Next Article in Journal
A Coupled Thermal-Hydraulic-Mechanical Nonlinear Model for Fault Water Inrush
Next Article in Special Issue
Computational Molecular Modeling of Transport Processes in Nanoporous Membranes
Previous Article in Journal
Input Shaping Predictive Functional Control for Different Types of Challenging Dynamics Processes
Previous Article in Special Issue
The Influence of Cation Treatments on the Pervaporation Dehydration of NaA Zeolite Membranes Prepared on Hollow Fibers
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessFeature PaperArticle
Processes 2018, 6(8), 119; https://doi.org/10.3390/pr6080119

Effects of Pulse Interval and Dosing Flux on Cells Varying the Relative Velocity of Micro Droplets and Culture Solution

1
School of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China
2
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
*
Authors to whom correspondence should be addressed.
Received: 28 June 2018 / Revised: 2 August 2018 / Accepted: 3 August 2018 / Published: 7 August 2018
(This article belongs to the Special Issue Transport of Fluids in Nanoporous Materials)
Full-Text   |   PDF [2905 KB, uploaded 7 August 2018]   |  

Abstract

Microdroplet dosing to cell on a chip could meet the demand of narrow diffusion distance, controllable pulse dosing and less impact to cells. In this work, we studied the diffusion process of microdroplet cell pulse dosing in the three-layer sandwich structure of PDMS (polydimethylsiloxane)/PCTE (polycarbonate) microporous membrane/PDMS chip. The mathematical model is established to solve the diffusion process and the process of rhodamine transfer to micro-traps is simulated. The rhodamine mass fraction distribution, pressure field and velocity field around the microdroplet and cell surfaces are analyzed for further study of interdiffusion and convective diffusion effect. The cell pulse dosing time and drug delivery efficiency could be controlled by adjusting microdroplet and culture solution velocity without impairing cells at micro-traps. Furthermore, the accuracy and controllability of the cell dosing pulse time and maximum drug mass fraction on cell surfaces are achieved and the drug effect on cells could be analyzed more precisely especially for neuron cell dosing. View Full-Text
Keywords: cell dosing; microdroplet; convective diffusion; interdiffusion; numerical simulation cell dosing; microdroplet; convective diffusion; interdiffusion; numerical simulation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Wang, Z.; Liu, K.; Ning, J.; Chen, S.; Hao, M.; Wang, D.; Mei, Q.; Ba, Y.; Ba, D. Effects of Pulse Interval and Dosing Flux on Cells Varying the Relative Velocity of Micro Droplets and Culture Solution. Processes 2018, 6, 119.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Processes EISSN 2227-9717 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top