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Biomolecules, Volume 11, Issue 10
October 2021 - 154 articles
Cover Story: The overexpression of telomerase in 90% of human cancers justifies the design of anticancer drugs having this enzyme as the potential target. In this context, telomerase inhibition by G-Quadruplexes (GQ) stabilizing ligands is considered a useful approach. Derivatives such as 5,10,15,20-tetrakis(N-methyl-4-pyridinium)porphyrin (H2TMPyP) are recognized to have promising features to be exploited as GQ lignds. Herein, after an insight on the structural diversity and recognition modes of GQ, studies of H2TMPyP and analogs, namely, metallocomplexes with GQ and duplex DNA sequences, were analyzed. The review was complemented with a screening where the behavior of H2TMPyP and of some metal complexes was evaluated under the same experimental conditions and using the same DNA sequences. An interesting pattern of selectivity was identified for the AgIITMPyP complex.View this paper
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Biomolecules - ISSN 2218-273X