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Diseases, Volume 13, Issue 3

March 2025 - 27 articles

Cover Story: Pseudoarthrosis, the failure of normal fracture healing, affects 10–15% of long bone fractures, causing pain, disability, and the need for repeated surgeries. Despite advances in understanding bone healing, diagnostics still rely on clinical and radiographic assessments, lacking precise predictive tools. This review explores the genetic and biological basis of pseudoarthrosis, highlighting key mechanisms such as mesenchymal stromal cell dysfunction, altered BMP signaling, and genetic polymorphisms. It emphasizes the need for future research to develop innovative diagnostics and personalized therapies. View this paper
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Articles (27)

  • Review
  • Open Access
1 Citations
1,230 Views
25 Pages

Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer

  • Sanjana Bana,
  • Sia Daffara,
  • Aastha Dagar,
  • Ashutosh Kumar Tiwari,
  • Kanupriya Medhi,
  • Sagarika Mukherjee,
  • Vivek Uttam,
  • Md Rizwan Ansari,
  • Hardeep Singh Tuli and
  • Vikas Yadav
  • + 1 author

20 March 2025

Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers ea...

  • Article
  • Open Access
742 Views
9 Pages

Early Evaluation of the Short Physical Performance Battery in Hospitalized Patients with Chronic Kidney Disease Predicts Long-Term Hospitalization

  • Takashi Amari,
  • Eiji Kubo,
  • Yota Kuramochi,
  • Shota Onoda,
  • Kyosuke Fukuda,
  • Emi Yokoyama,
  • Masami Kimura and
  • Tomoyuki Arai

19 March 2025

Background: The relationship between hospitalization duration and physical function in patients with chronic kidney disease (CKD) has not been thoroughly investigated. This study aimed to determine whether assessment of physical function one week aft...

  • Article
  • Open Access
1,728 Views
22 Pages

Immunomodulatory Effect of Rivaroxaban Nanoparticles Alone and in Combination with Sitagliptin on Diabetic Rat Model

  • Mohamed M. Elbadr,
  • Heba A. Galal,
  • Helal F. Hetta,
  • Hassabelrasoul Elfadil,
  • Fawaz E. Alanazi,
  • Shereen Fawzy,
  • Hashim M. Aljohani,
  • Noura H. Abd Ellah,
  • Marwa F. Ali and
  • Ahmed K. Dyab
  • + 1 author

19 March 2025

Background: Chronic inflammation and immune dysregulation are key drivers of diabetes complications. Rivaroxaban (RX) and sitagliptin (SITA) are established therapies for thromboembolism and glycemic control, respectively. This study evaluated the no...

  • Article
  • Open Access
1 Citations
1,706 Views
24 Pages

Genomic Landscape of Breast Cancer: Study Across Diverse Ethnic Groups

  • Asbiel Felipe Garibaldi-Ríos,
  • Luis E. Figuera,
  • Guillermo Moisés Zúñiga-González,
  • Belinda Claudia Gómez-Meda,
  • Ana María Puebla-Pérez,
  • Alicia Rivera-Cameras,
  • María Teresa Magaña-Torres,
  • José Elías García-Ortíz,
  • Ingrid Patricia Dávalos-Rodríguez and
  • Mónica Alejandra Rosales-Reynoso
  • + 5 authors

17 March 2025

Background: Breast cancer (BC) is the most common cancer among women worldwide, with incidence and mortality rates varying across ethnic groups due to sociodemographic, clinicopathological, and genomic differences. This study aimed to characterize th...

  • Article
  • Open Access
864 Views
14 Pages

16 March 2025

Background: Patients with vertebral metastases often experience spinal instability, chronic pain, and psychological distress, all of which can significantly reduce quality of life. Spinal instability, measured by the Spinal Instability Neoplastic Sco...

  • Article
  • Open Access
1,893 Views
9 Pages

Surgical Treatment of Enchondromas of the Hand: Our Experience in Curettage Only and Early Mobilization

  • Silvia Pietramala,
  • Giuseppe Rovere,
  • Camilla Ravaioli,
  • Ciro Mignano,
  • Amarildo Smakaj,
  • Andrea Fidanza,
  • Pasquale Farsetti,
  • Lorenzo Rocchi and
  • Camillo Fulchignoni

16 March 2025

(1) Background: Enchondroma is one of the most common primary tumors of the hand. Usually asymptomatic, it can present with pain, deformity, and sometimes pathologic fractures. Surgical treatment is advised in these cases. Curettage is the basic trea...

  • Article
  • Open Access
1,291 Views
12 Pages

An Application for Spatial Frailty Models: An Exploration with Data on Fungal Sepsis in Neonates

  • Palaniyandi Paramasivam,
  • Nagaraj Jaganathasamy,
  • Srinivasan Ramalingam,
  • Vasantha Mahalingam,
  • Selvam Nagarajan,
  • Fayaz Ahamed Shaik,
  • Sundarakumar Karuppasamy,
  • Adhin Bhaskar,
  • Padmanaban Srinivasan and
  • Tamizhselvan Manoharan
  • + 2 authors

14 March 2025

Background: Globally, neonatal fungal sepsis (NFS) is a leading cause of neonatal mortality, particularly among vulnerable populations in neonatal intensive care units (NICU). The use of spatial frailty models with a Bayesian approach to identify hot...

  • Systematic Review
  • Open Access
1 Citations
2,149 Views
14 Pages

13 March 2025

Background: Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments, including balance deficits, gait disturbances, and postural instability. Given the limitations of pharmacological treatments, a...

  • Article
  • Open Access
1 Citations
1,134 Views
18 Pages

Evaluating Osteotomy Accuracy in Mandibular Reconstruction: A Preliminary Study Using Custom Cutting Guides and Virtual Reality

  • Claudia Borbon,
  • Andrea Novaresio,
  • Oreste Iocca,
  • Francesca Nonis,
  • Sandro Moos,
  • Enrico Vezzetti,
  • Guglielmo Ramieri and
  • Emanuele Zavattero

13 March 2025

Background: Mandibular reconstruction has evolved significantly since its inception in the early 1900s. Currently, the fibula free flap (FFF) is considered the gold standard for mandibular and maxillary reconstructions, particularly for extensive def...

  • Review
  • Open Access
1 Citations
3,808 Views
32 Pages

11 March 2025

Symptoms of depression represent a significant burden to patients with breast cancer, not only because of the psychological stress associated with their diagnosis, but also because of the adverse effects of its treatment. We reviewed the clinical tri...

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Diseases - ISSN 2079-9721