- Brief Report
Timing of Naldemedine Initiation and Occurrence of Diarrhea in Patients Receiving Strong Opioid Analgesics: A Retrospective Study
- Takuma Matsumoto,
- Takuya Mura,
- Tsubasa Wada,
- Yuki Tsugo,
- Naoko Mukai,
- Terutaka Hamaoka,
- Shuji Horita,
- Yasushi Semba and
- Shinichi Watanabe
Naldemedine, a peripherally acting μ-opioid receptor antagonist, is used to treat opioid-induced constipation (OIC). However, it causes diarrhea as an adverse effect. This retrospective study aimed to investigate whether the occurrence of diarrhea...

