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Processes, Volume 6, Issue 8

2018 August - 38 articles

Cover Story: Kinetic modeling of metabolic reaction networks requires knowledge of parameters associated with every reaction in the network, including potential regulatory molecular players. Cybernetic modeling overcomes this requirement by accounting for regulation through the incorporation of the cybernetic variables, ui and vi, calculated to satisfy cellular objectives. While past cybernetic models have relied on objectives such as maximizing growth rate or carbon uptake rate, the framework here is adapted to model the dynamic behavior of biosynthesis of the inflammatory molecule prostaglandin based on maximizing the inflammatory marker cytokine, TNFα, in macrophage cells. This captures the inflammatory response to infection in bone marrow-derived macrophage cells. View this paper.
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Articles (38)

  • Feature Paper
  • Article
  • Open Access
15 Citations
7,025 Views
34 Pages

18 August 2018

Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein metab...

  • Article
  • Open Access
30 Citations
4,900 Views
16 Pages

17 August 2018

Subsection split grouting technology can effectively improve the grouting efficiency and homogeneity of grouting in a target reinforcement area. It is therefore necessary to clarify the reinforcement mechanism and characteristics of the soft filling...

  • Feature Paper
  • Article
  • Open Access
7 Citations
6,357 Views
28 Pages

17 August 2018

Cell-free protein expression has emerged as an important approach in systems and synthetic biology, and a promising technology for personalized point of care medicine. Cell-free systems derived from crude whole cell extracts have shown remarkable uti...

  • Article
  • Open Access
22 Citations
10,566 Views
20 Pages

17 August 2018

A recommender system is currently applied in many different domains, seeking to provide users with recommendation services according to their personalized preferences to relieve rising online information congestion. As the number of mobile phone user...

  • Article
  • Open Access
11 Citations
9,089 Views
19 Pages

Comparison of a Novel Miniaturized Screening Device with Büchi B290 Mini Spray-Dryer for the Development of Spray-Dried Solid Dispersions (SDSDs)

  • Aymeric Ousset,
  • Joke Meeus,
  • Florent Robin,
  • Martin Alexander Schubert,
  • Pascal Somville and
  • Kalliopi Dodou

16 August 2018

Spray-drying is an increasingly popular technology for the production of amorphous solid dispersions (ASDs) in the pharmaceutical industry that is used in the early evaluation and industrial production of formulations. Efficient screening of ASD in t...

  • Concept Paper
  • Open Access
24 Citations
5,382 Views
17 Pages

16 August 2018

The Colebrook equation is implicitly given in respect to the unknown flow friction factor λ; λ = ζ ( R e , ε * , λ ) which cannot be expressed explicitly in exact way without simplifications and use of approximate calculus. A common app...

  • Article
  • Open Access
7 Citations
4,587 Views
18 Pages

15 August 2018

The biological slow filtration (BSF) system as a simple and efficient environmental technology has been widely applied in treatment of ‘micro-polluted’ water. At present, many related studies have focused on the removal efficiency of biol...

  • Article
  • Open Access
21 Citations
5,407 Views
22 Pages

13 August 2018

Modeling the coupled evolution of strain and CH4 seepage under conventional triaxial compression is the key to understanding enhanced permeability in coal. An abrupt transition of gas-stress coupled behavior at the dilatancy boundary is studied by th...

  • Feature Paper
  • Article
  • Open Access
8 Citations
6,457 Views
15 Pages

A Cybernetic Approach to Modeling Lipid Metabolism in Mammalian Cells

  • Lina Aboulmouna,
  • Shakti Gupta,
  • Mano R. Maurya,
  • Frank T. DeVilbiss,
  • Shankar Subramaniam and
  • Doraiswami Ramkrishna

12 August 2018

The goal-oriented control policies of cybernetic models have been used to predict metabolic phenomena such as the behavior of gene knockout strains, complex substrate uptake patterns, and dynamic metabolic flux distributions. Cybernetic theory builds...

  • Article
  • Open Access
31 Citations
6,647 Views
19 Pages

11 August 2018

Using conventional coagulant, low turbidity water is difficult to achieve standard. This research uses aluminum chloride, titanium tetrachloride, and sodium silicate as raw materials for the preparation of polyaluminum titanium silicate chloride (PAT...

  • Feature Paper
  • Review
  • Open Access
21 Citations
6,894 Views
20 Pages

Computational Molecular Modeling of Transport Processes in Nanoporous Membranes

  • Kevin R. Hinkle,
  • Xiaoyu Wang,
  • Xuehong Gu,
  • Cynthia J. Jameson and
  • Sohail Murad

9 August 2018

In this report we have discussed the important role of molecular modeling, especially the use of the molecular dynamics method, in investigating transport processes in nanoporous materials such as membranes. With the availability of high performance...

  • Article
  • Open Access
15 Citations
5,727 Views
12 Pages

8 August 2018

Fluidized bed reactors have been increasingly applied for mass production of Carbon Nanotube (CNT) using catalytic chemical vapor deposition technology. Effect of particle size (dp = 131 μm and 220 μm) on fluidization characteristics and aggreg...

  • Review
  • Open Access
79 Citations
18,291 Views
22 Pages

8 August 2018

The ineffective control of the release of pollutants into water has led to serious water pollution. Compared with conditions in the past, the polluting components in aquatic environments have become increasingly complex. Some emerging substances have...

  • Article
  • Open Access
8 Citations
4,814 Views
11 Pages

Deformation and Hydraulic Conductivity of Compacted Clay under Waste Differential Settlement

  • Sifa Xu,
  • Cuifeng Li,
  • Jizhuang Liu,
  • Mengdan Bian,
  • Weiwei Wei,
  • Hao Zhang and
  • Zhe Wang

8 August 2018

Landfill is still the most important process to dispose of municipal solid waste in China, while landfill closure aims for pollution control, security control, and better land reuse. However, uneven settlement of landfill cover system is very likely...

  • Feature Paper
  • Review
  • Open Access
150 Citations
36,356 Views
16 Pages

Flotation in Water and Wastewater Treatment

  • George Z. Kyzas and
  • Kostas A. Matis

7 August 2018

Flotation constitutes a separation process that originated from mineral processing. Nowadays, wider applications have been found and compared to flotation for water and wastewater treatment. Stress in the present review paper was mainly applied to he...

  • Communication
  • Open Access
5 Citations
5,055 Views
8 Pages

A New Concept of Stirred Multiphase Reactor Using a Stationary Catalytic Foam

  • Nassima Benamara,
  • Didier Assoua,
  • Louis Jaffeux,
  • Laurent Vanoye,
  • Florica Simescu-Lazar,
  • Marie-Line Zanota,
  • Frédéric Bornette,
  • Valérie Meille and
  • Isabelle Pitault

7 August 2018

Developing new stirred gas–liquid–solid reactors with high mass transfer capabilities is still a challenge. In this publication, we present a new concept of multiphase reactor using a stationary catalytic foam and a gas-inducing impeller....

  • Feature Paper
  • Article
  • Open Access
13 Citations
5,827 Views
18 Pages

7 August 2018

Predictive functional control (PFC) is a fast and effective controller that is widely used for processes with simple dynamics. This paper proposes some techniques for improving its reliability when applied to systems with more challenging dynamics, s...

  • Feature Paper
  • Article
  • Open Access
1 Citations
4,535 Views
14 Pages

Effects of Pulse Interval and Dosing Flux on Cells Varying the Relative Velocity of Micro Droplets and Culture Solution

  • Zhanwei Wang,
  • Kun Liu,
  • Jiuxin Ning,
  • Shulei Chen,
  • Ming Hao,
  • Dongyang Wang,
  • Qi Mei,
  • Yaoshuai Ba and
  • Dechun Ba

7 August 2018

Microdroplet dosing to cell on a chip could meet the demand of narrow diffusion distance, controllable pulse dosing and less impact to cells. In this work, we studied the diffusion process of microdroplet cell pulse dosing in the three-layer sandwich...

  • Feature Paper
  • Article
  • Open Access
13 Citations
4,664 Views
20 Pages

A Coupled Thermal-Hydraulic-Mechanical Nonlinear Model for Fault Water Inrush

  • Weitao Liu,
  • Jiyuan Zhao,
  • Ruiai Nie,
  • Yuben Liu and
  • Yanhui Du

7 August 2018

A coupled thermal-nonlinear hydraulic-mechanical (THM) model for fault water inrush was carried out in this paper to study the water-rock-temperature interactions and predict the fault water inrush. First, the governing equations of the coupled THM m...

  • Feature Paper
  • Article
  • Open Access
10 Citations
5,281 Views
19 Pages

Modeling the Dynamics of Human Liver Failure Post Liver Resection

  • Babita K. Verma,
  • Pushpavanam Subramaniam and
  • Rajanikanth Vadigepalli

4 August 2018

Liver resection is an important clinical intervention to treat liver disease. Following liver resection, patients exhibit a wide range of outcomes including normal recovery, suppressed recovery, or liver failure, depending on the regenerative capacit...

  • Feature Paper
  • Article
  • Open Access
17 Citations
7,864 Views
19 Pages

3 August 2018

The increasing variability in power plant load in response to a wildly uncertain electricity market and the need to to mitigate CO2 emissions, lead power plant operators to explore advanced options for efficiency optimization. Model-based, system-sca...

  • Article
  • Open Access
12 Citations
5,906 Views
15 Pages

Effect of Pore Fluid Pressure on the Normal Deformation of a Matched Granite Joint

  • Qiang Zhang,
  • Xiaochun Li,
  • Bing Bai,
  • Shaobin Hu and
  • Lu Shi

1 August 2018

The influence of pore fluid pressure on the normal deformation behaviors of joints is vital for understanding the interaction between hydraulic and mechanical processes of joints. The effect of pore fluid pressure on the normal deformation of a grani...

  • Article
  • Open Access
11 Citations
6,396 Views
12 Pages

Fabrication of New Liquid Crystal Device Using Layer-by-Layer Thin Film Process

  • Gitae Moon,
  • Wonjun Jang,
  • Intae Son,
  • Hyun A. Cho,
  • Yong Tae Park and
  • Jun Hyup Lee

1 August 2018

Indium tin oxide (ITO) transparent electrodes are troubled with high cost and poor mechanical stability. In this study, layer-by-layer (LBL)-processed thin films with single-walled carbon nanotubes (SWNTs) exhibited high transparency and electrical c...

  • Case Report
  • Open Access
7 Citations
5,791 Views
13 Pages

1 August 2018

The mega debris flow that occurred on 13 August 2010 in Zoumaling Valley in Mianzhu County, China has done great damage to the local inhabitants, as well as to the re-construction projects in the quake-hit areas. Moreover, it is of high possibility t...

  • Article
  • Open Access
22 Citations
5,087 Views
23 Pages

Experimental Study on the Creep Characteristics of Coal Measures Sandstone under Seepage Action

  • Ziheng Sha,
  • Hai Pu,
  • Ming Li,
  • Lili Cao,
  • Ding Liu,
  • Hongyang Ni and
  • Jingfeng Lu

1 August 2018

The seepage action of underground water accelerates the deformation of roadway surrounding rock in deep mines. Therefore, the study of creep characteristics of surrounding rock under seepage action is the basis for the stability control of roadway su...

  • Article
  • Open Access
11 Citations
4,507 Views
22 Pages

1 August 2018

One major challenge in modeling Darcy flow in heterogeneous porous media is simulating the material interfaces accurately. To overcome this defect, the refraction law is fully introduced into the numerical manifold method (NMM) as an a posteriori con...

  • Article
  • Open Access
15 Citations
6,924 Views
14 Pages

1 August 2018

Ion exchange and cementation experiments were done to separate silver(I) from a raffinate containing silver(I), nickel(II), and zinc(II) and small amounts of copper(II) and tin(II). The raffinate resulted from the recovery of gold(III), tin(II) and c...

  • Article
  • Open Access
49 Citations
9,550 Views
25 Pages

1 August 2018

To investigate the mechanism of hydraulic fracture propagation in coal seams with discontinuous natural fractures, an innovative finite element meshing scheme for modeling hydraulic fracturing was proposed. Hydraulic fracture propagation and interact...

  • Feature Paper
  • Article
  • Open Access
317 Citations
33,176 Views
26 Pages

GEKKO Optimization Suite

  • Logan D. R. Beal,
  • Daniel C. Hill,
  • R. Abraham Martin and
  • John D. Hedengren

31 July 2018

This paper introduces GEKKO as an optimization suite for Python. GEKKO specializes in dynamic optimization problems for mixed-integer, nonlinear, and differential algebraic equations (DAE) problems. By blending the approaches of typical algebraic mod...

  • Article
  • Open Access
9 Citations
3,860 Views
15 Pages

30 July 2018

Knowledge of the bedding plane properties of coal seams is essential for the coalbed gas production because of their great influence on the inner flow characteristics and sorption features of gas and water. In this study, an experimental study on the...

  • Article
  • Open Access
11 Citations
6,501 Views
15 Pages

30 July 2018

Stevia rebaudiana Bertoni is a perennial shrub belonging to the Asteraceae family. The leaves contain a mixture of steviol glycosides with extraordinary sweetening properties, among which the most important are stevioside and rebaudioside A. These co...

  • Article
  • Open Access
26 Citations
5,289 Views
22 Pages

29 July 2018

Normally, most of the accidents that occur in underground facilities are not instantaneous; rather, hazards build up gradually behind the scenes and are invisible due to the inherent structure of these facilities. An efficient inference system is hig...

  • Article
  • Open Access
3 Citations
5,088 Views
16 Pages

The Role of Immune Response in Optimal HIV Treatment Interventions

  • Hernán Darío Toro-Zapata,
  • Angélica Caicedo-Casso and
  • Sunmi Lee

26 July 2018

A mathematical model for the transmission dynamics of human immunodeficiency virus (HIV) within a host is developed. Our model focuses on the roles of immune response cells or cytotoxic lymphocytes (CTLs). The model includes active and inactive cytot...

  • Article
  • Open Access
77 Citations
5,337 Views
20 Pages

25 July 2018

Hot dry rock is developed by injecting cold water into high-temperature rock mass. At the same time, cold water is heated in contact with the rock mass. With the continuous influx of cold water, the surrounding rock will undergo a rapid cooling proce...

  • Article
  • Open Access
10 Citations
6,333 Views
18 Pages

24 July 2018

Systems composed of many components which interact with each other and lead to unpredictable global behaviour, are considered as complex systems. In a biological context, complex systems represent living systems composed of a large number of interact...

  • Article
  • Open Access
64 Citations
9,955 Views
50 Pages

24 July 2018

A complete bibliometric analysis of the Scopus database was performed to identify the research trends related to lignin valorization from 2000 to 2016. The results from this analysis revealed an exponentially increasing number of publications and a h...

  • Article
  • Open Access
5 Citations
5,025 Views
19 Pages

24 July 2018

The microstructures of rock gradually evolve with changes in the external environment. This study focused on the microstructure evolution of glauberite and its weakening mechanism under different leaching conditions. The porosity were used as a chara...

  • Article
  • Open Access
16 Citations
4,778 Views
12 Pages

24 July 2018

Due to the complicated metabolism of mammalian cells, the corresponding dynamic mathematical models usually consist of large sets of differential and algebraic equations with a large number of parameters to be estimated. On the other hand, the measur...

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Processes - ISSN 2227-9717