Table of Contents
Processes, Volume 7, Issue 2 (February 2019)
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Cover Story (view full-size image) The anaerobic bacterium Clostridium difficile is an opportunistic pathogen responsible for chronic [...] Read more. The anaerobic bacterium Clostridium difficile is an opportunistic pathogen responsible for chronic and sometimes life-threatening infections in the colon of the human gastrointestinal tract. C. difficile (Cd) dysbiosis is characterized by a dramatic decrease in health-promoting species from the phylum Firmicutes (represented by Faecalibacterium prausnitzii; Fp), a dramatic increase in the phylum Proteobacteria (represented by Escherichia coli; Ec), and no consistent trends in the phylum Bacteroidetes (represented by Bacteroides thetaiotaomicron; Bt). This paper addresses the problem of C. difficile expansion through the development of a biofilm metabolic model that provides spatial predictions of nutrient diffusion, species abundances, and metabolite cross-feeding. View this paper.