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Metabolites, Volume 12, Issue 8

August 2022 - 101 articles

Cover Story: The effect of COVID-19 infection on the human metabolome has been widely reported, but to date, all such studies have focused on a single wave of infection. This work used a targeted metabolomics platform (Biocrates Life Sciences) to analyze samples across two waves of infection. This work demonstrates, for the first time, that metabolic dysregulation has partially changed over the course of the pandemic, reflecting changes in variants, clinical presentation, and treatment regimes. It also shows that some metabolic changes are robust across waves, and these can differentiate COVID-19-positive individuals from controls in a hospital setting. This research also supports the hypothesis that some metabolic pathways are disrupted several months after COVID-19 infection. View this paper
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Articles (101)

  • Article
  • Open Access
34 Citations
5,492 Views
13 Pages

19 August 2022

The rhizosphere microbiome is a major determinant of plant health. Plant-beneficial or plant growth-promoting rhizobacteria (PGPR) influence plant growth, plant development and adaptive responses, such as induced resistance/priming. These new eco-fri...

  • Article
  • Open Access
3 Citations
2,539 Views
13 Pages

18 August 2022

Probiotics are live microorganisms distributed in the gastrointestinal tract that confer health benefits to the host when administered in adequate amounts. Bifidobacteria have been widely tested as a therapeutic strategy in the prevention and treatme...

  • Article
  • Open Access
2 Citations
2,732 Views
15 Pages

A Micro-Scale Analytical Method for Determining Glycogen Turnover by NMR and FTMS

  • Timothy L. Scott,
  • Juan Zhu,
  • Teresa A. Cassel,
  • Sara Vicente-Muñoz,
  • Penghui Lin,
  • Richard M. Higashi,
  • Andrew N. Lane and
  • Teresa W.-M. Fan

18 August 2022

Glycogen is a readily deployed intracellular energy storage macromolecule composed of branched chains of glucose anchored to the protein glycogenin. Although glycogen primarily occurs in the liver and muscle, it is found in most tissues, and its meta...

  • Review
  • Open Access
15 Citations
4,280 Views
17 Pages

α/β-Hydrolase Domain-Containing 6 (ABHD6)— A Multifunctional Lipid Hydrolase

  • Lisa-Maria Pusch,
  • Lina Riegler-Berket,
  • Monika Oberer,
  • Robert Zimmermann and
  • Ulrike Taschler

18 August 2022

α/β-hydrolase domain-containing 6 (ABHD6) belongs to the α/β-hydrolase fold superfamily and was originally discovered in a functional proteomic approach designed to discover monoacylglycerol (MAG) hydrolases in the mouse brain d...

  • Article
  • Open Access
20 Citations
3,695 Views
21 Pages

Mechanism Analysis of Metabolic Fatty Liver on Largemouth Bass (Micropterus salmoides) Based on Integrated Lipidomics and Proteomics

  • Moyong Xue,
  • Ting Yao,
  • Min Xue,
  • Frédéric Francis,
  • Yuchang Qin,
  • Ming Jia,
  • Junguo Li and
  • Xu Gu

17 August 2022

Metabolic fatty liver disease caused by high-starch diet restricted the intensive and sustainable development of carnivorous fish such as largemouth bass. In this study, the combination liver proteomic and lipidomic approach was employed to investiga...

  • Article
  • Open Access
8 Citations
2,139 Views
20 Pages

17 August 2022

Native South Africans make use of Helichrysum aureonitens Sch. Bip. extracts for the treatment of a variety of infections and they are important in traditional medicinal preparations. This study investigated the effect of seasonal variation and geogr...

  • Article
  • Open Access
12 Citations
3,615 Views
17 Pages

17 August 2022

Due to the numerous adverse effects of synthetic drugs, researchers are currently studying traditional medicinal plants to find alternatives for diabetes treatment. Eucalyptus citriodora is known to be used as a remedy for various illnesses, includin...

  • Article
  • Open Access
11 Citations
2,918 Views
21 Pages

17 August 2022

Pedunculate oak (Quercus robur L.) is an economically important forest-forming species in Poland that produces seeds that are sensitive to desiccation; therefore, short-lived seeds are classified as recalcitrant. Such seeds display active metabolism...

  • Article
  • Open Access
11 Citations
4,272 Views
20 Pages

Predicting Hypertension Subtypes with Machine Learning Using Targeted Metabolites and Their Ratios

  • Smarti Reel,
  • Parminder S. Reel,
  • Zoran Erlic,
  • Laurence Amar,
  • Alessio Pecori,
  • Casper K. Larsen,
  • Martina Tetti,
  • Christina Pamporaki,
  • Cornelia Prehn and
  • Jerzy Adamski
  • + 19 authors

16 August 2022

Hypertension is a major global health problem with high prevalence and complex associated health risks. Primary hypertension (PHT) is most common and the reasons behind primary hypertension are largely unknown. Endocrine hypertension (EHT) is another...

  • Article
  • Open Access
12 Citations
3,460 Views
22 Pages

LDL Promotes Disorders in β-Cell Cholesterol Metabolism, Implications on Insulin Cellular Communication Mediated by EVs

  • Lizbeth Guevara-Olaya,
  • Brenda Chimal-Vega,
  • César Yahel Castañeda-Sánchez,
  • Leslie Y. López-Cossio,
  • Angel Pulido-Capiz,
  • Octavio Galindo-Hernández,
  • Raúl Díaz-Molina,
  • Josefina Ruiz Esparza-Cisneros and
  • Victor García-González

16 August 2022

Dyslipidemia is described as a hallmark of metabolic syndrome, promoting a stage of metabolic inflammation (metainflammation) that could lead to misbalances in energetic metabolism, contributing to insulin resistance, and modifying intracellular chol...

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Metabolites - ISSN 2218-1989