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Electrochemical Methodology for Evaluating Skin Oxidative Stress Status (SOSS)

Department of Cardiovascular Surgery/CREDEC, Antioxidant Nutrition and Health Platform, University of Liège and CHU, Sart Tilman, 4000 Liège, Belgium
Institut Européen des Antioxydants, Oxystress Technologies, 1 rue Victor de Lespinats, 54230 Neuves-Maisons, France
Author to whom correspondence should be addressed.
Diseases 2019, 7(2), 40;
Received: 29 March 2019 / Revised: 10 May 2019 / Accepted: 22 May 2019 / Published: 27 May 2019
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For the purpose of human disease prevention, several methods have been developed, and are still developing, to assess the oxidative stress status (OSS) of individuals. In the present paper, we describe an approach based on electrochemical detection able to evaluate skin oxidative stress status (SOSS) as a PAOT (Pouvoir AntiOxydant Total)-Skin Score®. Normal reference values for the PAOT-Skin Score® were: 0–62.94 (n = 263). Intra- and inter-assay coefficients of variation were, respectively, 12.47 ± 4.29% and 7.0 ± 2.5%. Our technology showed increased skin antioxidant activity following topical application of reduced coeznyme Q10 cream or vitamin C intake as orange juice or supplements. Moreover, we found significant correlations between some blood oxidative stress biomarkers and the PAOT-Skin Score® (γ-tocopherol/α-tocopherol ratio (r = 0.43, p = 0.020); copper (r = −0.42, p = 0.022); copper/zinc ratio (r = −0.49, p = 0.006), and lipid peroxides (r = −0.43, p = 0.002)). In addition to being non–invasive, the present electrochemical methodology is also not expensive, fast, and easy to use. View Full-Text
Keywords: oxidative stress; skin; electrochemical detection; PAOT-Skin Score® oxidative stress; skin; electrochemical detection; PAOT-Skin Score®

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Joël, P.; Mouna-Messaouda, K.; Jean-Paul, C.-B.; Jean-Olivier, D.; Smail, M. Electrochemical Methodology for Evaluating Skin Oxidative Stress Status (SOSS). Diseases 2019, 7, 40.

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