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Toxics, Volume 5, Issue 4

December 2017 - 16 articles

Cover Story: Ethanol exposure during embryogenesis produces developmental defects including congenital heart defects that resemble defects seen in humans. To visualize early- and late-added cardiac precursors, a Tg(myl7:nlsKikGR) green-to-red photoconvertible protein KikGR was used, which fluoresces green but is photoconverted to red by a brief exposure to UV light. Control (left image) and ethanol exposed (right image) embryos were photoconverted at 28 hpf and imaged (three-dimensional reconstruction of confocal images) at 48 hpf, showing both red-and-green cardiomyocytes (primarily first heart field origin) and the green-only cardiomyocytes (second heart filed, cardiac neural crest origin). View the paper here.
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Articles (16)

  • Review
  • Open Access
53 Citations
9,908 Views
41 Pages

5 December 2017

Arsenic is a potent cardiovascular toxicant associated with numerous biomarkers of cardiovascular diseases in exposed human populations. Arsenic is also a carcinogen, yet arsenic trioxide is used as a therapeutic agent in the treatment of acute promy...

  • Article
  • Open Access
30 Citations
5,787 Views
17 Pages

3 December 2017

Exposure to mixtures of toxicants (e.g., pesticides) is common in real life and a subject of current concern. The present investigation was undertaken to assess some toxicological effects in male rats following exposure to methomyl (MET), abamectin (...

  • Feature Paper
  • Article
  • Open Access
15 Citations
6,510 Views
12 Pages

1 December 2017

Drinking mothers expose their fetuses to ethanol, which produces birth defects: craniofacial defects, cognitive impairment, sensorimotor disabilities and organ deformities, collectively termed as fetal alcohol spectrum disorder (FASD). Various congen...

  • Review
  • Open Access
64 Citations
11,483 Views
16 Pages

Evidence of Biomass Smoke Exposure as a Causative Factor for the Development of COPD

  • Sarah J. Capistrano,
  • David Van Reyk,
  • Hui Chen and
  • Brian G. Oliver

1 December 2017

Chronic obstructive pulmonary disease (COPD) is a progressive disease of the lungs characterised by chronic inflammation, obstruction of airways, and destruction of the parenchyma (emphysema). These changes gradually impair lung function and prevent...

  • Article
  • Open Access
3 Citations
5,568 Views
17 Pages

23 November 2017

The objective of this project was to create similar exposure groups (SEGs) for occupational monitoring in a structural steel fabrication facility. Qualitative SEG formation involved worksite observation, interviews, and audits of materials and proced...

  • Article
  • Open Access
2 Citations
4,726 Views
10 Pages

15 November 2017

Due to their very low values, the complexity of comparing the contribution of nuclear power plants (NPPs) to environmental radioactivity with modeled values is recognized. In order to compare probabilistic prognosis of radioactivity concentrations wi...

  • Article
  • Open Access
10 Citations
4,889 Views
11 Pages

10 November 2017

The concentrations of polychlorinated dibenzo-p-concentrations dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) (PCDD/Fs), and polychlorinated biphenyls (PCBs) were determined in fruit and vegetables collected in farms located in the well-known...

  • Article
  • Open Access
21 Citations
5,840 Views
10 Pages

4 November 2017

Perfluorooctanoic acid (PFOA) has been linked to negative health outcomes including cancer, thyroid disease, infertility, and developmental delays. β-Cyclodextrin (β-CD), a cyclic sugar, has been previously shown to form strong host–guest complexes w...

  • Feature Paper
  • Article
  • Open Access
53 Citations
10,595 Views
15 Pages

1 November 2017

Chemical pesticides are widely used in Cameroon for agricultural production. In 2015, more than 600 pesticide products were approved for use in various foodstuffs. Much misuse of these chemicals by farmers has been documented in rural and urban setti...

  • Review
  • Open Access
291 Citations
15,105 Views
21 Pages

17 October 2017

The development of different kinds of nanoparticles, showing different physico-chemical properties, has fostered their large use in many fields, including medicine. As a consequence, inorganic nanoparticles (e.g., metals or semiconductors), have rais...

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Toxics - ISSN 2305-6304