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Biomolecules, Volume 11, Issue 9

2021 September - 139 articles

Cover Story: Decreased Cerebrospinal Fluid Antioxidative Capacity Is Related to Disease Severity and Progression in Early Multiple Sclerosis Oxidative stress-induced neuronal damage in multiple sclerosis (MS) results from an imbalance between toxic free radicals and counteracting antioxidants, i.e., antioxidative capacity (AOC). We determined the AOC of cerebrospinal fluid (CSF) and serum of MS patients and controls as the sample’s ability to inhibit 2,2′-azobis(2-amidinopropane) dihydrochloride-induced oxidation of dihydrorhodamine. We found that CSF AOC was associated with increased disability and clinical disease activity in MS. View this paper.
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