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Biomolecules, Volume 12, Issue 11

2022 November - 180 articles

Cover Story: Six purine lesions were ascertained in the mtDNA of wild type CSA and CSB cells and defective counterparts in comparison with the corresponding total (t) DNA (t = n + mt). The two 8–oxo–purine (8–oxo–Pu) levels were found to be in the range of 25–50 lesions/107 nucleotides in both genetic materials. The four 5′,8–cyclopurine (cPu) were undetectable in the mtDNA both in defective cells and in the wt counterparts (CSA and CSB), indicating a nonappearance of hydroxyl radical (HO•) reactivity within the mtDNA. Via parallel γ–radiolysis experiments on isolated genetic materials from wtCSB cells, a higher resistance to HO• attack was demonstrated in the case of mtDNA compared with nDNA, likely due to their different DNA helical topology influencing the relative abundance of the lesions. View this paper
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