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Chemosensors, Volume 13, Issue 6

2025 June - 28 articles

Cover Story: Early-stage detection of gastric cancer is crucial, as late diagnosis remains a major cause of mortality. Tumor biomarkers such as CA12-5, CA72-4, HER1, and AFP offer valuable insights for diagnosis and treatment monitoring. This study presents three novel 3D stochastic sensors using graphite, graphene, and nanographene modified with an oleamide for the simultaneous detection and quantification of these four biomarkers in whole blood, saliva, urine, and gastric tumor tissue. The graphene-based sensor showed the best performance, with high sensitivity, wide linear ranges, and an RSD below 1%, offering a promising tool for fast, multiplexed, and point-of-care cancer screening. View this paper
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Articles (28)

  • Review
  • Open Access
2 Citations
2,949 Views
33 Pages

Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis

  • Stephen Rathinaraj Benjamin,
  • Fábio de Lima,
  • Paulo Iury Gomes Nunes,
  • Rosa Fireman Dutra,
  • Geanne Matos de Andrade and
  • Reinaldo B. Oriá

Diagnosing Alzheimer’s disease (AD) remains a significant challenge due to its multifactorial nature and the limitations of traditional diagnostic methods, such as clinical assessments and neuroimaging, which often lack the specificity and sens...

  • Article
  • Open Access
2 Citations
1,613 Views
19 Pages

Chemical nanosensors based on tin dioxide (SnO2) and zinc oxide (ZnO) nanoparticles (NPs) were developed and characterized for the detection of low concentrations of atmospheric pollutants, such as nitrogen dioxide (NO2) and carbon monoxide (CO). The...

  • Article
  • Open Access
2 Citations
4,288 Views
18 Pages

Trimethylamine Gas Sensor Based on Electrospun In2O3 Nanowires with Different Grain Sizes for Fish Freshness Monitoring

  • Xiangrui Dong,
  • Bo Zhang,
  • Mengyao Shen,
  • Qi Lu,
  • Hao Shen,
  • Yi Ni,
  • Yuechen Liu and
  • Haitao Song

Seafood, especially marine fish, is highly prone to spoilage during processing, transportation, and storage. It releases pungent trimethylamine (TMA) gas, which severely affects food quality and safety. Metal–oxide–semiconductor (MOS) gas...

  • Review
  • Open Access
4 Citations
4,091 Views
37 Pages

Field-effect transistor (FET) chemical sensors are essential for enabling sophisticated lifestyles and ensuring safe working environments. They can detect a wide range of analytes, including gaseous species (NO2, NH3, VOCs), ionic compounds, and biol...

  • Article
  • Open Access
1 Citations
1,961 Views
11 Pages

Ultraflexible Chemiresistive NO2 Gas Sensor Realized with Photopatterned Porous Polymer Film

  • Xingda Yi,
  • Banghua Wu,
  • Lin Gao,
  • Yujie Peng,
  • Yong Huang and
  • Junsheng Yu

The development of ultraflexible and sensitive gas sensors is critical for advancing next-generation environmental monitoring and healthcare diagnostics. In this work, we demonstrate an ultraflexible chemiresistive nitrogen dioxide (NO2) sensor integ...

  • Perspective
  • Open Access
1 Citations
3,980 Views
29 Pages

Although traditional drug delivery methods are widely used in clinical practice, their inherent limitations often compromise therapeutic efficacy. Therefore, the development of more precise and efficient drug delivery systems is essential to enhance...

  • Article
  • Open Access
1,261 Views
16 Pages

The electrochemical polymerization of guaiacol was studied in different organic solvents. Significant electrode blocking was observed in dichloromethane. Microscopic studies verified the formation of a coherent deposit on the platinum electrode. In a...

  • Communication
  • Open Access
2 Citations
2,088 Views
11 Pages

Analysis of Ergothioneine Using Surface-Enhanced Raman Scattering: Detection in Mushrooms

  • Federico Puliga,
  • Veronica Zuffi,
  • Alessandra Zambonelli,
  • Pavol Miškovský,
  • Ornella Francioso and
  • Santiago Sanchez-Cortes

Surface-enhanced Raman scattering (SERS) spectroscopy is a straightforward analytical technique capable of providing detailed information about metabolites in biological samples. The objective of this study was to perform a SERS analysis of ergothion...

  • Article
  • Open Access
1,669 Views
14 Pages

Green On-Site Diclofenac Extraction from Wastewater Matrices Using a 3D-Printed Device Followed by PTV-GC-MS Determination

  • César Castro-García,
  • Edwin Palacio,
  • Rogelio Rodríguez-Maese,
  • Luz O. Leal and
  • Laura Ferrer

A 3D-printed device was designed and printed by a stereolithographic technique (SLA) and coated with a highly selective solid phase extraction resin for on-site diclofenac extraction from wastewater, avoiding the transport and treatment of large volu...

  • Communication
  • Open Access
3,571 Views
10 Pages

This study presents a microbial sensing device that employs a poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) matrix to immobilize viable and metabolically Escherichia coli cells. This device enables the monitoring of microorganism...

  • Article
  • Open Access
1,900 Views
19 Pages

Simultaneous molecular recognition and quantification of at least four biomarkers in biological samples may contribute to early and fast diagnosis of illnesses such as cancer. The electrodes able to reliably perform on-site these tests are the stocha...

  • Review
  • Open Access
5 Citations
3,960 Views
30 Pages

The development of functional biosensors is rapidly advancing in response to the growing demand for personalized and continuous healthcare monitoring. Two-dimensional (2D) nanostructured materials have attracted significant attention for next-generat...

  • Article
  • Open Access
1 Citations
1,587 Views
14 Pages

Sensitive Gold Nanostar-Based Adsorption Sensor for the Determination of Dexamethasone

  • Riccarda Thelma MacDonald,
  • Keagan Pokpas,
  • Emmanuel Iwuoha and
  • Candice Cupido

Herein, a novel, highly efficient electrochemical adsorption method is introduced for detection of the potent anti-inflammatory synthetic corticosteroid, dexamethasone (DEX). Unlike conventional electrochemical techniques that rely on high reduction...

  • Article
  • Open Access
1 Citations
1,341 Views
16 Pages

Air-Assisted Liquid–Liquid Microextraction (AALLME) as an Alternative Sample Pre-Treatment for Isolating Tetrahydrocannabinol (THC) from Hair

  • Laura Blanco-García,
  • Pamela Cabarcos-Fernández,
  • Iván Álvarez-Freire,
  • María Jesús Tabernero-Duque,
  • Antonio Moreda-Piñeiro and
  • Ana María Bermejo-Barrera

Cannabis remains the most widely used illicit drug worldwide, identifying it is a routine procedure in forensic toxicology. Due to its widespread use, there is a need for analytical methods that can detect it in biological samples. Hair is of particu...

  • Article
  • Open Access
2 Citations
2,399 Views
15 Pages

Glutamine is an essential biomolecule that plays a pivotal role in many diseases, such as cancer, where it can serve as fuel for rapid proliferation. Treatments for these diseases can be monitored and optimized through the detection of glutamine, tho...

  • Review
  • Open Access
2 Citations
4,748 Views
25 Pages

Drink spiking is a significant public safety issue, often linked to crimes such as theft and sexual assault. The detection of drugs used in these incidents is challenging due to the low concentrations (<ng) and complex matrices involved. This revi...

  • Review
  • Open Access
4,329 Views
36 Pages

This review aims to summarize possible methods for the detection of limonene in the gas phase at low to very low concentrations. Limonene has historically been of interest as a fragrance in cosmetics, the food industry, pharmaceutics, and the product...

  • Article
  • Open Access
1,552 Views
18 Pages

Tea contains bioactive components that provide many health benefits, but overdoses can also cause health problems related to fluorosis, among other things. The analysis of tea quality is complicated due to its diverse chemical composition, and also d...

  • Article
  • Open Access
2,574 Views
27 Pages

The colour degradation of murals presents a significant challenge in the conservation of architectural heritage. Previous research has often concentrated on localized pigment changes while paying insufficient attention to the interaction between colo...

  • Article
  • Open Access
5 Citations
2,118 Views
16 Pages

The growing global burden of diabetes necessitates the development of glucose sensors that are not only reliable and sensitive but also cost-effective and amenable to point-of-care use. In this work, we report a non-enzymatic electrochemical glucose...

  • Article
  • Open Access
2 Citations
1,825 Views
12 Pages

Hydroxychloroquine (HCQ), a cornerstone therapeutic agent for autoimmune diseases, requires precise serum concentration monitoring due to its narrow therapeutic window. Current HCQ monitoring methods such as HPLC and LC-MS/MS are sensitive but costly...

  • Article
  • Open Access
2 Citations
1,214 Views
11 Pages

Alzheimer’s disease (AD) affects a significant portion of humanity’s elderly population across the globe. Recent studies have identified Amyloid-Beta 42 (Aβ42) as a key biomarker for AD. In this research, we examined the feasibility...

  • Article
  • Open Access
1,828 Views
15 Pages

Compact Dual-Wavelength Optical Fiber Sensor for the Simultaneous Measurement of the Refractive Index and Temperature of Liquid Samples

  • Karla Ivonne Serrano-Arévalo,
  • Erika Rodríguez-Sevilla,
  • Monserrat Alonso-Murias,
  • Héctor Pérez-Aguilar and
  • David Monzón-Hernández

This study proposes the development of a dual-wavelength optical fiber sensor (DWOFS) that integrates two optical fiber structures in a multimode transmission line to measure the refractive index and temperature of a liquid concurrently. One structur...

  • Article
  • Open Access
1 Citations
1,285 Views
14 Pages

Carbon and Nitrogen Surface Contamination Contributions in ZnO Nanowire Based Hydrogen Sensing

  • Aurelian Marcu,
  • Sorin Vizireanu,
  • Razvan Mihalcea,
  • Veronica Satulu,
  • Maria Balan,
  • Marius Dumitru,
  • Valentin Craciun,
  • Catalin Constantin and
  • Cristian Viespe

Hexagonal ZnO nanowires were grown using the PLD/VLS technique on a SAW sensor active area for hydrogen sensing. The influence of different carbon and nitrogen surface contaminant concentrations on sensor output was investigated for three active area...

  • Article
  • Open Access
1 Citations
1,392 Views
12 Pages

For authentication and interpretation of palm-leaf manuscripts, material analyses are required that enable identification of specific characteristics of written artefacts. In this study, we apply infrared spectroscopy (DRIFTS) in combination with pri...

  • Article
  • Open Access
1,462 Views
16 Pages

Sensitive Hydrogen Peroxide Sensor Based on Hexacyanoferrate Nickel–Carbon Nanodots

  • Emiliano Martínez-Periñán,
  • Juan Manuel Hernández-Gómez,
  • Encarnación Lorenzo and
  • Cristina Gutiérrez-Sánchez

An electrochemical sensor was developed for the detection of hydrogen peroxide (H2O2) based on the in situ formation of a nickel hexacyanoferrate complex on the electrode surface. Screen-printed carbon electrodes were modified with nickel-doped carbo...

  • Article
  • Open Access
1,183 Views
15 Pages

Titanium dioxide (TiO2) is one of the most widely produced nanomaterials. Many products contain nanoparticles because they have various technological, medical, and economic benefits. However, the presence of nanoparticles in the environment has a neg...

  • Article
  • Open Access
1 Citations
1,260 Views
14 Pages

Novel Solid-Phase Bioassay Kit with Immobilized Chlorella vulgaris Spheres for Assessing Heavy Metal and Cyanide Toxicity in Soil

  • Fida Hussain,
  • Suleman Shahzad,
  • Syed Ejaz Hussain Mehdi,
  • Aparna Sharma,
  • Sandesh Pandey,
  • Woochang Kang and
  • Sang-Eun Oh

Heavy metal and cyanide contamination in soil presents serious environmental and ecological concerns due to their persistence, bioavailability, and toxicity to soil biota. In this study, a novel solid-phase direct contact bioassay kit was developed u...

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Chemosensors - ISSN 2227-9040