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Biomolecules, Volume 10, Issue 9

2020 September - 153 articles

Cover Story: Human transcription factors regulate the expression of target genes through their transactivation domains (TADs). As a first step, TADs interact with coactivators that are part of the general transcriptional machinery. MED25, a subunit of the mediator complex, is a coactivator that binds TADs through a cleft on its surface. Since most TADs adopt a rod-like, -helical structure, it is likely that TADs bind only in two main orientations (‘cis’ and ‘trans’) and cannot readily switch between these once bound. TADs, therefore, need to be able to bind bidirectionally. Here, Jeffery and Weinzierl show through computational simulations that human (ETV5) and viral (VP16) TADs can bind in both directions by employing alternative sets of residues to stabilize binding to the coactivator surface. View this paper
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Biomolecules - ISSN 2218-273X
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