluorescence lifetime imaging (2P-FLIM) using the endogenous fluorescent coenzymes nicotinamide a...

The locking mechanism of the fixed-bearing tibial insert is a crucial factor in total knee arthroplasty. Previous studies have predominantly been retrieval-based, with no research examining the forces required for disassembly and assembly based on th...

Over the past decade, deep learning techniques, particularly neural networks, have become essential in medical imaging for tasks like image detection, classification, and segmentation. These methods have greatly enhanced diagnostic accuracy, enabling...

Objective: Named entity recognition (NER) offers a powerful method for automatically extracting key clinical information from text, but current models often lack sufficient support for non-English languages. Materials and Methods: This study investig...

This study applied machine learning (ML) algorithms to predict health-related quality of life (HRQOL) using comprehensive social determinants of health (SDOH) features. Data from the All of Us dataset, comprising participants with complete HRQOL and...

Anterior cruciate ligament (ACL) rupture and patellar dislocation (PD) are common knee injuries. Dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) are widely used clinical diagnostic tools. The aim was to investigate the characteris...

This study proposes a high-frequency Pulse Amplitude-Modulation Temporal-Interference (PAM-TI) current stimulation device, which utilizes two sets of Amplitude-modulated transcranial alternating current stimulation (AM-tACS): one AM frequency at f0 (...

Artificial intelligence (AI) is a growing area of computer science that combines technologies with data science to develop intelligent, highly computation-able systems. Its ability to automatically analyze and query huge sets of data has rendered it...

Jump rope is a widely applied basic training technique in various sports, yet it is understudied biomechanically. This study investigates the impact of cycle-tempo-induced motor control changes in elite jump rope athletes, addressing the biomechanica...

In the original publication [...]