Special Issue "Metabolomics/Exposome in Precision Nutrition"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 2430

Special Issue Editor

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Interests: metabolism; diabetes; obesity; cognitive development; liver disease; natural products; maternal and child health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of precision nutrition focuses on the study of individuals and their different nutrient requirements and on inter-individual differences in response to nutrients. How individuals responds to nutrients or to a diet is related to their inherited genetics and to the environment. We are all involved in complex interactions with the environment throughout our lifespan, which influence our health and wellness and the way we respond to pharmacological treatments. Each individual is exposed to different nutrients and chemicals depending on one’s diet and on one’s use of supplements, natural products, medications, drugs of abuse, tobacco products, and e-cigarettes. Each of us also comes in contact with different chemicals present in foods and water, at the workplace, at home, or in the garden, and derived from environmental pollution. Collectively and over a lifetime, all these substances leave behind a fingerprint in our organisms at the cellular and molecular levels. Metabolomics is an ideal tool to reveal metabolites and pathway perturbations that arise as a consequence of individual exposures to nutrients, different diets, medications, environmentally relevant chemicals, and other lifestyle factors. Considering the expansion of metabolomics and exposome research in the field of nutrition, this Special Issue aims to present studies applying metabolomics and exposome approaches to identify metabolic perturbations that can inform the development of nutritional interventions. We therefore invite original contributions, reviews, and viewpoint manuscripts based on clinical and preclinical data related to this topic.

Prof. Dr. Susan Sumner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metabolomics
  • Exposome
  • Nutrition
  • Precision Nutrition
  • Metabolic Individuality

Published Papers (1 paper)

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Research

Article
Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants
Metabolites 2021, 11(10), 702; https://doi.org/10.3390/metabo11100702 - 13 Oct 2021
Cited by 4 | Viewed by 1704
Abstract
Cesarean delivery and formula feeding have both been implicated as important factors associated with perturbations to the infant gut microbiome. To investigate the functional metabolic response of the infant gut microbial milieu to these factors, we profiled the stool metabolomes of 121 infants [...] Read more.
Cesarean delivery and formula feeding have both been implicated as important factors associated with perturbations to the infant gut microbiome. To investigate the functional metabolic response of the infant gut microbial milieu to these factors, we profiled the stool metabolomes of 121 infants from a US pregnancy cohort study at approximately 6 weeks of life and evaluated associations with delivery mode and feeding method. Multivariate analysis of six-week stool metabolomic profiles indicated discrimination by both delivery mode and diet. For diet, exclusively breast-fed infants exhibited metabolomic profiles that were distinct from both exclusively formula-fed and combination-fed infants, which were relatively more similar to each other in metabolomic profile. We also identified individual metabolites that were important for differentiating delivery mode groups and feeding groups and metabolic pathways related to delivery mode and feeding type. We conclude based on previous work and this current study that the microbial communities colonizing the gastrointestinal tracts of infants are not only taxonomically, but also functionally distinct when compared according to delivery mode and feeding groups. Further, different sets of metabolites and metabolic pathways define delivery mode and diet metabotypes. Full article
(This article belongs to the Special Issue Metabolomics/Exposome in Precision Nutrition)
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