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Metabolites, Volume 9, Issue 6

2019 June - 17 articles

Cover Story: Phosphatidylcholines (PC) are major constituents of eukaryotic cell membranes and represent important components of lipoproteins. Modern lipidomics approaches allow quantification of these lipids at different structural resolutions in blood from large human cohorts. Bulk PC measures, representing sums of isobaric PCs with different lipid side-chain compositions were shown to associate with various diseases and genetic variation. However, functional interpretation of these associations is limited without knowing their compositions in terms of fatty acid lengths and desaturation. In this paper, we characterized the constituents of PC sums by comparison with side-chain resolving measures for the same samples. In addition to identifying the major constituents of PC sums, our work highlighted relatively high abundance of less expected compositions, such as a high proportion of PCs with C22:6 and odd-numbered fatty acid chains. View this paper

Articles (17)

  • Article
  • Open Access
18 Citations
4,836 Views
19 Pages

Metabolomic Variability of Different Genotypes of Cashew by LC-Ms and Correlation with Near-Infrared Spectroscopy as a Tool for Fast Phenotyping

  • Elenilson Alves Filho,
  • Lorena Mara Silva,
  • Ynayara Lima,
  • Paulo Ribeiro,
  • Ebenézer Silva,
  • Guilherme Zocolo,
  • Kirley Canuto,
  • Selene Morais,
  • Ana Cecília Castro and
  • Edy de Brito

The objective of the present work was to develop an advanced fast phenotyping tool to explore the cashew apple compositions from different genotypes, based on a portable near-infrared (MicroNIR) spectroscopy. This will be in addition to associating t...

  • Article
  • Open Access
47 Citations
9,211 Views
15 Pages

Mass Spectrometry Data Repository Enhances Novel Metabolite Discoveries with Advances in Computational Metabolomics

  • Hiroshi Tsugawa,
  • Aya Satoh,
  • Haruki Uchino,
  • Tomas Cajka,
  • Makoto Arita and
  • Masanori Arita

Mass spectrometry raw data repositories, including Metabolomics Workbench and MetaboLights, have contributed to increased transparency in metabolomics studies and the discovery of novel insights in biology by reanalysis with updated computational met...

  • Article
  • Open Access
18 Citations
4,645 Views
21 Pages

Identifying Metabolomic Profiles of Insulinemic Dietary Patterns

  • Fred K. Tabung,
  • Raji Balasubramanian,
  • Liming Liang,
  • Steven K. Clinton,
  • Elizabeth M. Cespedes Feliciano,
  • JoAnn E. Manson,
  • Linda Van Horn,
  • Jean Wactawski-Wende,
  • Clary B. Clish and
  • Kathryn M. Rexrode
  • + 1 author

The food-based empirical dietary index for hyperinsulinemia (EDIH) score assesses the insulinemic potential of diet. This cross-sectional study evaluated associations between EDIH scores from food frequency questionnaires with c-peptide concentration...

  • Article
  • Open Access
12 Citations
6,461 Views
14 Pages

A Quantitative HILIC–MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

  • Qing Liu,
  • Jingwei Cai,
  • Robert G. Nichols,
  • Yuan Tian,
  • Jintao Zhang,
  • Philip B. Smith,
  • Yan Wang,
  • Chao Yan and
  • Andrew D. Patterson

A hydrophilic interaction liquid chromatography (HILIC)–ultra high-pressure liquid chromatography (UHPLC) coupled with tandem mass spectrometry (MS/MS) method was developed and applied to profile metabolite changes in human Huh-7 cells exposed...

  • Review
  • Open Access
63 Citations
9,656 Views
27 Pages

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective

  • Su H. Chu,
  • Mengna Huang,
  • Rachel S. Kelly,
  • Elisa Benedetti,
  • Jalal K. Siddiqui,
  • Oana A. Zeleznik,
  • Alexandre Pereira,
  • David Herrington,
  • Craig E. Wheelock and
  • on behalf of the Consortium of Metabolomics Studies Statistics Working Group
  • + 6 authors

It is not controversial that study design considerations and challenges must be addressed when investigating the linkage between single omic measurements and human phenotypes. It follows that such considerations are just as critical, if not more so,...

  • Article
  • Open Access
20 Citations
4,674 Views
17 Pages

Comparison of the Serum Metabolic Fingerprint of Different Exercise Modes in Men with and without Metabolic Syndrome

  • Aikaterina Siopi,
  • Olga Deda,
  • Vasiliki Manou,
  • Ioannis Kosmidis,
  • Despina Komninou,
  • Nikolaos Raikos,
  • Georgios A. Theodoridis and
  • Vassilis Mougios

Exercise plays a beneficial role in the treatment of metabolic syndrome (MetS). Metabolomics can provide new insights and facilitate the optimization of exercise prescription. This study aimed to investigate whether the response of the human serum me...

  • Article
  • Open Access
31 Citations
8,024 Views
24 Pages

Euglena Central Metabolic Pathways and Their Subcellular Locations

  • Sahutchai Inwongwan,
  • Nicholas J. Kruger,
  • R. George Ratcliffe and
  • Ellis C. O’Neill

Euglenids are a group of algae of great interest for biotechnology, with a large and complex metabolic capability. To study the metabolic network, it is necessary to know where the component enzymes are in the cell, but despite a long history of rese...

  • Article
  • Open Access
13 Citations
4,880 Views
19 Pages

Comparative Metabolomics of Early Development of the Parasitic Plants Phelipanche aegyptiaca and Triphysaria versicolor

  • Kristen Clermont,
  • Yaxin Wang,
  • Siming Liu,
  • Zhenzhen Yang,
  • Claude W. dePamphilis,
  • John I. Yoder,
  • Eva Collakova and
  • James H. Westwood

Parasitic weeds of the family Orobanchaceae attach to the roots of host plants via haustoria capable of drawing nutrients from host vascular tissue. The connection of the haustorium to the host marks a shift in parasite metabolism from autotrophy to...

  • Article
  • Open Access
67 Citations
11,193 Views
21 Pages

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

  • Stefano Patassini,
  • Paul Begley,
  • Jingshu Xu,
  • Stephanie J. Church,
  • Nina Kureishy,
  • Suzanne J. Reid,
  • Henry J. Waldvogel,
  • Richard L. M. Faull,
  • Russell G. Snell and
  • Garth J. S. Cooper
  • + 1 author

Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of t...

  • Review
  • Open Access
45 Citations
7,173 Views
19 Pages

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease

  • Nan Ran,
  • Zhiqiang Pang,
  • Yinuo Gu,
  • He Pan,
  • Xu Zuo,
  • Xuewa Guan,
  • Yuze Yuan,
  • Ziyan Wang,
  • Yingqiao Guo and
  • Fang Wang
  • + 1 author

Chronic obstructive pulmonary disease (COPD), a common and heterogeneous respiratory disease, is characterized by persistent and incompletely reversible airflow limitation. Metabolomics is applied to analyze the difference of metabolic profile based...

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Metabolites - ISSN 2218-1989