Chromatography, Volume 1, Issue 2

2014 June - 4 articles

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Article

19 Citations

9,249 Views

14 Pages

A Sensitive and Robust Ultra HPLC Assay with Tandem Mass Spectrometric Detection for the Quantitation of the PARP Inhibitor Olaparib (AZD2281) in Human Plasma for Pharmacokinetic Application

Jeffrey Roth,
Cody J. Peer,
Baskar Mannargudi,
Helen Swaisland,
Jung-Min Lee,
Elise C. Kohn and
William D. Figg

Chromatography2014, 1(2), 82-95;https://doi.org/10.3390/chromatography1020082

19 June 2014

Olaparib (AZD2281) is an orally active PARP-1 inhibitor, primarily effective against cancers with BRCA1/2 mutations. It is currently in Phase III development and has previously been investigated in numerous clinical trials, both as a single agent an...

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Article

6 Citations

7,459 Views

7 Pages

An Isocratic Toxic Chemical-Free Mobile Phase HPLC-PDA Analysis of Malachite Green and Leuco-Malachite Green

Naoto Furusawa

Chromatography2014, 1(2), 75-81;https://doi.org/10.3390/chromatography1020075

27 May 2014

This paper describes a reserved-phase high-performance liquid chromatographic (HPLC) method for detecting malachite green (MG) and leuco-malachite green (LMG) using an isocratic toxic organic solvent/reagent-free mobile phase. Chromatographic separat...

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Article

1 Citations

6,498 Views

10 Pages

Influence of the Azulene Ring on the Enantioseparation of 1,5-Diols

Dana A. Horgen and
Charles M. Garner

Chromatography2014, 1(2), 65-74;https://doi.org/10.3390/chromatography1020065

16 May 2014

The enantioseparation of a series of six azulene-centered 1,5-diol enantiomers was studied employing two cellulose-based chiral stationary phases under normal phase conditions (isopropanol/hexanes). The separations were generally quite good on Chira...

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Article

2 Citations

8,296 Views

10 Pages

Adaptation of a High-Pressure Liquid Chromatography System for the Measurement of Viscosity

Sonia Gregory and
Henryk Mach

Chromatography2014, 1(2), 55-64;https://doi.org/10.3390/chromatography1020055

26 March 2014

The state-of-the-art instruments for the determination of viscosity of liquids typically require a significant amount of sample, and have relatively low throughput due to manual and sequential measurements. In this study, it was demonstrated that the...

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