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Volume 14
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10.3390/foods14162820
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of Oudemansiella raphanipes

by
Zhi Wu
1,†,
Jin Zhao
1,
Shuang Zhu
2,
Mengxing Chen
2,
Dan Wu
2,
Yiyou Wu
2,
Junbin Lin
1,
Renyun Miao
1,
Rencai Feng
1,
Xiang Li
2,
Bingcheng Gan
1,2,* and
Tao Wang
1,*,†
1
Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science & Technology Center, Chengdu 610213, China
2
College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Foods 2025, 14(16), 2820; https://doi.org/10.3390/foods14162820
Submission received: 2 June 2025 / Revised: 15 July 2025 / Accepted: 12 August 2025 / Published: 14 August 2025
(This article belongs to the Special Issue Mushroom Biotechnology in Food Industry: 2nd Edition)
Versions Notes

Abstract

Oudemansiella raphanipes ethanolic extract (ORE) was prepared via ultrasonication-assisted ethanolic extraction and enriched through silica gel and macroporous adsorption resin chromatography to afford a non-/weakly polar fraction (ORE-S) and a polar fraction (ORE-N), respectively. This study aimed to (1) quantify major bioactive components (e.g., polyphenols, alkaloids, and terpenes) in ORE-S and ORE-N, (2) assess their antioxidant activities, (3) correlate compositional differences with antioxidant function, and (4) identify key antioxidant compounds along with their potential mechanisms of action. By integrating widely targeted metabolomics with network pharmacology, we not only elucidated how enrichment methods influence the antioxidant properties of ORE but also demonstrated the potential of ORE-N as a valuable source of bioactive compounds and natural antioxidants.
Keywords: Oudemansiella raphanipes; widely targeted metabolomics; antioxidant activity; enrichment approaches; network pharmacology Oudemansiella raphanipes; widely targeted metabolomics; antioxidant activity; enrichment approaches; network pharmacology

Share and Cite

MDPI and ACS Style

Wu, Z.; Zhao, J.; Zhu, S.; Chen, M.; Wu, D.; Wu, Y.; Lin, J.; Miao, R.; Feng, R.; Li, X.; et al. Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of Oudemansiella raphanipes. Foods 2025, 14, 2820. https://doi.org/10.3390/foods14162820

AMA Style

Wu Z, Zhao J, Zhu S, Chen M, Wu D, Wu Y, Lin J, Miao R, Feng R, Li X, et al. Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of Oudemansiella raphanipes. Foods. 2025; 14(16):2820. https://doi.org/10.3390/foods14162820

Chicago/Turabian Style

Wu, Zhi, Jin Zhao, Shuang Zhu, Mengxing Chen, Dan Wu, Yiyou Wu, Junbin Lin, Renyun Miao, Rencai Feng, Xiang Li, and et al. 2025. "Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of Oudemansiella raphanipes" Foods 14, no. 16: 2820. https://doi.org/10.3390/foods14162820

APA Style

Wu, Z., Zhao, J., Zhu, S., Chen, M., Wu, D., Wu, Y., Lin, J., Miao, R., Feng, R., Li, X., Gan, B., & Wang, T. (2025). Widely Targeted Metabolomic and Network Pharmacology Analyses of Active Compounds Enriched from Ethanolic Extract of Oudemansiella raphanipes. Foods, 14(16), 2820. https://doi.org/10.3390/foods14162820

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