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Epidemiological Trends and Resistance Associated with Stenotrophomonas maltophilia Bacteremia: A 10-Year Retrospective Cohort Study in a Tertiary-Care Hospital in Hungary

by Márió Gajdács 1,2,* and Edit Urbán 2
1
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary
2
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Diseases 2019, 7(2), 41; https://doi.org/10.3390/diseases7020041
Received: 9 May 2019 / Revised: 29 May 2019 / Accepted: 31 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Infectious Disease Epidemiology)
Stenotrophomonas maltophilia has been recognized as an emerging nosocomial pathogen in invasive infections of immunocompromised, severely debilitated patients with significant underlying illnesses. The first-choice drug in these infections is sulfamethoxazole-trimethoprim (SMX/TMP), and resistance to this antimicrobial is a daunting challenge for clinicians. The aim of this study was to assess the prevalence of S. maltophilia bacteremia and SMX/TMP-resistance levels at a tertiary-care university hospital. A total of 175 episodes of S. maltophilia bacteremia were identified (2008–2012: n = 82, 2013–2017: n = 93; p = 0.061), 52% of affected patients were 60 years of age, and had recent surgery, severe injuries or underlying conditions (malignant hematologic diseases and solid tumors) in their history. Sixteen percent of isolates were resistant to SMX/TMP (2008–2012: n = 13.8%, 2013–2017: n = 17.2%; p = 0.076), and out of the resistant strains, 32.7% were also resistant to levofloxacin and colistin. Our findings on the SMX/TMP-resistance were similar to global literature data. View Full-Text
Keywords: Stenotrophomonas maltophilia; bacteremia; bloodstream infection; SMX/TMP; sumetrolim-resistance; retrospective; literature review Stenotrophomonas maltophilia; bacteremia; bloodstream infection; SMX/TMP; sumetrolim-resistance; retrospective; literature review
MDPI and ACS Style

Gajdács, M.; Urbán, E. Epidemiological Trends and Resistance Associated with Stenotrophomonas maltophilia Bacteremia: A 10-Year Retrospective Cohort Study in a Tertiary-Care Hospital in Hungary. Diseases 2019, 7, 41.

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