Biomolecules, Volume 16, Issue 6
2026 June - 168 articles
Cover Story: Gelatin can be functionalized with methacryloyl, phenolic, or norbornene groups to form crosslinkable derivatives such as GelMA, GelPH, and GelNB for tissue engineering applications. While these materials are commonly evaluated after hydrogel formation, cells may also encounter soluble precursors during preparation and residual functional groups after gelation. The biological influence of such uncrosslinked gelatin derivatives remains insufficiently understood. In this study, we compare GelMA, GelPH, and GelNB under matched degrees of functionalization and concentrations, revealing that functional group chemistry can shape distinct, cell-dependent responses. The cover illustrates how varying gelatin chemistries may communicate differently with cells before or beyond hydrogel formation. View this paper
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Biomolecules - ISSN 2218-273X