Next Article in Journal
Vitamin-D Binding Protein Gene Polymorphisms and Serum 25-Hydroxyvitamin-D in a Turkish Population
Next Article in Special Issue
Genome-Scale Metabolic Modeling Enables In-Depth Understanding of Big Data
Previous Article in Journal
Contribution of Metabolomics to the Understanding of NAFLD and NASH Syndromes: A Systematic Review
Previous Article in Special Issue
Next-Generation Genome-Scale Metabolic Modeling through Integration of Regulatory Mechanisms
 
 
Article

Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models

1
Department of Biomedical Engineering, Computational Biology, Eindhoven University of Technology, Groene Loper 5, 5612 AE Eindhoven, The Netherlands
2
Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Hunter N. B.  Moseley
Metabolites 2021, 11(10), 695; https://doi.org/10.3390/metabo11100695
Received: 21 May 2021 / Revised: 3 September 2021 / Accepted: 23 September 2021 / Published: 12 October 2021
(This article belongs to the Special Issue Genome-Scale Metabolic Models)
Metabolic flexibility is the ability of an organism to adapt its energy source based on nutrient availability and energy requirements. In humans, this ability has been linked to cardio-metabolic health and healthy aging. Genome-scale metabolic models have been employed to simulate metabolic flexibility by computing the Respiratory Quotient (RQ), which is defined as the ratio of carbon dioxide produced to oxygen consumed, and varies between values of 0.7 for pure fat metabolism and 1.0 for pure carbohydrate metabolism. While the nutritional determinants of metabolic flexibility are known, the role of low energy expenditure and sedentary behavior in the development of metabolic inflexibility is less studied. In this study, we present a new description of metabolic flexibility in genome-scale metabolic models which accounts for energy expenditure, and we study the interactions between physical activity and nutrition in a set of patient-derived models of skeletal muscle metabolism in older adults. The simulations show that fuel choice is sensitive to ATP consumption rate in all models tested. The ability to adapt fuel utilization to energy demands is an intrinsic property of the metabolic network. View Full-Text
Keywords: metabolic flexibility; respiratory quotient; energy expenditure metabolic flexibility; respiratory quotient; energy expenditure
Show Figures

Graphical abstract

MDPI and ACS Style

Cabbia, A.; Hilbers, P.A.J.; van Riel, N.A.W. Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models. Metabolites 2021, 11, 695. https://doi.org/10.3390/metabo11100695

AMA Style

Cabbia A, Hilbers PAJ, van Riel NAW. Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models. Metabolites. 2021; 11(10):695. https://doi.org/10.3390/metabo11100695

Chicago/Turabian Style

Cabbia, Andrea, Peter A. J. Hilbers, and Natal A. W. van Riel. 2021. "Simulating Metabolic Flexibility in Low Energy Expenditure Conditions Using Genome-Scale Metabolic Models" Metabolites 11, no. 10: 695. https://doi.org/10.3390/metabo11100695

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop