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Open AccessCase Report

A Rare Adverse Event of Rhabdomyolysis Caused by Sacubitril/Valsartan

Department of Internal Medicine/Hospitalist, SOVAH Health, Martinsville, VA 24112, USA
Department of Clinical Pharmacology, Seth G.S. Medical College & King Edward Memorial Hospital, Mumbai 400012, India
Department of Medicine/Nephrology, SOVAH Health, Martinsville, VA 24112, USA
Division of Infectious Diseases, University of Louisville, Louisville, KY 40202, USA
Department of Neurology, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
Author to whom correspondence should be addressed.
Diseases 2019, 7(2), 38;
Received: 17 April 2019 / Revised: 12 May 2019 / Accepted: 13 May 2019 / Published: 14 May 2019
PDF [181 KB, uploaded 14 May 2019]


Rhabdomyolysis is caused by extensive damage to skeletal muscles resulting in elevated creatine phosphokinase (CPK), Lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), leading to life-threatening consequences like acute renal failure, cardiac arrhythmias, and hyperthermia. A variety of causes for muscle damage are known, and one of the most common is drug-induced. Statins and many other agents are known to induce muscle damage, but here we report Entresto™ (Sacubitril/Valsartan) induced rhabdomyolysis which has not been previously reported as solely responsible in the literature. View Full-Text
Keywords: rhabdomyolysis; entresto; sacubitril/valsartan; adverse drug reaction rhabdomyolysis; entresto; sacubitril/valsartan; adverse drug reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rawla, P.; Raj, J.P.; George, S.M.; Nathala, P.; Vellipuram, A.R. A Rare Adverse Event of Rhabdomyolysis Caused by Sacubitril/Valsartan. Diseases 2019, 7, 38.

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