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Journal of Functional Biomaterials, Volume 14, Issue 1

January 2023 - 50 articles

Cover Story: Ebola virus infection in humans is a severe and often fatal disease, which demands effective interventional strategies for its prevention. Microneedle patches, which are made of an array of micron-scale, solid needles that painlessly penetrate into the upper layers of the skin and dissolve to deliver vaccine intradermally, simplify vaccination and can increase vaccine access, especially in resource-constrained or emergency settings. The present study describes a novel technology, which combines ebolavirus glycoprotein antigen with a polyphosphazene-based immunoadjuvant, PCPP in microneedle patches. Skin immunization of mice induced strong, long-lasting antibody responses. Moreover, vaccinated mice were completely protected against lethal mouse-adapted Ebola virus challenge. View this paper
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Articles (50)

  • Review
  • Open Access
12 Citations
5,149 Views
30 Pages

A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease

  • Mehtap Sahiner,
  • Aynur Sanem Yilmaz,
  • Buket Gungor and
  • Nurettin Sahiner

Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases. In particular, the prevalence...

  • Article
  • Open Access
11 Citations
2,936 Views
15 Pages

Characterization and Evaluation of Rapamycin-Loaded Nano-Micelle Ophthalmic Solution

  • Ting Zhang,
  • Chao Wei,
  • Xianggen Wu,
  • Sai Zhang,
  • Fangnan Duan,
  • Xiaolin Qi,
  • Weiyun Shi and
  • Hua Gao

Rapamycin-loaded nano-micelle ophthalmic solution (RAPA-NM) offers a promising application for preventing corneal allograft rejection; however, RAPA-NM has not yet been fully characterized. This study aimed to evaluate the physicochemical properties,...

  • Review
  • Open Access
2 Citations
2,996 Views
21 Pages

Matrices Activated with Messenger RNA

  • Raquel Martinez-Campelo and
  • Marcos Garcia-Fuentes

Over two decades of preclinical and clinical experience have confirmed that gene therapy-activated matrices are potent tools for sustained gene modulation at the implantation area. Matrices activated with messenger RNA (mRNA) are the latest developme...

  • Review
  • Open Access
92 Citations
12,085 Views
29 Pages

Emerging Trends in Advanced Translational Applications of Silver Nanoparticles: A Progressing Dawn of Nanotechnology

  • Shaheen Husain,
  • Aditya Nandi,
  • Faizan Zarreen Simnani,
  • Utsa Saha,
  • Aishee Ghosh,
  • Adrija Sinha,
  • Aarya Sahay,
  • Shailesh Kumar Samal,
  • Pritam Kumar Panda and
  • Suresh K. Verma

Nanoscience has emerged as a fascinating field of science, with its implementation in multiple applications in the form of nanotechnology. Nanotechnology has recently been more impactful in diverse sectors such as the pharmaceutical industry, agricul...

  • Article
  • Open Access
13 Citations
3,361 Views
15 Pages

Enhanced Antibacterial Effect on Zirconia Implant Abutment by Silver Linear-Beam Ion Implantation

  • Yang Yang,
  • Mingyue Liu,
  • Zhen Yang,
  • Wei-Shao Lin,
  • Li Chen and
  • Jianguo Tan

Peri-implant lesions, such as peri-implant mucositis and peri-implantitis, are bacterial-derived diseases that happen around dental implants, compromising the long-term stability and esthetics of implant restoration. Here, we report a surface-modific...

  • Article
  • Open Access
7 Citations
3,107 Views
14 Pages

One-Piece Zirconia Oral Implants for the Support of Three-Unit Fixed Dental Prostheses: Three-Year Results from a Prospective Case Series

  • Ralf-Joachim Kohal,
  • Kirstin Vach,
  • Frank Butz,
  • Benedikt Christopher Spies,
  • Sebastian Berthold Maximilian Patzelt and
  • Felix Burkhardt

The objective was to investigate the clinical and radiological outcome of one-piece zirconia oral implants to support three-unit fixed dental prostheses (FDP) after three years in function. Twenty-seven patients were treated with a total of 54 implan...

  • Article
  • Open Access
8 Citations
3,855 Views
12 Pages

A Novel Hydrophilic, Antibacterial Chitosan-Based Coating Prepared by Ultrasonic Atomization Assisted LbL Assembly Technique

  • Xiaoyu Wang,
  • Yuyang Zhou,
  • Melissa Johnson,
  • Cameron Milne,
  • Sigen A,
  • Yening Li,
  • Wenxin Wang,
  • Nan Zhang and
  • Qian Xu

To explore the potential applicability of chitosan (CTS), we prepared aldehyde chitosan (CTS-CHO) with chitosan and sodium periodate via oxidation reaction and then a chitosan-based hydrophilic and antibacterial coating on the surface of poly (lactic...

  • Review
  • Open Access
47 Citations
8,132 Views
22 Pages

Icariin: A Promising Natural Product in Biomedicine and Tissue Engineering

  • Zahra Seyedi,
  • Mohammad Sadegh Amiri,
  • Vahideh Mohammadzadeh,
  • Alireza Hashemzadeh,
  • Aliakbar Haddad-Mashadrizeh,
  • Mohammad Mashreghi,
  • Mohsen Qayoomian,
  • Mohammad Reza Hashemzadeh,
  • Jesus Simal-Gandara and
  • Mohammad Ehsan Taghavizadeh Yazdi

Among scaffolds used in tissue engineering, natural biomaterials such as plant-based materials show a crucial role in cellular function due to their biocompatibility and chemical indicators. Because of environmentally friendly behavior and safety, gr...

  • Article
  • Open Access
5 Citations
3,154 Views
13 Pages

Acid-Triggered Release of Eugenol and Fluoride by Desensitizing Macro- and Nanoparticles

  • Grigoriy Sereda,
  • Abu Ahammadullah,
  • Nisitha Wijewantha and
  • Yulia Almiron Solano

The modern dentifrice industry needs non-toxic materials able to adhere to dentin, occlude dentinal tubules, hold pharmacons at the surface of dentin, and release them on demand to the location the tooth needs them most. Novel dental materials loaded...

  • Article
  • Open Access
11 Citations
3,758 Views
17 Pages

Combining IVUS + OCT Data, Biomechanical Models and Machine Learning Method for Accurate Coronary Plaque Morphology Quantification and Cap Thickness and Stress/Strain Index Predictions

  • Rui Lv,
  • Liang Wang,
  • Akiko Maehara,
  • Mitsuaki Matsumura,
  • Xiaoya Guo,
  • Habib Samady,
  • Don P. Giddens,
  • Jie Zheng,
  • Gary S. Mintz and
  • Dalin Tang

Assessment and prediction of vulnerable plaque progression and rupture risk are of utmost importance for diagnosis, management and treatment of cardiovascular diseases and possible prevention of acute cardiovascular events such as heart attack and st...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license