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Diseases, Volume 7, Issue 2

2019 June - 14 articles

Cover Story: Our case highlights the importance of considering HSV in the differential diagnosis of rectal masses, particularly in HIV-infected individuals with clinical manifestations and endoscopic findings consistent with proctitis. We also advocate the routine use of immunohistochemistry for viral pathogens as part of the diagnostic evaluation of rectal tumors. View this paper.
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Articles (14)

  • Review
  • Open Access
42 Citations
7,703 Views
14 Pages

An increased interest regarding the impact of frailty on the prognosis of cardiovascular disease (CVD) has been observed in the last decade. Frailty is a syndrome characterized by a reduced biological reserve that increases the vulnerability of an in...

  • Article
  • Open Access
43 Citations
8,467 Views
10 Pages

Preoperatory Anxiety in Patients Undergoing Cardiac Surgery

  • José Prado-Olivares and
  • Elena Chover-Sierra

Anxiety is a feeling of discomfort produced in face of an unknown event, as an impending cardiac surgery, that can lead to inconveniences in the intervention and subsequent recovery. Being the purpose of this research to analyze pre-surgical anxiety,...

  • Article
  • Open Access
15 Citations
4,344 Views
15 Pages

Clinical Impact of the Increase in Immunosuppressive Cell-Related Gene Expression in Urine Sediment during Intravesical Bacillus Calmette-Guérin

  • Makito Miyake,
  • Shunta Hori,
  • Sayuri Ohnishi,
  • Takuya Owari,
  • Kota Iida,
  • Kenta Ohnishi,
  • Yosuke Morizawa,
  • Daisuke Gotoh,
  • Yoshitaka Itami and
  • Kiyohide Fujimoto
  • + 7 authors

Background: The aim of this study is to evaluate the clinical impact of intravesical Bacillus Calmette-Guérin (BCG)-induced changes in blood/urinary immune markers. Methods: Time-course changes in blood/urinary clinical parameters and mRNA exp...

  • Communication
  • Open Access
3,081 Views
3 Pages

Epigenetics—Shedding Light on the Path Ahead for Material Sciences

  • Anne Krüger-Genge,
  • Olivia Mauger,
  • Joachim Storsberg and
  • Christian Schmidt

The harmonious regulation of bodily function is a necessity for healthy individuals. Looking from the viewpoint of material sciences, one can only marvel at the cellular factories, their renewal, and the overall control of messaging and control of re...

  • Communication
  • Open Access
45 Citations
6,788 Views
13 Pages

Stenotrophomonas maltophilia has been recognized as an emerging nosocomial pathogen in invasive infections of immunocompromised, severely debilitated patients with significant underlying illnesses. The first-choice drug in these infections is sulfame...

  • Article
  • Open Access
7 Citations
4,502 Views
16 Pages

Electrochemical Methodology for Evaluating Skin Oxidative Stress Status (SOSS)

  • Pincemail Joël,
  • Kaci Mouna-Messaouda,
  • Cheramy-Bien Jean-Paul,
  • Defraigne Jean-Olivier and
  • Meziane Smail

For the purpose of human disease prevention, several methods have been developed, and are still developing, to assess the oxidative stress status (OSS) of individuals. In the present paper, we describe an approach based on electrochemical detection a...

  • Case Report
  • Open Access
13 Citations
6,158 Views
8 Pages

Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis

  • Lourdes Roman-Malo,
  • Beatriz Bullon,
  • Manuel de Miguel and
  • Pedro Bullon

Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival hereditary fibromatosis w...

  • Case Report
  • Open Access
4 Citations
5,423 Views
4 Pages

A Rare Adverse Event of Rhabdomyolysis Caused by Sacubitril/Valsartan

  • Prashanth Rawla,
  • Jeffrey Pradeep Raj,
  • Sajid Melvin George,
  • Pavani Nathala and
  • Anantha R. Vellipuram

Rhabdomyolysis is caused by extensive damage to skeletal muscles resulting in elevated creatine phosphokinase (CPK), Lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), leading to life-threatening consequences like acute renal failure,...

  • Interesting Images
  • Open Access
8 Citations
10,335 Views
4 Pages

Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer

  • Folusakin Ayoade,
  • Jose Armando Gonzales Zamora and
  • Youley Tjendra

Herpes simplex virus (HSV) is the leading cause of proctitis in HIV-infected individuals. However, no cases of rectal masses secondary to HSV infection have been reported to date. Herein, we present the case of a 45-year-old man with HIV infection wh...

  • Article
  • Open Access
9 Citations
5,015 Views
11 Pages

Pertussis (“whooping cough”) is a re-emerging disease with increasing incidence among fully vaccinated individuals. We explored the genetic diversity of five Bordetella pertussis proteins used to generate the subunit vaccine across ancestral and newl...

  • Article
  • Open Access
20 Citations
6,395 Views
11 Pages

Progressive Immunodeficiency with Gradual Depletion of B and CD4+ T Cells in Immunodeficiency, Centromeric Instability and Facial Anomalies Syndrome 2 (ICF2)

  • Georgios Sogkas,
  • Natalia Dubrowinskaja,
  • Anke K. Bergmann,
  • Jana Lentes,
  • Tim Ripperger,
  • Mykola Fedchenko,
  • Diana Ernst,
  • Alexandra Jablonka,
  • Robert Geffers and
  • Faranaz Atschekzei
  • + 2 authors

Immunodeficiency, centromeric instability and facial anomalies syndrome 2 (ICF2) is a rare autosomal recessive primary immunodeficiency disorder. So far, 27 patients have been reported. Here, we present three siblings with ICF2 due to a homozygous ZB...

  • Article
  • Open Access
5 Citations
4,662 Views
16 Pages

Psychometric Properties, Factor Structure, and Evidence for Measurement Invariance in the Greek Version of the Disgust Scale-Revised (DS-R)

  • Theodoros Chalimourdas,
  • Silia Vitoratou,
  • Efstathia Matsouka,
  • Dimitra Anna Owens,
  • Leto Kalogeraki,
  • Iraklis Mourikis,
  • Nikolaos Vaidakis,
  • Maria Tzinieri-Kokkosi,
  • Artemios Pehlivanidis and
  • Charalambos Papageorgiou

The Disgust Scale has been designed to measure disgust propensity—the individual ease in experiencing disgust. The present study aimed to explore the validity, reliability, the factor structure, and the measurement invariance of the Greek versi...

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Diseases - ISSN 2079-9721