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Metabolites, Volume 9, Issue 6

2019 June - 17 articles

Cover Story: Phosphatidylcholines (PC) are major constituents of eukaryotic cell membranes and represent important components of lipoproteins. Modern lipidomics approaches allow quantification of these lipids at different structural resolutions in blood from large human cohorts. Bulk PC measures, representing sums of isobaric PCs with different lipid side-chain compositions were shown to associate with various diseases and genetic variation. However, functional interpretation of these associations is limited without knowing their compositions in terms of fatty acid lengths and desaturation. In this paper, we characterized the constituents of PC sums by comparison with side-chain resolving measures for the same samples. In addition to identifying the major constituents of PC sums, our work highlighted relatively high abundance of less expected compositions, such as a high proportion of PCs with C22:6 and odd-numbered fatty acid chains. View this paper

Articles (17)

  • Article
  • Open Access
20 Citations
5,104 Views
19 Pages

Metabolomic Variability of Different Genotypes of Cashew by LC-Ms and Correlation with Near-Infrared Spectroscopy as a Tool for Fast Phenotyping

  • Elenilson Alves Filho,
  • Lorena Mara Silva,
  • Ynayara Lima,
  • Paulo Ribeiro,
  • Ebenézer Silva,
  • Guilherme Zocolo,
  • Kirley Canuto,
  • Selene Morais,
  • Ana Cecília Castro and
  • Edy de Brito

The objective of the present work was to develop an advanced fast phenotyping tool to explore the cashew apple compositions from different genotypes, based on a portable near-infrared (MicroNIR) spectroscopy. This will be in addition to associating t...

(This article belongs to the Special Issue Fruit Metabolism and Metabolomics)
  • Article
  • Open Access
49 Citations
9,742 Views
15 Pages

Mass Spectrometry Data Repository Enhances Novel Metabolite Discoveries with Advances in Computational Metabolomics

  • Hiroshi Tsugawa,
  • Aya Satoh,
  • Haruki Uchino,
  • Tomas Cajka,
  • Makoto Arita and
  • Masanori Arita

Mass spectrometry raw data repositories, including Metabolomics Workbench and MetaboLights, have contributed to increased transparency in metabolomics studies and the discovery of novel insights in biology by reanalysis with updated computational met...

(This article belongs to the Special Issue Metabolomics Data Processing and Data Analysis—Current Best Practices)
  • Article
  • Open Access
18 Citations
5,017 Views
21 Pages

Identifying Metabolomic Profiles of Insulinemic Dietary Patterns

  • Fred K. Tabung,
  • Raji Balasubramanian,
  • Liming Liang,
  • Steven K. Clinton,
  • Elizabeth M. Cespedes Feliciano,
  • JoAnn E. Manson,
  • Linda Van Horn,
  • Jean Wactawski-Wende,
  • Clary B. Clish and
  • Kathryn M. Rexrode
  • + 1 author

The food-based empirical dietary index for hyperinsulinemia (EDIH) score assesses the insulinemic potential of diet. This cross-sectional study evaluated associations between EDIH scores from food frequency questionnaires with c-peptide concentration...

(This article belongs to the Special Issue Metabolomics in Epidemiological Studies)
  • Article
  • Open Access
14 Citations
6,815 Views
14 Pages

A Quantitative HILIC–MS/MS Assay of the Metabolic Response of Huh-7 Cells Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

  • Qing Liu,
  • Jingwei Cai,
  • Robert G. Nichols,
  • Yuan Tian,
  • Jintao Zhang,
  • Philip B. Smith,
  • Yan Wang,
  • Chao Yan and
  • Andrew D. Patterson

A hydrophilic interaction liquid chromatography (HILIC)–ultra high-pressure liquid chromatography (UHPLC) coupled with tandem mass spectrometry (MS/MS) method was developed and applied to profile metabolite changes in human Huh-7 cells exposed...

  • Review
  • Open Access
70 Citations
10,195 Views
27 Pages

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective

  • Su H. Chu,
  • Mengna Huang,
  • Rachel S. Kelly,
  • Elisa Benedetti,
  • Jalal K. Siddiqui,
  • Oana A. Zeleznik,
  • Alexandre Pereira,
  • David Herrington,
  • Craig E. Wheelock and
  • on behalf of the Consortium of Metabolomics Studies Statistics Working Group
  • + 6 authors

It is not controversial that study design considerations and challenges must be addressed when investigating the linkage between single omic measurements and human phenotypes. It follows that such considerations are just as critical, if not more so,...

(This article belongs to the Special Issue Metabolomics in Epidemiological Studies)
  • Article
  • Open Access
21 Citations
5,097 Views
17 Pages

Comparison of the Serum Metabolic Fingerprint of Different Exercise Modes in Men with and without Metabolic Syndrome

  • Aikaterina Siopi,
  • Olga Deda,
  • Vasiliki Manou,
  • Ioannis Kosmidis,
  • Despina Komninou,
  • Nikolaos Raikos,
  • Georgios A. Theodoridis and
  • Vassilis Mougios

Exercise plays a beneficial role in the treatment of metabolic syndrome (MetS). Metabolomics can provide new insights and facilitate the optimization of exercise prescription. This study aimed to investigate whether the response of the human serum me...

(This article belongs to the Special Issue Exercise Metabonomics)
  • Article
  • Open Access
34 Citations
9,388 Views
24 Pages

Euglena Central Metabolic Pathways and Their Subcellular Locations

  • Sahutchai Inwongwan,
  • Nicholas J. Kruger,
  • R. George Ratcliffe and
  • Ellis C. O’Neill

Euglenids are a group of algae of great interest for biotechnology, with a large and complex metabolic capability. To study the metabolic network, it is necessary to know where the component enzymes are in the cell, but despite a long history of rese...

(This article belongs to the Special Issue Metabolites from Phototrophic Prokaryotes and Algae Volume 2)
  • Article
  • Open Access
14 Citations
5,171 Views
19 Pages

Comparative Metabolomics of Early Development of the Parasitic Plants Phelipanche aegyptiaca and Triphysaria versicolor

  • Kristen Clermont,
  • Yaxin Wang,
  • Siming Liu,
  • Zhenzhen Yang,
  • Claude W. dePamphilis,
  • John I. Yoder,
  • Eva Collakova and
  • James H. Westwood

Parasitic weeds of the family Orobanchaceae attach to the roots of host plants via haustoria capable of drawing nutrients from host vascular tissue. The connection of the haustorium to the host marks a shift in parasite metabolism from autotrophy to...

(This article belongs to the Special Issue Metabolomics in Agriculture)
  • Article
  • Open Access
73 Citations
12,991 Views
21 Pages

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

  • Stefano Patassini,
  • Paul Begley,
  • Jingshu Xu,
  • Stephanie J. Church,
  • Nina Kureishy,
  • Suzanne J. Reid,
  • Henry J. Waldvogel,
  • Richard L. M. Faull,
  • Russell G. Snell and
  • Garth J. S. Cooper
  • + 1 author

Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of t...

  • Review
  • Open Access
50 Citations
7,682 Views
19 Pages

An Updated Overview of Metabolomic Profile Changes in Chronic Obstructive Pulmonary Disease

  • Nan Ran,
  • Zhiqiang Pang,
  • Yinuo Gu,
  • He Pan,
  • Xu Zuo,
  • Xuewa Guan,
  • Yuze Yuan,
  • Ziyan Wang,
  • Yingqiao Guo and
  • Fang Wang
  • + 1 author

Chronic obstructive pulmonary disease (COPD), a common and heterogeneous respiratory disease, is characterized by persistent and incompletely reversible airflow limitation. Metabolomics is applied to analyze the difference of metabolic profile based...

(This article belongs to the Special Issue Metabolomics and Chronic Obstructive Lung Diseases)
  • Article
  • Open Access
27 Citations
5,105 Views
13 Pages

Dynamic Changes of Plasma Metabolome in Response to Severe Feed Restriction in Pregnant Ewes

  • Changzheng Guo,
  • Yanfeng Xue,
  • Hossam-eldin Seddik,
  • Yuyang Yin,
  • Fan Hu and
  • Shengyong Mao

Maternal metabolic disorders in ewes induced by energy deficiency have a detrimental effect on the maternal health and lambs. However, the dynamic processes of metabolic disorders are unknown. Therefore, this study attempted to explore the dynamic ch...

  • Article
  • Open Access
10 Citations
4,335 Views
8 Pages

Secondary Metabolites of Aeromonas veronii Strain A134 Isolated from a Microcystis aeruginosa Bloom

  • Gad Weiss,
  • Dimitry Kovalerchick,
  • Omer Murik,
  • Assaf Sukenik,
  • Aaron Kaplan and
  • Shmuel Carmeli

Aeromonas veronii strain A134 was isolated from Microcystis aeruginosa colonies collected from Lake Kinneret (Sea of Galilee), Israel. The Aeromonas culture media inhibited the growth of M. aeruginosa (strain MGK). The crude extract of a large-scale...

(This article belongs to the Special Issue Metabolomics in Chemical Ecology)
  • Article
  • Open Access
27 Citations
7,793 Views
18 Pages

Characterization of Bulk Phosphatidylcholine Compositions in Human Plasma Using Side-Chain Resolving Lipidomics

  • Jan D. Quell,
  • Werner Römisch-Margl,
  • Mark Haid,
  • Jan Krumsiek,
  • Thomas Skurk,
  • Anna Halama,
  • Nisha Stephan,
  • Jerzy Adamski,
  • Hans Hauner and
  • Gabi Kastenmüller
  • + 4 authors

Kit-based assays, such as AbsoluteIDQTM p150, are widely used in large cohort studies and provide a standardized method to quantify blood concentrations of phosphatidylcholines (PCs). Many disease-relevant associations of PCs were reported using this...

(This article belongs to the Special Issue Metabolomics in Epidemiological Studies)
  • Conference Report
  • Open Access
22 Citations
6,804 Views
11 Pages

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium

  • Pei Zhang,
  • Manish Arora,
  • Romanas Chaleckis,
  • Tomohiko Isobe,
  • Mohit Jain,
  • Isabel Meister,
  • Erik Melén,
  • Matthew Perzanowski,
  • Federico Torta and
  • Craig E. Wheelock
  • + 1 author

The attempt to describe complex diseases by solely genetic determination has not been successful. There is increasing recognition that the development of disease is often a consequence of interactions between multiple genetic and environmental factor...

  • Article
  • Open Access
10 Citations
6,293 Views
12 Pages

We succeeded in simultaneously synthesizing the vitamin D family, vitamins D2, D4, D5, D6, and D7, from β-sitosterol, which is sold as a commercially available reagent from Tokyo Chemical Industry Co., Ltd. It is officially sold as a mixture of...

(This article belongs to the Special Issue Compound Identification of Small Molecules)
  • Perspective
  • Open Access
207 Citations
13,068 Views
25 Pages

Translational Metabolomics: Current Challenges and Future Opportunities

  • Farhana R. Pinu,
  • Seyed Ali Goldansaz and
  • Jacob Jaine

Metabolomics is one of the latest omics technologies that has been applied successfully in many areas of life sciences. Despite being relatively new, a plethora of publications over the years have exploited the opportunities provided through this dat...

(This article belongs to the Section Food Metabolomics)
  • Article
  • Open Access
12 Citations
4,895 Views
13 Pages

Exo-Metabolites of Phaseolus vulgaris-Nodulating Rhizobial Strains

  • Diana Montes-Grajales,
  • Nuria Esturau-Escofet,
  • Baldomero Esquivel and
  • Esperanza Martinez-Romero

Rhizobia are able to convert dinitrogen into biologically available forms of nitrogen through their symbiotic association with leguminous plants. This results in plant growth promotion, and also in conferring host resistance to different types of str...

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Metabolites - ISSN 2218-1989