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Diseases, Volume 13, Issue 3

March 2025 - 27 articles

Cover Story: Pseudoarthrosis, the failure of normal fracture healing, affects 10–15% of long bone fractures, causing pain, disability, and the need for repeated surgeries. Despite advances in understanding bone healing, diagnostics still rely on clinical and radiographic assessments, lacking precise predictive tools. This review explores the genetic and biological basis of pseudoarthrosis, highlighting key mechanisms such as mesenchymal stromal cell dysfunction, altered BMP signaling, and genetic polymorphisms. It emphasizes the need for future research to develop innovative diagnostics and personalized therapies. View this paper
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Articles (27)

  • Article
  • Open Access
2 Citations
1,770 Views
10 Pages

11 March 2025

Background/Objectives: Locally advanced and metastatic leiomyosarcoma (LMS) is an aggressive cancer with limited treatment options. This single-institution, retrospective study evaluated the efficacy of first-line chemotherapy regimens in patients wi...

  • Article
  • Open Access
1,189 Views
15 Pages

Lifestyle and Biochemical Parameters That May Hamper Immune Responses in Pediatric Patients After Immunization with the BNT162b2 mRNA COVID-19 Vaccine

  • Anthie Damianaki,
  • Antonios Marmarinos,
  • Margaritis Avgeris,
  • Dimitrios Gourgiotis,
  • Elpis-Athina Vlachopapadopoulou,
  • Marietta Charakida,
  • Maria Tsolia and
  • Lydia Kossiva

10 March 2025

Background: The aim of this study was to evaluate whether increased body mass index (BMI) and biochemical and lifestyle parameters linked to obesity and smoke exposure disrupt immune responses of children and adolescents following vaccination with th...

  • Article
  • Open Access
1 Citations
3,689 Views
9 Pages

The Influence of Occupational Factors on Contact Dermatitis in Symptomatic Healthcare Workers: A Patch Test Study

  • Cristiana Ferrari,
  • Giuseppina Somma,
  • Viola Giovinazzo,
  • Margherita Iarossi,
  • Michele Treglia,
  • Margherita Pallocci,
  • Luca Di Giampaolo,
  • Andrea Magrini and
  • Luca Coppeta

Healthcare workers (HCWs) are frequently exposed to a variety of chemical agents, which can result in the development of allergic or irritant contact dermatitis. The present study aimed to assess the prevalence of skin sensitization among HCWs who pr...

  • Communication
  • Open Access
1,411 Views
11 Pages

Background: Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peak...

  • Review
  • Open Access
3 Citations
3,372 Views
29 Pages

The Genetic and Biological Basis of Pseudoarthrosis in Fractures: Current Understanding and Future Directions

  • Amalia Kotsifaki,
  • Georgia Kalouda,
  • Sousanna Maroulaki,
  • Athanasios Foukas and
  • Athanasios Armakolas

Pseudoarthrosis—the failure of normal fracture healing—remains a significant orthopedic challenge affecting approximately 10–15% of long bone fractures, and is associated with significant pain, prolonged disability, and repeated sur...

  • Article
  • Open Access
2,212 Views
14 Pages

In and Outpatients Bacteria Antibiotic Resistances in Positive Urine Cultures from a Tertiary Care Hospital in the Western Part of Romania—A Cross-Sectional Study

  • Nicu Olariu,
  • Monica Licker,
  • Lazar Chisavu,
  • Flavia Chisavu,
  • Adalbert Schiller,
  • Luciana Marc,
  • Oana Albai,
  • Andrei Paunescu,
  • Vlad Tucicovschi and
  • Adelina Mihaescu
  • + 1 author

Background/Objectives: Urinary tract infections (UTI) represent a global problem with implications for mortality and morbidity. Published data present different bacterial incidences and different antibiotic resistance. The objective of our study is t...

  • Article
  • Open Access
759 Views
13 Pages

28 February 2025

Background. The study goal was to assess the mortality effect of carotid vascular calcifications (VC), of fibroblast growth factor 23 (FGF-23), mineral markers, and comorbidities in hemodialysis (HD) patients. Methods. The influence of carotid VC sev...

  • Article
  • Open Access
2 Citations
4,496 Views
17 Pages

Optimal Timing of Colostomy Reversal Following Hartmann’s Procedure: A Retrospective Analysis of Postoperative Outcomes

  • Constantin Popazu,
  • Dragoș Voicu,
  • Dorel Firescu,
  • Ionica Grigore,
  • Alexandra Toma and
  • Răzvan Petru Derihaci

28 February 2025

Background/Objectives: Hartmann’s procedure is commonly employed to manage complications of acute sigmoid diverticulitis, such as perforation or abscess formation. However, determining the optimal timing for colostomy reversal remains a topic o...

  • Review
  • Open Access
3 Citations
8,926 Views
14 Pages

26 February 2025

Background: The varicella-zoster virus is a highly contagious human herpesvirus that primarily causes varicella (chickenpox) as an initial infection, targeting T cells, neurons, as well as skin cells, and can later reactivate to cause herpes zoster (...

  • Article
  • Open Access
2 Citations
2,307 Views
12 Pages

25 February 2025

Background and Objectives: Cervical cancer places substantial burdens on physical and psychosocial health. This study evaluated changes in quality of life (QoL) and perceived stress in patients with cervical cancer before and six months after initiat...

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Diseases - ISSN 2079-9721