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Metabolites, Volume 11, Issue 10

October 2021 - 65 articles

Cover Story: Anemia and disturbances of iron metabolism were investigated in a cohort of 645 consecutive COVID-19 patients hospitalized at the Innsbruck University Hospital. Pre-existing anemia was associated with increased risk for in-hospital death. Moreover, the decline in hemoglobin and transferrin levels during hospital stay was more pronounced in patients with signs of hyperinflammation upon admission, the latter being associated with a nearly two-fold higher risk for new onset anemia within one week. A more distinct decrease in hemoglobin levels was observed in subjects with severe disease, and new-onset anemia was associated with a higher risk for ICU admission. Hemoglobin, ferritin, and transferrin levels normalized in a median of 122 days after discharge from hospital.View this paper
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Articles (65)

  • Article
  • Open Access
5 Citations
2,963 Views
13 Pages

Analytical Methodology for a Metabolome Atlas of Goat’s Plasma, Milk and Feces Using 1H-NMR and UHPLC-HRMS

  • Cécile Martias,
  • Julie Gatien,
  • Léa Roch,
  • Nadine Baroukh,
  • Sylvie Mavel,
  • Antoine Lefèvre,
  • Frédéric Montigny,
  • Laurent Schibler,
  • Patrick Emond and
  • Lydie Nadal-Desbarats

4 October 2021

Metabolomics has been increasingly used in animal and food sciences. Animal health is one of the most important factor that can also alter animal integrity and welfare. Some studies have already investigated the link between health and metabolic prof...

  • Article
  • Open Access
7 Citations
2,842 Views
10 Pages

Differences of Phenylalanine Concentrations in Dried Blood Spots and in Plasma: Erythrocytes as a Neglected Component for This Observation

  • Dorothea Haas,
  • Jana Hauke,
  • Kathrin V. Schwarz,
  • Lucia Consalvi,
  • Friedrich K. Trefz,
  • Nenad Blau,
  • Georg F. Hoffmann,
  • Peter Burgard,
  • Sven F. Garbade and
  • Jürgen G. Okun

3 October 2021

Monitoring phenylalanine (Phe) concentrations is critical for the management of phenylketonuria (PKU). This can be done in dried blood spots (DBS) or in EDTA plasma derived from capillary or venous blood. Different techniques are used to measure Phe,...

  • Article
  • Open Access
11 Citations
4,058 Views
11 Pages

MSCAT: A Machine Learning Assisted Catalog of Metabolomics Software Tools

  • Jonathan Dekermanjian,
  • Wladimir Labeikovsky,
  • Debashis Ghosh and
  • Katerina Kechris

2 October 2021

The bottleneck for taking full advantage of metabolomics data is often the availability, awareness, and usability of analysis tools. Software tools specifically designed for metabolomics data are being developed at an increasing rate, with hundreds o...

  • Article
  • Open Access
20 Citations
3,455 Views
13 Pages

Clinical Predictors of Mortality and Critical Illness in Patients with COVID-19 Pneumonia

  • Maamoun Basheer,
  • Elias Saad,
  • Rechnitzer Hagai and
  • Nimer Assy

2 October 2021

Early identification of patients with COVID-19 who will develop severe or critical disease symptoms is important for delivering proper and early treatment. We analyzed demographic, clinical, immunological, hematological, biochemical and radiographic...

  • Article
  • Open Access
7 Citations
2,833 Views
13 Pages

Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity

  • Kaho Takaishi,
  • Takaya Oshima,
  • Hikari Eto,
  • Misuzu Nishihira,
  • Son Tien Nguyen,
  • Ryosuke Ochi,
  • Naoto Fujita and
  • Susumu Urakawa

1 October 2021

This study aimed to investigate the influence of childhood exercise and detraining on brown adipose tissue (BAT) whitening in obesity. Four-week-old male Long-Evans Tokushima Otsuka (LETO) rats (n = 9) and Otsuka Long-Evans Tokushima Fatty (OLETF) ra...

  • Article
  • Open Access
10 Citations
3,685 Views
20 Pages

30 September 2021

Lipids play a critical role in the skin as components of the epidermal barrier and as signaling and antimicrobial molecules. Atopic dermatitis in dogs is associated with changes in the lipid composition of the skin, but whether these precede or follo...

  • Article
  • Open Access
10 Citations
3,302 Views
17 Pages

Urinary Metabolome Analyses of Patients with Acute Kidney Injury Using Capillary Electrophoresis-Mass Spectrometry

  • Rintaro Saito,
  • Akiyoshi Hirayama,
  • Arisa Akiba,
  • Yushi Kamei,
  • Yuyu Kato,
  • Satsuki Ikeda,
  • Brian Kwan,
  • Minya Pu,
  • Loki Natarajan and
  • Hibiki Shinjo
  • + 4 authors

30 September 2021

Acute kidney injury (AKI) is defined as a rapid decline in kidney function. The associated syndromes may lead to increased morbidity and mortality, but its early detection remains difficult. Using capillary electrophoresis time-of-flight mass spectro...

  • Feature Paper
  • Review
  • Open Access
72 Citations
7,961 Views
25 Pages

New Advances in Tissue Metabolomics: A Review

  • Michelle Saoi and
  • Philip Britz-McKibbin

30 September 2021

Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical medicine while also providing better understanding of the underlying mechanisms of chronic diseases. Clinical metabolomic studies largely rely on human biofluids...

  • Article
  • Open Access
8 Citations
2,904 Views
12 Pages

Association of Dietary Nutrient Intake with Early Age-Related Macular Degeneration in Japanese-Americans

  • Ayaka Edo,
  • Yunialthy Dwia Pertiwi,
  • Kazuyuki Hirooka,
  • Shun Masuda,
  • Muhammad Irfan Kamaruddin,
  • Masahide Yanagi,
  • Akiko Nagao,
  • Haruya Ohno,
  • Masayasu Yoneda and
  • Yoshiaki Kiuchi

30 September 2021

Lifestyle factors may be associated with the development of age-related macular degeneration (AMD), in addition to demographic and genetic factors. The purpose of this cross-sectional study is to elucidate the association between nutrient intake and...

  • Article
  • Open Access
1 Citations
2,464 Views
18 Pages

30 September 2021

Hull rot disease of almond (Prunus dulcis), caused by the fungus Rhizopus stolonifer, is prevalent in well maintained orchards where trees are provided plenty of water and nitrogen to increase the growth and yield. The predominantly grown variety Non...

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Metabolites - ISSN 2218-1989