Special Issue "Calcium Binding Proteins: Structure, Properties, Functions"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (30 June 2018).
Interests: protein physics; luminescence (fluorescence, phosphorescence) spectroscopy of proteins; scanning and titration calorimetry of proteins; metal binding proteins; calcium binding proteins
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Interests: intrinsically disordered proteins; protein folding; protein misfolding; partially folded proteins; protein aggregation; protein structure; protein function; protein stability; protein biophysics; protein bioinformatics; conformational diseases; protein–ligand interactions; protein–protein interactions; liquid-liquid phase transitions
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Calcium regulates all important aspects of cell activity, beginning with fertilization and ending with the apoptotic suicide at the end of the life cycle. Calcium binding proteins play important roles in practically all biological processes. Now we know several large families of calcium binding proteins and three-dimensional structures of their main representatives are well known. Nevertheless, each year brings us many new structures. Analysis of these structures allows revealing general principles of their design, which can be used in protein engineering. Most calcium binding proteins play regulatory roles activating or deactivating various biological systems. Calcium-binding proteins of cytosol and membrane calcium-binding proteins directed to cytosol are called calcium modulated proteins as they take part in generation of calcium gradient across cells and/or transfer external impulse information. At the same time, there exist calcium binding proteins, which modulate calcium flows inside cells. In spite of the knowledge of three-dimensional structures of many calcium binding proteins, the exact physiological function of many of them is still unknown or known only hypothetically.
It is useful from time to time to collect our new knowledge on calcium binding proteins in several good reviews to draw some generalizations for further success of our future academic studies and applied developments. This is the main goal of the present Special Issue of Biomolecules.
Prof. Dr. Eugene Permyakov
Dr. Vladimir N. Uversky
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- calcium binding proteins
- metal binding proteins