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Open AccessFeature PaperReview

Nanotechnology in Oral Cavity Carcinoma: Recent Trends and Treatment Opportunities

1
Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, 00161 Rome, Italy
2
Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I, “Sapienza” University of Rome, 00161 Rome, Italy
3
Department of Clinical Sciences and Translational Medicine, Tor Vergata University, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Nanomaterials 2019, 9(11), 1546; https://doi.org/10.3390/nano9111546
Received: 9 October 2019 / Revised: 26 October 2019 / Accepted: 28 October 2019 / Published: 31 October 2019
(This article belongs to the Special Issue Nanomaterials and Nanotechnology in Dentistry)
Oral cavity carcinoma (OCC) remains an ongoing public health problem. Emerging nanotechnology provides alternative treatment approaches. This review covers the up-to-date literature in the human OCC treatment field. We explored the growing body of evidence to reveal novel and highly promising diagnostic and therapeutic applications of nanotechnology in this field. Various types of nanoparticles have been tested for applications in OCC. Imaging modalities in addition to nanocarriers are discussed. The encouraging contribution of lymphotropic nanoparticles contrast in the diagnosis of metastatic cervical lymph nodes needs to be confirmed. The development of the sentinel lymph node procedure and photodynamic therapy may lead to breakthrough therapies in order improve clinical outcomes and quality of life. In this perspective, cancer nanotechnology has the potential to revolutionize the treatment of OCC patients. View Full-Text
Keywords: oral cavity cancer; surgery; radiotherapy; nanotechnology; nanoparticle; imaging; diagnostic exam; photodynamic therapy; sentinel lymph node; research oral cavity cancer; surgery; radiotherapy; nanotechnology; nanoparticle; imaging; diagnostic exam; photodynamic therapy; sentinel lymph node; research
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MDPI and ACS Style

De Felice, F.; Cavallini, C.; Barlattani, A.; Tombolini, M.; Brugnoletti, O.; Tombolini, V.; Polimeni, A. Nanotechnology in Oral Cavity Carcinoma: Recent Trends and Treatment Opportunities. Nanomaterials 2019, 9, 1546.

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