Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
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Author to whom correspondence should be addressed.
Biology 2020, 9(8), 213; https://doi.org/10.3390/biology9080213
Received: 30 June 2020
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Revised: 30 July 2020
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Accepted: 6 August 2020
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Published: 7 August 2020
(This article belongs to the Special Issue ATP-dependent Chromatin Remodeler)
Eukaryotic genomes are pervasively transcribed, producing both coding and non-coding RNAs (ncRNAs). ncRNAs are diverse and a critical family of biological molecules, yet much remains unknown regarding their functions and mechanisms of regulation. ATP-dependent nucleosome remodeling complexes, in modifying chromatin structure, play an important role in transcriptional regulation. Recent findings show that ncRNAs regulate nucleosome remodeler activities at many levels and that ncRNAs are regulatory targets of nucleosome remodelers. Further, a series of recent screens indicate this network of regulatory interactions is more expansive than previously appreciated. Here, we discuss currently described regulatory interactions between ncRNAs and nucleosome remodelers and contextualize their biological functions.
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Keywords:
chromatin; nucleosome remodeling; non-coding RNA (ncRNA); transcription; lncRNA; eRNA; SWI/SNF; CHD; ISWI; INO80
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MDPI and ACS Style
Patty, B.J.; Hainer, S.J. Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship. Biology 2020, 9, 213. https://doi.org/10.3390/biology9080213
AMA Style
Patty BJ, Hainer SJ. Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship. Biology. 2020; 9(8):213. https://doi.org/10.3390/biology9080213
Chicago/Turabian StylePatty, Benjamin J., and Sarah J. Hainer. 2020. "Non-Coding RNAs and Nucleosome Remodeling Complexes: An Intricate Regulatory Relationship" Biology 9, no. 8: 213. https://doi.org/10.3390/biology9080213
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