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Open AccessCase Report

Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis

1
Department of Periodontology, Facultad de Odontologia Universidad de Sevilla, c/Avicena s/n, 41009 Sevilla, Spain
2
Department of Cytology and Normal Histology and Pathologogy, Facultad de Medicina, Universidad de Sevilla, Avda. Sánchez Pizjuán s/n, 41009 Sevilla, Spain
*
Author to whom correspondence should be addressed.
Diseases 2019, 7(2), 39; https://doi.org/10.3390/diseases7020039
Received: 2 April 2019 / Revised: 14 May 2019 / Accepted: 24 May 2019 / Published: 25 May 2019
(This article belongs to the Section Rare Syndrome)
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Abstract

Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival hereditary fibromatosis were treated, and gingival biopsies were obtained. A histological study revealed dense fibrous tissue, basal lamina disruption, and epithelial cell migration into the connective tissue. Fibroblasts were cultured from the father and daughter and compared with those from a healthy control patient. The results of the biochemical analysis showed increased collagen synthesis, reduced antioxidant CoQ10 content, and high levels of lipid peroxidation. Additionally, fibroblasts culture incubation with the oxidant H2O2 increased collagen levels that have been reduced by the addition of the antioxidant CoQ10. We conclude that some fibroblasts metabolic alterations play a significant role in initiating and maintaining persistent fibrotic tissue. Oxidative stress influences the fibroblasts collagen production and could play a particular role in the pathogenesis of hereditary gingival fibromatosis. View Full-Text
Keywords: gingival fibromatosis; gingival overgrowth; fibroblasts; collagen; oxidative stress; antioxidants gingival fibromatosis; gingival overgrowth; fibroblasts; collagen; oxidative stress; antioxidants
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Roman-Malo, L.; Bullon, B.; de Miguel, M.; Bullon, P. Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis. Diseases 2019, 7, 39.

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