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Inorganics, Volume 11, Issue 10

October 2023 - 44 articles

Cover Story: Two Cu(II) complexes derived from 2,3-substituted quinazolinone Schiff base ligands were prepared and fully characterized via spectroscopic and theoretical methods. Their anticancer activity, evaluated on cancer cell lines (breast—MCF-7, lung—A549) and untransformed cells (keratinocytes—HaCaT), revealed the high cytotoxicity of copper complexes (IC50 in the low micromolar range). Quinazoline ligands remained inactive in inhibiting cell proliferation. Both complexes exhibited enhanced DPPH free radical scavenging efficiency compared to free ligands. An evaluation of oxidative stress in vitro showed reduced production of O2•– and H2O2 after the treatment of cells with copper complexes. Such a negative impact on ROS formation in cells can lead to cellular redox imbalance and subsequent cell death, among other things, by inducing apoptosis and/or necrosis. View this paper
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Articles (44)

  • Article
  • Open Access
3 Citations
2,727 Views
12 Pages

Synthesis, Characterization, DNA Binding and Cytotoxicity of Copper(II) Phenylcarboxylate Complexes

  • Carlos Y. Fernández,
  • Analu Rocha,
  • Mohammad Azam,
  • Natalia Alvarez,
  • Kim Min,
  • Alzir A. Batista,
  • Antonio J. Costa-Filho,
  • Javier Ellena and
  • Gianella Facchin

11 October 2023

Coordination compounds of copper exhibit cytotoxic activity and are suitable for the search for novel drug candidates for cancer treatment. In this work, we synthesized three copper(II) carboxylate complexes, [Cu2(3-(4-hydroxyphenyl)propanoate)4(H2O)...

  • Feature Paper
  • Review
  • Open Access
12 Citations
6,487 Views
18 Pages

Recent Progress in Source/Drain Ohmic Contact with β-Ga2O3

  • Lin-Qing Zhang,
  • Wan-Qing Miao,
  • Xiao-Li Wu,
  • Jing-Yi Ding,
  • Shao-Yong Qin,
  • Jia-Jia Liu,
  • Ya-Ting Tian,
  • Zhi-Yan Wu,
  • Yan Zhang and
  • Qian Xing
  • + 1 author

11 October 2023

β-Ga2O3, with excellent bandgap, breakdown field, and thermal stability properties, is considered to be one of the most promising candidates for power devices including field-effect transistors (FETs) and for other applications such as Schottky...

  • Article
  • Open Access
3 Citations
2,222 Views
22 Pages

Anti-Proliferation and DNA Cleavage Activities of Copper(II) Complexes of N3O Tripodal Polyamine Ligands

  • Doti Serre,
  • Sule Erbek,
  • Nathalie Berthet,
  • Christian Philouze,
  • Xavier Ronot,
  • Véronique Martel-Frachet and
  • Fabrice Thomas

9 October 2023

Four ligands based on the 2-tert-butyl-4-X-6-{Bis[(6-methoxy-pyridin-2-ylmethyl)-amino]-methyl}-phenol unit are synthesized: X = CHO (HLCHO), putrescine-pyrene (HLpyr), putrescine (HLamine), and 2-tert-butyl-4-putrescine-6-{Bis[(6-methoxy-pyridin-2-y...

  • Article
  • Open Access
2 Citations
3,051 Views
14 Pages

Synthesis and X-ray Structure Analysis of the Polymeric [Ag2(4-Amino-4H-1,2,4-triazole)2(NO3)]n(NO3)n Adduct: Anticancer, and Antimicrobial Applications

  • Mostafa A. El-Naggar,
  • Hessa H. Al-Rasheed,
  • Sarah A. AL-khamis,
  • Ayman El-Faham,
  • Morsy A. M. Abu-Youssef,
  • Matti Haukka,
  • Assem Barakat,
  • Mona M. Sharaf and
  • Saied M. Soliman

9 October 2023

A new Ag(I) adduct was synthesized by the reaction of 4-amino-4H-1,2,4-triazole (L) with AgNO3. Its chemical structure was approved to be [Ag2(L)2(NO3)]n(NO3)n utilizing elemental analysis, FTIR spectra, and single crystal X-ray diffraction (SC-XRD)....

  • Review
  • Open Access
37 Citations
5,388 Views
23 Pages

The Importance of Being Casiopeina as Polypharmacologycal Profile (Mixed Chelate–Copper (II) Complexes and Their In Vitro and In Vivo Activities)

  • Zenayda Aguilar-Jiménez,
  • Adrián Espinoza-Guillén,
  • Karen Resendiz-Acevedo,
  • Inés Fuentes-Noriega,
  • Carmen Mejía and
  • Lena Ruiz-Azuara

7 October 2023

In this review, we present a timeline that shows the origin of mixed chelate copper (II) complexes, registered as Mark Title Casiopeínas®, as the first copper (II) compounds proposed as anticancer drugs in 1988 and 1992. In the late twenti...

  • Article
  • Open Access
2 Citations
2,331 Views
15 Pages

Interactions of Clotrimazole with Certain d-Metal Compounds and with Organic Acids

  • Nina Skorik,
  • Irina Kurzina,
  • Vladislav Korostelev,
  • Dmitriy Fedorishin and
  • Vladimir Kozik

5 October 2023

During the interaction of aqueous-ethanol or ethanol solutions AgNO3, H[AuCl4], and CuCl2, as well as aqueous suspensions of slightly soluble copper(II) salts Cu(C6H4NO2)2·H2O, Cu(C7H5O2)2∙3H2O, and CuC7H4O3∙H2O with the ethanol so...

  • Article
  • Open Access
3 Citations
2,181 Views
19 Pages

3 October 2023

New sulfone 2-aminobenzimidazole derivatives were designed and synthesized. Their nickel(II), copper(II), zinc(II), cadmium(II) and mercury(II) compounds were obtained and fully characterized by spectroscopic and analytical techniques. Single crystal...

  • Article
  • Open Access
7 Citations
3,141 Views
16 Pages

Enhancement of the Cytotoxicity of Quinazolinone Schiff Base Derivatives with Copper Coordination

  • Ilona Gurgul,
  • Jana Hricovíniová,
  • Olga Mazuryk,
  • Zuzana Hricovíniová and
  • Małgorzata Brindell

2 October 2023

Two copper(II) complexes (Cu-L1, Cu-L2) derived from 2,3-substituted quinazolinone Schiff base ligands (L1, L2) were prepared to examine their anticancer activity. Compounds were characterized using various spectroscopic methods (FTIR, NMR, UV-vis) a...

  • Article
  • Open Access
14 Citations
4,918 Views
25 Pages

Thiourea Derivative Metal Complexes: Spectroscopic, Anti-Microbial Evaluation, ADMET, Toxicity, and Molecular Docking Studies

  • Ahmed T. F. Al-Halbosy,
  • Adnan A. Hamada,
  • Ahmed S. Faihan,
  • Abdulrahman M. Saleh,
  • Tarek A. Yousef,
  • Mortaga M. Abou-Krisha,
  • Mona H. Alhalafi and
  • Ahmed S. M. Al-Janabi

30 September 2023

The treatment of N-Phenylmorpholine-4-carbothioamide (HPMCT) with bivalent metal ions in a 2:1 mol ratio without a base present affords [MCl2(κ1S-HPMCT)2] {M = Cu(1), Pd(2), Pt(3), and Hg(4)} in a good yield. Furthermore, the reaction of two eq...

  • Article
  • Open Access
4 Citations
2,598 Views
10 Pages

30 September 2023

Recent advancements in the study of the protein complex photosystem II have clarified the sequence of events leading to the formation of oxygen during the S3 → S4 → S0 transition, wherein the inorganic Mn4Ca(µ-O)6(OHx)4 cluster finish...

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Inorganics - ISSN 2304-6740