Previous Article in Journal
Prevalence and Types of Inappropriate Antibiotics Prescribing Among Dialysis Patients: A Systematic Review
Previous Article in Special Issue
Targeting Bacterial Biofilms on Medical Implants: Current and Emerging Approaches
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antibiotics
Volume 14
Issue 10
10.3390/antibiotics14101050
antibiotics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Microbiological and Clinical Evaluation of the Efficacy of a Chemical Desiccant Agent in Non-Surgical Periodontal Treatment: A Randomized Controlled Clinical Trial

by
Alessia Pardo
1,
Gabriele Brancato
1,
Annarita Signoriello
1,*,
Elena Messina
1,*,
Giovanni Corrocher
1,
Valentina Bellopede
2,
Gloria Burlacchini
3,
Caterina Signoretto
3 and
Giorgio Lombardo
1
1
Dentistry and Maxillofacial Surgery Unit, Department of Surgery, Dentistry, Pediatrics and Gynecology (DIPSCOMI), University of Verona, Piazzale L.A. Scuro, 10, 37134 Verona, Italy
2
G.B Rossi, Integrated University Hospital of Verona, Piazzale L.A. Scuro, 37134 Verona, Italy
3
Diagnostic and Public Health Department, University of Verona, 37134 Verona, Italy
*
Authors to whom correspondence should be addressed.
Antibiotics 2025, 14(10), 1050; https://doi.org/10.3390/antibiotics14101050
Submission received: 8 September 2025 / Revised: 11 October 2025 / Accepted: 17 October 2025 / Published: 20 October 2025
(This article belongs to the Special Issue Antibacterial and Antibiofilm Properties of Biomaterial)
Versions Notes

Abstract

Background: This randomized clinical trial compared the effects of topical irrigation with a desiccant agent (HybenX Oral Tissue Decontaminant, HBX) combined with full-mouth ultrasonic debridement as well as scaling and root planing (FMUD-SRP) versus conventional non-surgical periodontal therapy (US-SRP). Methods: Three quadrants per patient with probing pocket depth (PPD) ≥ 5 mm were randomly assigned to (i) the control group (US-SRP only), (ii) test group 1 (HBX + US-SRP at baseline, HBX 1T (one time)), or (ii) test group 2 (HBX + US-SRP across three sessions, HBX 3T (three times)). Clinical parameters included probing pocket depth (PPD), bleeding on probing (BOP), plaque index (PI), gingival recession (REC), and Clinical Attachment Level (CAL), recorded at baseline (Tbase), 45 days (T45d), and 90 days (T90d). Microbiological sampling was conducted for all sites at Tbase, T45d, and T90d to assess periodontal pathogens. HBX-treated sites received gel application for 60 s, followed by a saline rinse and US-SRP. Results: Significant differences were found between groups in PPD (p = 0.04) and CAL (p = 0.02) at T45d versus Tbase, while BOP, PI, and REC showed no significant inter-group differences at T45d. The HBX 3T group demonstrated greater pathogen reduction compared to the control and HBX 1T groups, except for one bacterial species. Conclusions: All treatments improved clinical and microbiological parameters. Even if single and triple applications of HBX showed similar clinical results, the repeated application achieved greater bacterial reduction.
Keywords: desiccant agent; periodontopathogens bacteria; non-surgical therapy; randomized clinical trial desiccant agent; periodontopathogens bacteria; non-surgical therapy; randomized clinical trial

Share and Cite

MDPI and ACS Style

Pardo, A.; Brancato, G.; Signoriello, A.; Messina, E.; Corrocher, G.; Bellopede, V.; Burlacchini, G.; Signoretto, C.; Lombardo, G. Microbiological and Clinical Evaluation of the Efficacy of a Chemical Desiccant Agent in Non-Surgical Periodontal Treatment: A Randomized Controlled Clinical Trial. Antibiotics 2025, 14, 1050. https://doi.org/10.3390/antibiotics14101050

AMA Style

Pardo A, Brancato G, Signoriello A, Messina E, Corrocher G, Bellopede V, Burlacchini G, Signoretto C, Lombardo G. Microbiological and Clinical Evaluation of the Efficacy of a Chemical Desiccant Agent in Non-Surgical Periodontal Treatment: A Randomized Controlled Clinical Trial. Antibiotics. 2025; 14(10):1050. https://doi.org/10.3390/antibiotics14101050

Chicago/Turabian Style

Pardo, Alessia, Gabriele Brancato, Annarita Signoriello, Elena Messina, Giovanni Corrocher, Valentina Bellopede, Gloria Burlacchini, Caterina Signoretto, and Giorgio Lombardo. 2025. "Microbiological and Clinical Evaluation of the Efficacy of a Chemical Desiccant Agent in Non-Surgical Periodontal Treatment: A Randomized Controlled Clinical Trial" Antibiotics 14, no. 10: 1050. https://doi.org/10.3390/antibiotics14101050

APA Style

Pardo, A., Brancato, G., Signoriello, A., Messina, E., Corrocher, G., Bellopede, V., Burlacchini, G., Signoretto, C., & Lombardo, G. (2025). Microbiological and Clinical Evaluation of the Efficacy of a Chemical Desiccant Agent in Non-Surgical Periodontal Treatment: A Randomized Controlled Clinical Trial. Antibiotics, 14(10), 1050. https://doi.org/10.3390/antibiotics14101050

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop