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Proteomes, Volume 5, Issue 2

June 2017 - 3 articles

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Articles (3)

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Article

14 Citations

7,072 Views

16 Pages

A Routine ‘Top-Down’ Approach to Analysis of the Human Serum Proteome

Arlene M. D’Silva,
Jon A. Hyett and
Jens R. Coorssen

Proteomes2017, 5(2), 13;https://doi.org/10.3390/proteomes5020013

6 June 2017

Serum provides a rich source of potential biomarker proteoforms. One of the major obstacles in analysing serum proteomes is detecting lower abundance proteins owing to the presence of hyper-abundant species (e.g., serum albumin and immunoglobulins)....

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Review

40 Citations

10,557 Views

31 Pages

A Comprehensive Guide for Performing Sample Preparation and Top-Down Protein Analysis

Matthew P. Padula,
Iain J. Berry,
Matthew B. O′Rourke,
Benjamin B.A. Raymond,
Jerran Santos and
Steven P. Djordjevic

Proteomes2017, 5(2), 11;https://doi.org/10.3390/proteomes5020011

7 April 2017

Methodologies for the global analysis of proteins in a sample, or proteome analysis, have been available since 1975 when Patrick O′Farrell published the first paper describing two-dimensional gel electrophoresis (2D-PAGE). This technique allowed the...

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Editorial

4 Citations

4,830 Views

3 Pages

Clinical Proteomics: From Biological Sample to Clinical Exploitation

Edwin Lasonder

Proteomes2017, 5(2), 10;https://doi.org/10.3390/proteomes5020010

6 April 2017

Technological advances in mass spectrometry instrumentation and proteomics methodologies are moving the field of clinical proteomics towards the analysis of large numbers of patient samples in a reasonable time. The Special Issue ‘Clinical proteomics...

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