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Biomolecules, Volume 15, Issue 2
2025 February - 159 articles
Cover Story: Unlocking Cancer’s Secrets: Novel Ubiquitin-Specific Protease (USP) inhibitors show promise for targeted cancer therapy by disrupting key cellular processes. The attached image illustrates a conceptual representation of how novel USP inhibitors work as targeted therapies for cancer. The visual metaphor of a “lock and key” mechanism symbolizes the interaction between these inhibitors and specific cellular processes critical for cancer progression. A magnified section in the image shows a chemical interaction involving cysteine (Cys) and histidine (His), which are critical residues in the catalytic site of USPs. The development of these novel inhibitors offers hope for personalized treatments by targeting specific molecular pathways that are dysregulated in individual cancers. View this paper
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Biomolecules - ISSN 2218-273X