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Diseases, Volume 12, Issue 9

September 2024 - 32 articles

Cover Story: Obesity is a chronic disease known to be associated with several medical and psychosocial comorbidities, as well as adverse alterations in terms of body composition. Currently, different strategies are available and used for the management of obesity; one of these is the anti-obesity drugs strategy. This strategy is in continuous evolvement and advancement, determining a new era of obesity treatment. In particular, Tirzepatide a new drug that has been recently developed, showed a high effectiveness in terms of weight loss and was also shown to have beneficial effects in terms of obesity comorbidities that go beyond weight loss, such as improvements in type 2 diabetes and cardiovascular diseases. However, despite this fact, little is known about the effect of this drug on body composition compartments during weight loss in people with obesity. View this paper
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Articles (32)

  • Review
  • Open Access
10 Citations
4,627 Views
18 Pages

Mitochondrial Dysfunction in Systemic Lupus Erythematosus: Insights and Therapeutic Potential

  • Anastasia V. Poznyak,
  • Nikolay A. Orekhov,
  • Alexey V. Churov,
  • Irina A. Starodubtseva,
  • Dmitry F. Beloyartsev,
  • Tatiana I. Kovyanova,
  • Vasily N. Sukhorukov and
  • Alexander N. Orekhov

23 September 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by the presence of various serum autoantibodies and multi-system effects, predominantly affecting young female patients. The pathogenesis of SLE involves a combination...

  • Brief Report
  • Open Access
1,716 Views
7 Pages

Whole Exome Sequencing of Adult Indians with Apparently Acquired Aplastic Anaemia: Initial Experience at Tertiary Care Hospital

  • Sudhir Mehta,
  • Krishna Mohan Medicherla,
  • Sandhya Gulati,
  • Nidhi Sharma,
  • Rabia Parveen,
  • Ashwani Kumar Mishra,
  • Sonal Gupta and
  • Prashanth Suravajhala

23 September 2024

Aplastic anaemia (AA) is a rare hypocellular bone marrow disease with a large number of mutations in the telomerase reverse transcriptase gene (TERT), leading to bone marrow failure. We used our benchmarked whole exome sequencing (WES) pipeline to id...

  • Review
  • Open Access
23 Citations
9,292 Views
13 Pages

Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Syndrome Management: A Narrative Review

  • Silvano Dragonieri,
  • Andrea Portacci,
  • Vitaliano Nicola Quaranta,
  • Pierluigi Carratu,
  • Zsofia Lazar,
  • Giovanna Elisiana Carpagnano and
  • Andras Bikov

23 September 2024

Background: Obstructive Sleep Apnea (OSA) is a prevalent disorder characterized by repetitive upper airway obstructions during sleep, leading to intermittent hypoxia and sleep fragmentation. Current treatments, particularly Continuous Positive Airway...

  • Article
  • Open Access
4,970 Views
13 Pages

The Effect of Organic Vegetable Mixed Juice on Blood Circulation and Intestine Flora: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

  • Yun-Ha Lee,
  • Jae-Ho Lee,
  • Soo-Min Jeon,
  • Il-Kyu Park,
  • Hyun-Bin Jang,
  • Soo-A Kim,
  • Soo-Dong Park,
  • Jae-Jung Shim,
  • Seong-Soo Hong and
  • Jae-Hwan Lee

23 September 2024

Epidemiological evidence suggests that fruit and vegetable intake significantly positively affects cardiovascular health. Since vegetable juice is more accessible than raw vegetables, it attracts attention as a health functional food for circulatory...

  • Article
  • Open Access
3 Citations
2,190 Views
12 Pages

18 September 2024

Background: The purpose of this study is to evaluate the effectiveness of Defocus Incorporated Multiple Segments (DIMSs) in slowing myopia progression in pediatric patients as a function of age. Methods: This was a non-randomized experimenter-masked...

  • Article
  • Open Access
1 Citations
2,694 Views
17 Pages

Circulating Interleukins as Biomarkers in Non-Small Cell Lung Cancer Patients: A Pilot Study Compared to Normal Individuals

  • Wei-Wen Lim,
  • Jason H. Leung,
  • Chen Xie,
  • Angelina W. T. Cheng,
  • Liping Su,
  • Luh-Nah Lum,
  • Aishah Toh,
  • Siew-Ching Kong,
  • Angela M. Takano and
  • Derek J. Hausenloy
  • + 1 author

18 September 2024

Identifying biomarkers in non-small cell lung cancer (NSCLC) can improve diagnosis and patient stratification. We evaluated plasmas and sera for interleukins (IL)-11, IL-6, IL-8, IL-17A, and IL-33 as biomarkers in primary NSCLC patients undergoing su...

  • Review
  • Open Access
27 Citations
20,004 Views
21 Pages

Neurobiological Implications of Chronic Stress and Metabolic Dysregulation in Inflammatory Bowel Diseases

  • Aleksandar Sic,
  • Kiana Cvetkovic,
  • Eshanika Manchanda and
  • Nebojsa Nick Knezevic

18 September 2024

Chronic stress is a significant factor affecting modern society, with profound implications for both physical and mental health. Central to the stress response is cortisol, a glucocorticoid hormone produced by the adrenal glands. While cortisol relea...

  • Article
  • Open Access
3 Citations
2,356 Views
11 Pages

The Simultaneous Use of Bladder Epicheck® and Urinary Cytology Can Improve the Sensitivity and Specificity of Diagnostic Follow-Up of Urothelial Lesions: Up-to-Date Data from a Multi-Institutional Cohort

  • Ludovica Pepe,
  • Vincenzo Fiorentino,
  • Cristina Pizzimenti,
  • Giuseppe Riganati,
  • Mariausilia Franchina,
  • Marina Micali,
  • Fernanda Russotto,
  • Antonio Ieni,
  • Giovanni Tuccari and
  • Guido Fadda
  • + 2 authors

18 September 2024

Background/Objectives: Bladder cancer is a prevalent urinary system malignancy and urinary cytology is widely used for its screening and follow-up. A novel diagnostic tool called Bladder Epicheck® (BE) is increasingly being used for monitoring th...

  • Article
  • Open Access
1 Citations
1,802 Views
11 Pages

Comparison of Superselective Renal Artery Embolization versus Retroperitoneal Laparoscopic Partial Nephrectomy in Ruptured Hemorrhagic Renal Angiomyolipoma: A Single-Center Study

  • Zhaoyang Li,
  • Lu Yang,
  • Huitang Yang,
  • Tonghe Zhang,
  • Yandong Cai,
  • Zhan Jiang,
  • Guoju Fan,
  • Kaiqiang Wang,
  • Bo Chen and
  • Hongwei Zhang
  • + 2 authors

16 September 2024

Purpose: To analyze the clinical efficacy of superselective renal artery embolization and retroperitoneal laparoscopic partial nephrectomy for the treatment of ruptured hemorrhagic renal angiomyolipoma and to provide a reference for the selection of...

  • Article
  • Open Access
1 Citations
1,322 Views
11 Pages

Increased Distress in Neurooncological Patients, a Monocentric Longitudinal Study: When to Screen Which Patient?

  • Franziska Staub-Bartelt,
  • Julia Steinmann,
  • Maren Wienand,
  • Michael Sabel and
  • Marion Rapp

16 September 2024

Objective: Neurooncological patients are well-known to experience an increased psycho-oncological burden with a negative impact on distress, therapy adherence, quality of life, and finally survival. But still, psycho-oncological screening and support...

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Diseases - ISSN 2079-9721