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Metabolites, Volume 11, Issue 10

October 2021 - 65 articles

Cover Story: Anemia and disturbances of iron metabolism were investigated in a cohort of 645 consecutive COVID-19 patients hospitalized at the Innsbruck University Hospital. Pre-existing anemia was associated with increased risk for in-hospital death. Moreover, the decline in hemoglobin and transferrin levels during hospital stay was more pronounced in patients with signs of hyperinflammation upon admission, the latter being associated with a nearly two-fold higher risk for new onset anemia within one week. A more distinct decrease in hemoglobin levels was observed in subjects with severe disease, and new-onset anemia was associated with a higher risk for ICU admission. Hemoglobin, ferritin, and transferrin levels normalized in a median of 122 days after discharge from hospital.View this paper
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Articles (65)

  • Review
  • Open Access
28 Citations
6,262 Views
8 Pages

19 October 2021

Traditionally, nutritional epidemiology is the study of the relationship between diet and health and disease in humans at the population level. Commonly, the exposure of interest is food intake. In recent years, nutritional epidemiology has moved fro...

  • Communication
  • Open Access
6 Citations
2,855 Views
9 Pages

Metabolomics Differences of Glycine max QTLs Resistant to Soybean Looper

  • Maryam Yousefi-Taemeh,
  • Jie Lin,
  • Demian R. Ifa,
  • Wayne Parrott and
  • Nik Kovinich

19 October 2021

Quantitative trait loci (QTLs) E and M are major soybean alleles that confer resistance to leaf-chewing insects, and are particularly effective in combination. Flavonoids and/or isoflavonoids are classes of plant secondary metabolites that previous s...

  • Article
  • Open Access
3 Citations
3,217 Views
10 Pages

Modulation of Plasma and Milk Sphingolipids in Dairy Cows Fed High-Starch Diets

  • Jorge Eduardo Rico,
  • Eveline C. Sandri,
  • Andrea Celemín Sarmiento,
  • Janie Lévesque,
  • Ákos Kenéz and
  • Daniel E. Rico

19 October 2021

Bovine milk is a significant source of sphingolipids, dietary compounds that can exert anti-inflammatory actions, and which can modulate the host’s microbiome. Because sphingolipid synthesis can be modified by diet, we hypothesized that dietary condi...

  • Article
  • Open Access
16 Citations
4,686 Views
19 Pages

Metabolomics Reveals Heterogeneity in the Chemical Composition of Green and White Spears of Asparagus (A. officinalis)

  • Eirini Pegiou,
  • Qingrui Zhu,
  • Paraskevas Pegios,
  • Ric C. H. De Vos,
  • Roland Mumm and
  • Robert D. Hall

16 October 2021

Green and white asparagus are quite different crops but can be harvested from the same plant. They have distinct morphological differences due to their mode of cultivation and they are characterised by having contrasting appearance and flavour. Signi...

  • Review
  • Open Access
12 Citations
4,680 Views
14 Pages

15 October 2021

Citrate is a crucial energy sensor that plays a central role in cellular metabolic homeostasis. The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter highly expressed in the mammalian liver with relatively low levels i...

  • Review
  • Open Access
8 Citations
4,539 Views
14 Pages

15 October 2021

I’m Not Dead Yet (Indy) is a fly gene that encodes a homologue of mammalian SLC13A5 plasma membrane citrate transporter. Reducing expression of Indy gene in flies, and its homologues in worms, extends longevity. Indy reduction in flies, worms, mice a...

  • Article
  • Open Access
6 Citations
3,680 Views
16 Pages

Abiotic and Biotic Damage of Microalgae Generate Different Volatile Organic Compounds (VOCs) for Early Diagnosis of Algal Cultures for Biofuel Production

  • Kristen L. Reese,
  • Carolyn L. Fisher,
  • Pamela D. Lane,
  • James D. Jaryenneh,
  • A. Daniel Jones,
  • Matthias Frank and
  • Todd W. Lane

15 October 2021

Open microalgal ponds used in industrial biomass production are susceptible to a number of biotic and abiotic environmental stressors (e.g., grazers, pathogens, pH, temperature, etc.) resulting in pond crashes with high economic costs. Identification...

  • Article
  • Open Access
14 Citations
3,206 Views
16 Pages

Application of Thin-Film Microextraction to Analyze Volatile Metabolites in A549 Cancer Cells

  • Wojciech Filipiak,
  • Karol Jaroch,
  • Paulina Szeliska,
  • Karolina Żuchowska and
  • Barbara Bojko

14 October 2021

Volatile organic compounds (VOCs) have been proposed in the last two decades as biomarkers for disease detection and therapeutic monitoring. Model in vitro experiments with established cell lines are fundamental to clarify whether given VOCs originat...

  • Article
  • Open Access
9 Citations
5,369 Views
13 Pages

Host/Malassezia Interaction: A Quantitative, Non-Invasive Method Profiling Oxylipin Production Associates Human Skin Eicosanoids with Malassezia

  • Yohannes Abere Ambaw,
  • Martin P. Pagac,
  • Antony S. Irudayaswamy,
  • Manfred Raida,
  • Anne K. Bendt,
  • Federico T. Torta,
  • Markus R. Wenk and
  • Thomas L. Dawson

13 October 2021

Malassezia are common components of human skin, and as the dominant human skin eukaryotic microbe, they take part in complex microbe–host interactions. Other phylogenetically related fungi (including within Ustilagomycotina) communicate with their pl...

  • Article
  • Open Access
35 Citations
10,373 Views
11 Pages

Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy

  • Denisa Bojkova,
  • Rui Costa,
  • Philipp Reus,
  • Marco Bechtel,
  • Mark-Christian Jaboreck,
  • Ruth Olmer,
  • Ulrich Martin,
  • Sandra Ciesek,
  • Martin Michaelis and
  • Jindrich Cinatl

13 October 2021

SARS-CoV-2 is causing the coronavirus disease 2019 (COVID-19) pandemic, for which effective pharmacological therapies are needed. SARS-CoV-2 induces a shift of the host cell metabolism towards glycolysis, and the glycolysis inhibitor 2-deoxy-d-glucos...

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Metabolites - ISSN 2218-1989Creative Common CC BY license