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Diseases, Volume 12, Issue 7

July 2024 - 34 articles

Cover Story: This study introduces a first-of-its-kind novel method for designing personalized peptide vaccines for cancer, using RNA sequencing to detect prevalent mutations in patient tumors. We focused on highly mutated genes, processed RNAseq data for read alignment and variant calling using our Python tool, SCGeneID. This tool also aligns RNAseq data against the UCSC hg38 reference, identifying target genes using chromosomes and loci. We designed a personalized vaccine for pancreatic ductal adenocarcinoma (PDAC), targeting highly prevalent gene mutations in PDAC patients. Our approach involved predicting peptide–MHC binding affinity, and selecting the top epitopes based on our established vaccine design principles. Validation was achieved by matching mutated genes found in a reference study, confirming the efficacy of our vaccine design method. View this paper
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Articles (34)

  • Article
  • Open Access
2 Citations
1,412 Views
10 Pages

22 July 2024

We use this study to analyze the trends in in-hospital length of stay, total hospital charges, and mortality among adult patients with a primary diagnosis of adult-onset still’s disease (AOSD). We used the 2016–2019 National Inpatient Sam...

  • Case Report
  • Open Access
1 Citations
1,874 Views
10 Pages

Surgical Approach and Considerations for Compressive Thoracic Intraspinal Osteochondroma in Familial Hereditary Multiple Exostosis

  • Corneliu Toader,
  • Antonio-Daniel Corlatescu,
  • Nicolaie Dobrin,
  • Razvan-Adrian Covache-Busuioc,
  • Horia Petre Costin and
  • Alexandru Vlad Ciurea

19 July 2024

Introduction: Hereditary multiple exostosis or hereditary multiple osteochondromas is a very rare clinical condition. Usually, these lesions tend to occur in the pediatric population, remaining silent until adulthood. Moreover, current studies show a...

  • Case Report
  • Open Access
1,616 Views
8 Pages

Nerve Sheath Myxoma in Pregnancy: A Case Report

  • Elena De Chiara,
  • Valerio Gaetano Vellone,
  • Jacopo Ferro,
  • Chiara Trambaiolo Antonelli,
  • Liliana Piro,
  • Stefano Avanzini,
  • Valentina Prono,
  • Andrea Beccaria,
  • Monica Muraca and
  • Ramona Tallone

18 July 2024

Nerve sheath myxoma (NSM) is a rare benign peripheral nerve sheath tumor that affects young adults. NSMs are asymptomatic, slow-growing swellings located in the upper extremities, more rarely in the lower extremities. Given the high risk of recurrenc...

  • Article
  • Open Access
6 Citations
2,697 Views
9 Pages

Upregulation of TET2 and Resistance to DNA Methyltransferase (DNMT) Inhibitors in DNMT1-Deleted Cancer Cells

  • Angelo B. A. Laranjeira,
  • Dat Nguyen,
  • Lorraine C. Pelosof,
  • James H. Doroshow and
  • Sherry X. Yang

18 July 2024

Background: Ten-eleven-translocation (TET) 2 is a member of the TET family of proteins (TET1-3). DNMT1 gene deletion confers resistance to DNA methyltransferase (DNMT) inhibitors in colorectal, breast, and ovarian cancer cells. Currently, the effect...

  • Article
  • Open Access
2,458 Views
10 Pages

Enzalutamide Prolonged the Duration of Drug Use in Comparison to Abiraterone Acetate and Cabazitaxel after Upfront Docetaxel: A Large Japanese Database Study

  • Katsuya Yamaguchi,
  • Takashi Kawahara,
  • Akihito Hashizume,
  • Kimito Ousaka,
  • Koichi Uemura,
  • Yusuke Ito,
  • Hiroki Ito,
  • Kazuhide Makiyama and
  • Hiroji Uemura

18 July 2024

Introduction: In the United States, a total of 268,490 men were found to have prostate cancer in 2022, thus making it the most common cancer in men, accounting for 27% of all cancers in the male population. Among all cancers in men, it was the fifth...

  • Article
  • Open Access
1,454 Views
12 Pages

Thrombotic Long-Term Consequences of SARS-CoV-2 Infection in Patients with Compensated Cirrhosis: A Propensity Score-Matched Analysis of a U.S. Database

  • Mark Ayoub,
  • Carol Faris,
  • Tajana Juranovic,
  • Rafi Aibani,
  • Morgan Koontz,
  • Harleen Chela,
  • Nadeem Anwar and
  • Ebubekir Daglilar

17 July 2024

Background: Cirrhosis causes an imbalance in the coagulation pathway and leads to a tendency for both bleeding and clotting. SARS-CoV-2 has been reported to be associated with a hypercoagulable state. This study examines SARS-CoV-2’s impact on...

  • Systematic Review
  • Open Access
2 Citations
1,999 Views
15 Pages

Prevalence of Leishmaniasis among Blood Donors: A Systematic Review and Meta-Analysis

  • Maria Kantzanou,
  • Evangelos Kostares,
  • Georgia Kostare,
  • Evangelia Papagiannopoulou,
  • Michael Kostares and
  • Athanasios Tsakris

17 July 2024

Our study seeks to provide a comprehensive assessment of leishmaniasis prevalence among blood donors, employing rigorous methodologies to inform public health initiatives and transfusion safety measures. A thorough literature search was conducted usi...

  • Review
  • Open Access
7 Citations
14,805 Views
13 Pages

Gestational Trophoblastic Disease: Complete versus Partial Hydatidiform Moles

  • Jeffrey Gonzalez,
  • Meagan Popp,
  • Stephanie Ocejo,
  • Alvaro Abreu,
  • Hisham F. Bahmad and
  • Robert Poppiti

17 July 2024

Hydatidiform moles, including both complete and partial moles, constitute a subset of gestational trophoblastic diseases characterized by abnormal fertilization resulting in villous hydrops and trophoblastic hyperplasia with or without embryonic deve...

  • Article
  • Open Access
3 Citations
3,261 Views
13 Pages

Quality of Life Assessment Using the WHOQOL-BREF Survey in Hospitalized Patients with Alcohol Use Disorder from Romania

  • Melania Lavinia Bratu,
  • Dorel Sandesc,
  • Teodora Anghel,
  • Liana Dehelean,
  • Mariana Bondrescu,
  • Felix Bratosin and
  • Raluca Tudor

16 July 2024

This cross-sectional analysis aimed to assess the quality of life (QoL) among hospitalized patients with alcohol use disorder (AUD) in Romania, utilizing the WHOQOL survey. Conducted from January to December 2023 in the Psychiatry Clinic of the &ldqu...

  • Review
  • Open Access
1 Citations
8,153 Views
13 Pages

COVID-19 and Prostatitis: A Review of Current Evidence

  • Datesh Daneshwar,
  • Yemin Lee and
  • Abid Nordin

15 July 2024

Coronavirus disease 2019 (COVID-19), a highly contagious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a global health threat. The virus enters host cells by binding with angiotensin-converting enzyme 2 (...

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Diseases - ISSN 2079-9721