Table of Contents
Metabolites, Volume 9, Issue 6 (June 2019)
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Cover Story (view full-size image) Phosphatidylcholines (PC) are major constituents of eukaryotic cell membranes and represent [...] Read more. Phosphatidylcholines (PC) are major constituents of eukaryotic cell membranes and represent important components of lipoproteins. Modern lipidomics approaches allow quantification of these lipids at different structural resolutions in blood from large human cohorts. Bulk PC measures, representing sums of isobaric PCs with different lipid side-chain compositions were shown to associate with various diseases and genetic variation. However, functional interpretation of these associations is limited without knowing their compositions in terms of fatty acid lengths and desaturation. In this paper, we characterized the constituents of PC sums by comparison with side-chain resolving measures for the same samples. In addition to identifying the major constituents of PC sums, our work highlighted relatively high abundance of less expected compositions, such as a high proportion of PCs with C22:6 and odd-numbered fatty acid chains. View this paper