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Journal of Functional Biomaterials, Volume 15, Issue 6

June 2024 - 33 articles

Cover Story: Several factors can necessitate delaying regenerative treatments for severe muscle trauma, including infection, management of comorbidities, and the time required for biomanufacturing of the therapeutics themselves. This study investigated using a polyvinyl alcohol-based, in situ-forming muscle void filler (MVF) to provide initial stabilization following volumetric muscle loss injury. These MVFs were removed after four weeks and replaced with minced muscle grafts to promote the regeneration of functional skeletal muscle within the defect. While this multi-stage approach effectively maintained the defect volume and minimized complications, the delayed application of MMGs did not demonstrate significant regenerative benefits. View this paper
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Articles (33)

  • Review
  • Open Access
4 Citations
2,932 Views
28 Pages

Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures

  • Teodora Eliana Petcov,
  • Mihai Straticiuc,
  • Decebal Iancu,
  • Dragoș Alexandru Mirea,
  • Roxana Trușcă,
  • Paul Emil Mereuță,
  • Diana Iulia Savu,
  • George Dan Mogoșanu,
  • Laurențiu Mogoantă and
  • Roxana Cristina Popescu
  • + 2 authors

Nanoparticle (NP)-based solutions for oncotherapy promise an improved efficiency of the anticancer response, as well as higher comfort for the patient. The current advancements in cancer treatment based on nanotechnology exploit the ability of these...

  • Article
  • Open Access
2 Citations
2,455 Views
16 Pages

Novel Resin-Based Antibacterial Root Surface Coating Material to Combat Dental Caries

  • Nader Almutairi,
  • Abdullah Alhussein,
  • Mohammad Alenizy,
  • Ibrahim Ba-Armah,
  • Jirun Sun,
  • Michael D. Weir and
  • Hockin H. K. Xu

Root caries caused by cariogenic bacteria are a burden on a large number of individuals worldwide, especially the elderly. Applying a protective coating to exposed root surfaces has the potential to inhibit the development of caries, thus preserving...

  • Article
  • Open Access
5 Citations
3,295 Views
23 Pages

Development of Novel Antibacterial Ti-Nb-Ga Alloys with Low Stiffness for Medical Implant Applications

  • Rhianna McHendrie,
  • Ngoc Huu Nguyen,
  • Manh Tuong Nguyen,
  • Khosro Fallahnezhad,
  • Krasimir Vasilev,
  • Vi Khanh Truong and
  • Reza Hashemi

With the rising demand for medical implants and the dominance of implant-associated failures including infections, extensive research has been prompted into the development of novel biomaterials that can offer desirable characteristics. This study de...

  • Article
  • Open Access
6 Citations
2,533 Views
14 Pages

In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys

  • Bogdan Istrate,
  • Florina-Daniela Cojocaru,
  • Mădălina-Elena Henea,
  • Vera Balan,
  • Eusebiu-Viorel Șindilar,
  • Liliana Verestiuc,
  • Corneliu Munteanu and
  • Carmen Solcan

The objective of this work was to analyze the in vitro and in vivo tests of a novel Mg-based biodegradable alloy—Mg-0.5%Ca—with various amounts of Zn (0.5, 1, 1.5, 2.0, and 3.0 wt.%). In terms of in vitro biocompatibility, MTT and Calcein...

  • Review
  • Open Access
8 Citations
6,532 Views
18 Pages

Resin-based dental composites, commonly used in dentistry, offer several advantages including minimally invasive application, esthetically pleasing appearance, and good physical and mechanical properties. However, these dental composites can be susce...

  • Article
  • Open Access
3 Citations
2,111 Views
13 Pages

Enhanced Antibacterial Properties of Titanium Surfaces through Diversified Ion Plating with Silver Atom Deposition

  • Everton Granemann Souza,
  • Chiara das Dores do Nascimento,
  • Cesar Aguzzoli,
  • Elena Sarai Baena Santillán,
  • Carlos Enrique Cuevas-Suárez,
  • Patricia da Silva Nascente,
  • Evandro Piva and
  • Rafael Guerra Lund

In this study, we investigate the antibacterial effect of silver atoms implanted into a thin surface layer of titanium at low energies using an alternative ion plating technology called Diversified Ion Plating. Silver atoms were incorporated into tit...

  • Article
  • Open Access
7 Citations
2,560 Views
20 Pages

Silver-Doped Titanium Oxide Layers for Improved Photocatalytic Activity and Antibacterial Properties of Titanium Implants

  • Aya Ali,
  • Likhitha Polepalli,
  • Sheetal Chowdhury,
  • Mary A. Carr,
  • Amol V. Janorkar,
  • Mary E. Marquart,
  • Jason A. Griggs,
  • Joel D. Bumgardner and
  • Michael D. Roach

Titanium has a long history of clinical use, but the naturally forming oxide is not ideal for bacterial resistance. Anodization processes can modify the crystallinity, surface topography, and surface chemistry of titanium oxides. Anatase, rutile, and...

  • Article
  • Open Access
5 Citations
2,462 Views
11 Pages

Osteoinductive Properties of Autologous Dentin: An Ex Vivo Study on Extracted Teeth

  • Giulia Mazzucchi,
  • Alessia Mariano,
  • Giorgio Serafini,
  • Luca Lamazza,
  • Anna Scotto d’Abusco,
  • Alberto De Biase and
  • Marco Lollobrigida

Over the last decades, a variety of biomaterials, ranging from synthetic products to autologous and heterologous grafts, have been recommended to conserve and regenerate bone tissue after tooth extraction. We conducted a biochemical study on ground e...

  • Article
  • Open Access
5 Citations
3,028 Views
19 Pages

Furosemide (FUR) is a diuretic used to relieve edema, congestive heart failure, cirrhosis, end-stage renal disease, and hypertension. FUR is a class IV according to the Biopharmaceutics Classification System. It is practically insoluble in water. Thi...

  • Article
  • Open Access
2 Citations
1,888 Views
13 Pages

A Two-Stage Approach Integrating Provisional Biomaterial-Mediated Stabilization Followed by a Definitive Treatment for Managing Volumetric Muscle Loss Injuries

  • Andrew R. Clark,
  • Jonathan Kulwatno,
  • Sergey S. Kanovka,
  • George J. Klarmann,
  • Claudia E. Hernandez,
  • Roman M. Natoli,
  • Todd O. McKinley,
  • Benjamin K. Potter,
  • Christopher L. Dearth and
  • Stephen M. Goldman

Treatment of volumetric muscle loss (VML) faces challenges due to its unique pathobiology and lower priority in severe musculoskeletal injury management. Consequently, a need exists for multi-stage VML treatment strategies to accommodate delayed inte...

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J. Funct. Biomater. - ISSN 2079-4983