Table of Contents
Biomolecules, Volume 8, Issue 2 (June 2018)
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Cover Story (view full-size image) The rapamycin-sensitive TOR kinase, an essential regulator of cell growth, assembles into two [...] Read more. The rapamycin-sensitive TOR kinase, an essential regulator of cell growth, assembles into two multi-protein complexes, termed TORC1 and TORC2. Taking advantage of two homologous TOR kinases in budding yeast, a minimal assembly specificity (MAS) domain was identified that governs their assembly into TORC1 versus TORC2. Based on a recent structural study of TORC2 by Loewith and colleagues, the TORC2 MAS domain (depicted in blue) is predicted to be involved in quaternary interactions (shown in yellow, green, and red) important for TORC2 specificity and assembly. View Paper here.