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Processes, Volume 7, Issue 2

February 2019 - 64 articles

Cover Story: The anaerobic bacterium Clostridium difficile is an opportunistic pathogen responsible for chronic and sometimes life-threatening infections in the colon of the human gastrointestinal tract. C. difficile (Cd) dysbiosis is characterized by a dramatic decrease in health-promoting species from the phylum Firmicutes (represented by Faecalibacterium prausnitzii; Fp), a dramatic increase in the phylum Proteobacteria (represented by Escherichia coli; Ec), and no consistent trends in the phylum Bacteroidetes (represented by Bacteroides thetaiotaomicron; Bt). This paper addresses the problem of C. difficile expansion through the development of a biofilm metabolic model that provides spatial predictions of nutrient diffusion, species abundances, and metabolite cross-feeding. View this paper.
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Articles (64)

  • Feature Paper
  • Article
  • Open Access
4 Citations
5,127 Views
18 Pages

Scheduling of Energy-Integrated Batch Process Systems Using a Pattern-Based Framework

  • Sujit Suresh Jogwar,
  • Shrikant Mete and
  • Channamallikarjun S. Mathpati

15 February 2019

In this paper, a novel pattern-based method is developed for the generation of optimal schedules for energy-integrated batch process systems. The proposed methodology is based on the analysis of available schedules for the identification of repetitiv...

  • Article
  • Open Access
8 Citations
5,226 Views
21 Pages

15 February 2019

The methodology of profile monitoring combines both the model fitting and statistical process control (SPC) techniques. Over the past ten years, a variety of profile monitoring methods have been proposed and extensively investigated in terms of diffe...

  • Article
  • Open Access
13 Citations
5,775 Views
16 Pages

14 February 2019

Chlorine-incorporating ultraviolet (UV) provides a multiple barrier for drinking water disinfection. Meanwhile, post-UV employment can promote the degradation of micropollutants by radical production from chlorine residual photolysis. This work studi...

  • Article
  • Open Access
45 Citations
6,725 Views
20 Pages

An Optimization-Based Framework to Define the Probabilistic Design Space of Pharmaceutical Processes with Model Uncertainty

  • Daniel Laky,
  • Shu Xu,
  • Jose S. Rodriguez,
  • Shankar Vaidyaraman,
  • Salvador García Muñoz and
  • Carl Laird

14 February 2019

To increase manufacturing flexibility and system understanding in pharmaceutical development, the FDA launched the quality by design (QbD) initiative. Within QbD, the design space is the multidimensional region (of the input variables and process par...

  • Article
  • Open Access
12 Citations
5,974 Views
11 Pages

Purification of Flavonoids from Mulberry Leaves via High-Speed Counter-Current Chromatography

  • Pian Zhang,
  • Kang-Ling Zhu,
  • Jun Zhang,
  • Yan Li,
  • Heng Zhang and
  • Yan Wang

13 February 2019

In order to obtain high-purity flavonoid products, the extracts from mulberry leaves were separated and purified via high-speed counter-current chromatography (HSCCC). Moreover, the product was detected via high-performance liquid chromatography (HPL...

  • Feature Paper
  • Article
  • Open Access
9 Citations
4,425 Views
12 Pages

13 February 2019

A major challenge in model-based design of synthetic biochemical circuits is how to address uncertainty in the parameters. A circuit whose behavior is robust to variations in the parameters will have more chances to behave as predicted when implement...

  • Article
  • Open Access
15 Citations
7,025 Views
24 Pages

13 February 2019

The objective of this paper is to evaluate and to simulate the cogeneration process applied to an apartment building in the Polanco area (Mexico). Considering the building’s electric, thermal demand and consumption data, the cogeneration proces...

  • Feature Paper
  • Review
  • Open Access
90 Citations
18,645 Views
28 Pages

Accelerating Biologics Manufacturing by Modeling or: Is Approval under the QbD and PAT Approaches Demanded by Authorities Acceptable without a Digital-Twin?

  • Steffen Zobel-Roos,
  • Axel Schmidt,
  • Fabian Mestmäcker,
  • Mourad Mouellef,
  • Maximilian Huter,
  • Lukas Uhlenbrock,
  • Martin Kornecki,
  • Lara Lohmann,
  • Reinhard Ditz and
  • Jochen Strube

13 February 2019

Innovative biologics, including cell therapeutics, virus-like particles, exosomes, recombinant proteins, and peptides, seem likely to substitute monoclonal antibodies as the main therapeutic entities in manufacturing over the next decades. This molec...

  • Feature Paper
  • Article
  • Open Access
25 Citations
8,500 Views
16 Pages

Phytochemical Content of Melissa officinalis L. Herbal Preparations Appropriate for Consumption

  • Vassiliki T. Papoti,
  • Nikolaos Totomis,
  • Aikaterini Atmatzidou,
  • Kyriaki Zinoviadou,
  • Anna Androulaki,
  • Dimitris Petridis and
  • Christos Ritzoulis

12 February 2019

Melissa Officinalis L. (MOL) domestic preparations appropriate for consumption were studied by monitoring content in Na, K, Ca, Li, phenolic bioactives (total phenols, hydroxycinnamic acid derivatives and flavonols), and antioxidant activity (1,1-dip...

  • Article
  • Open Access
11 Citations
5,432 Views
20 Pages

12 February 2019

With the rapid development of computer science and information and communication technology (ICT), increasingly intelligent, and complex systems have been applied to industries as well as human life. Fault-tolerant control (FTC) has, therefore, becom...

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Processes - ISSN 2227-9717