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Journal of Functional Biomaterials, Volume 11, Issue 3

2020 September - 22 articles

Cover Story: Over millions of years, nature has produced a wide variety of biological materials optimised for distinct functions. Many of these systems found in biology possess unique surface properties recognised to regulate cell behaviour. Integration of such natural surface properties in biomaterials can bring about novel cell responses and provide greater insights into the processes occurring at the cell–biomaterial interface. Using natural surfaces as templates for bioinspired design can stimulate progress in the field of regenerative medicine, tissue engineering and biomaterials science. This literature review aims to combine the state-of-the-art knowledge in natural and nature-inspired surfaces. View this paper
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Articles (22)

  • Review
  • Open Access
215 Citations
17,498 Views
36 Pages

Bio-Based Electrospun Fibers for Wound Healing

  • Bahareh Azimi,
  • Homa Maleki,
  • Lorenzo Zavagna,
  • Jose Gustavo De la Ossa,
  • Stefano Linari,
  • Andrea Lazzeri and
  • Serena Danti

22 September 2020

Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the...

  • Article
  • Open Access
18 Citations
4,379 Views
20 Pages

Biosynthesis, Characterization, and Biological Activities of Procyanidin Capped Silver Nanoparticles

  • Umar M. Badeggi,
  • Jelili A. Badmus,
  • Subelia S. Botha,
  • Enas Ismail,
  • Jeanine L. Marnewick,
  • Charlene W. J. Africa and
  • Ahmed A. Hussein

19 September 2020

In this study, procyanidin dimers and Leucosidea sericea total extract (LSTE) were employed in the synthesis of silver nanoparticles (AgNPs) and characterized by ultraviolet-visible (UV-Visible) spectroscopy, high-resolution transmission electron mic...

  • Article
  • Open Access
11 Citations
3,267 Views
12 Pages

Development of Bionanocomposites Based on Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate)/PolylActide Blends Reinforced with Cloisite 30B

  • Clément Lacoste,
  • Benjamin Gallard,
  • José-Marie Lopez-Cuesta,
  • Ozlem Ipek Kalaoglu-Altan and
  • Karen De Clerck

16 September 2020

In the present study, poly(3-hydroxybuturate-co-3-hydroxyvalerate) (PHBV) and plasticized polylactide acid (PLA) blends were processed by melt extrusion with different weight ratio (up to 20 wt.% of PHBV). Bionanocomposites were obtained through the...

  • Article
  • Open Access
17 Citations
5,173 Views
13 Pages

Biocompatibility of α-Al2O3 Ceramic Substrates with Human Neural Precursor Cells

  • Akrivi Asimakopoulou,
  • Ioannis Gkekas,
  • Georgia Kastrinaki,
  • Alessandro Prigione,
  • Vasileios T. Zaspalis and
  • Spyros Petrakis

16 September 2020

Background: Biocompatible materials-topography could be used for the construction of scaffolds allowing the three-dimensional (3D) organization of human stem cells into functional tissue-like structures with a defined architecture. Methods: Structura...

  • Article
  • Open Access
19 Citations
5,028 Views
30 Pages

Carbonate Apatite and Hydroxyapatite Formulated with Minimal Ingredients to Deliver SiRNA into Breast Cancer Cells In Vitro and In Vivo

  • Rowshan Ara Islam,
  • Hamed Al-Busaidi,
  • Rahela Zaman,
  • Syafiq Asnawi Zainal Abidin,
  • Iekhsan Othman and
  • Ezharul Hoque Chowdhury

10 September 2020

Introduction: Cancer is one of the top-ranked noncommunicable diseases causing deaths to nine million people and affecting almost double worldwide in 2018. Tremendous advancement in surgery, chemotherapy, radiation and targeted immunotherapy have imp...

  • Article
  • Open Access
58 Citations
7,198 Views
17 Pages

Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application

  • Bahareh Azimi,
  • Lily Thomas,
  • Alessandra Fusco,
  • Ozlem Ipek Kalaoglu-Altan,
  • Pooja Basnett,
  • Patrizia Cinelli,
  • Karen De Clerck,
  • Ipsita Roy,
  • Giovanna Donnarumma and
  • Andrea Lazzeri
  • + 2 authors

Polyhydroxyalkanoates (PHAs) are a family of bio-based polyesters that have found different biomedical applications. Chitin and lignin, byproducts of fishery and plant biomass, show antimicrobial and anti-inflammatory activity on the nanoscale. Due t...

  • Article
  • Open Access
18 Citations
4,546 Views
9 Pages

Collagen films with proton conduction are a candidate of next generation of fuel-cell electrolyte. To clarify a relation between proton conductivity and formation of water networks in the collagen film originating from a tilapia’s scale, we sys...

  • Article
  • Open Access
34 Citations
4,936 Views
13 Pages

Antimicrobial Properties of the Polyaniline Composites against Pseudomonas aeruginosa and Klebsiella pneumoniae

  • Moorthy Maruthapandi,
  • Arumugam Saravanan,
  • John H. T. Luong and
  • Aharon Gedanken

CuO, TiO2, or SiO2 was decorated on polyaniline (PANI) by a sonochemical method, and their antimicrobial properties were investigated for two common Gram-negative pathogens: Pseudomonas aeruginosa (PA) and Klebsiella pneumoniae (KP). Without PANI, Cu...

  • Feature Paper
  • Review
  • Open Access
38 Citations
8,524 Views
20 Pages

Biodegradable Polymeric Micro/Nano-Structures with Intrinsic Antifouling/Antimicrobial Properties: Relevance in Damaged Skin and Other Biomedical Applications

  • Mario Milazzo,
  • Giuseppe Gallone,
  • Elena Marcello,
  • Maria Donatella Mariniello,
  • Luca Bruschini,
  • Ipsita Roy and
  • Serena Danti

Bacterial colonization of implanted biomedical devices is the main cause of healthcare-associated infections, estimated to be 8.8 million per year in Europe. Many infections originate from damaged skin, which lets microorganisms exploit injuries and...

  • Article
  • Open Access
37 Citations
5,587 Views
17 Pages

Electrospun Scaffolds Containing Silver-Doped Hydroxyapatite with Antimicrobial Properties for Applications in Orthopedic and Dental Bone Surgery

  • Thomas E. Paterson,
  • Rui Shi,
  • Jingjing Tian,
  • Caroline J. Harrison,
  • Mailys De Sousa Mendes,
  • Paul V. Hatton,
  • Zhou Li and
  • Ilida Ortega

Preventing the development of osteomyelitis while enhancing bone regeneration is challenging, with relatively little progress to date in translating promising technologies to the clinic. Nanoscale hydroxyapatite (nHA) has been employed as a bone graf...

  • Article
  • Open Access
17 Citations
4,268 Views
11 Pages

Classical extraction methods used for isolation of active substances from plant material are expensive, complicated and often environmentally unfriendly. The ultrasonic assistance micelle-mediated extraction method (UAMME), based on green chemistry p...

  • Review
  • Open Access
7 Citations
6,371 Views
13 Pages

An advancement in preventing secondary caries has been the incorporation of quaternary ammonium containing (QAC) compounds into a composite resin mixture. The permanent positive charge on the monomers allows for electrostatic-based killing of bacteri...

  • Article
  • Open Access
25 Citations
4,870 Views
13 Pages

Effect of Novel Antibacterial Composites on Bacterial Biofilms

  • Rayan B. Yaghmoor,
  • Wendy Xia,
  • Paul Ashley,
  • Elaine Allan and
  • Anne M. Young

Continuing cariogenic bacterial growth demineralizing dentine beneath a composite filling is the most common cause of tooth restoration failure. Novel composites with antibacterial polylysine (PLS) (0, 4, 6, or 8 wt%) in its filler phase were therefo...

  • Article
  • Open Access
55 Citations
6,227 Views
17 Pages

Novel CaF2 Nanocomposites with Antibacterial Function and Fluoride and Calcium Ion Release to Inhibit Oral Biofilm and Protect Teeth

  • Heba Mitwalli,
  • Abdulrahman A. Balhaddad,
  • Rashed AlSahafi,
  • Thomas W. Oates,
  • Mary Anne S. Melo,
  • Hockin H. K. Xu and
  • Michael D. Weir

(1) Background: The objective of this study was to develop a novel dental nanocomposite containing dimethylaminohexadecyl methacrylate (DMAHDM), 2-methacryloyloxyethyl phosphorylcholine (MPC), and nanoparticles of calcium fluoride (nCaF2) for prevent...

  • Article
  • Open Access
3 Citations
3,408 Views
11 Pages

Titanium Nickelide in Midface Fractures Treatment

  • Liudmila Shamanaeva,
  • Ekaterina Diachkova,
  • Pavel Petruk,
  • Kirill Polyakov,
  • Igor Cherkesov and
  • Sergei Ivanov

Background: The question of reconstruction of human tissues and organs with the use of medical materials is still open, because of the accurate requirements for their biological and physical features. The aim of this study was to prove the efficiency...

  • Article
  • Open Access
14 Citations
3,514 Views
10 Pages

Early Polylysine Release from Dental Composites and Its Effects on Planktonic Streptococcus mutans Growth

  • Nikos N. Lygidakis,
  • Elaine Allan,
  • Wendy Xia,
  • Paul F. Ashley and
  • Anne M. Young

The study aim was to assess the effect of incorporating polylysine (PLS) filler at different mass fractions (0.5, 1 and 2 wt%) on PLS release and Streptococcus mutans planktonic growth. Composite containing PLS mass and volume change and PLS release...

  • Communication
  • Open Access
37 Citations
12,017 Views
9 Pages

Poly-l-lactic acid (PLLA), a synthetic, biocompatible, biodegradable polymer, has been safely used in several clinical applications in recent decades. Typically, SculptraTM, the commercially injectable PLLA in the form of microparticles, has been use...

  • Article
  • Open Access
17 Citations
4,541 Views
21 Pages

Interactions of Osteoprogenitor Cells with a Novel Zirconia Implant Surface

  • Thomas Munro,
  • Catherine M. Miller,
  • Elsa Antunes and
  • Dileep Sharma

Background: This study compared the in vitro response of a mouse pre-osteoblast cell line on a novel sandblasted zirconia surface with that of titanium. Material and Methods: The MC3T3-E1 subclone 4 osteoblast precursor cell line was cultured on eith...

  • Feature Paper
  • Article
  • Open Access
6 Citations
3,800 Views
12 Pages

Controlled Release of 5-FU from Chi–DHA Nanoparticles Synthetized with Ionic Gelation Technique: Evaluation of Release Profile Kinetics and Cytotoxicity Effect

  • Mariarosa Ruffo,
  • Ortensia Ilaria Parisi,
  • Francesco Patitucci,
  • Marco Dattilo,
  • Rocco Malivindi,
  • Fabio Amone,
  • Catia Morelli,
  • Alessandra Nigro,
  • Diego Sisci and
  • Francesco Puoci

The ionic gelation technique allows us to obtain nanoparticles able to function as carriers for hydrophobic anticancer drugs, such as 5-fluoruracil (5-FU). In this study, reticulated chitosan– docosahexaenoic acid (Chi–DHAr) nanoparticles...

  • Article
  • Open Access
40 Citations
5,709 Views
13 Pages

Anti-Metastatic Effects of Plant Sap-Derived Extracellular Vesicles in a 3D Microfluidic Cancer Metastasis Model

  • Kimin Kim,
  • Jik-Han Jung,
  • Hye Ju Yoo,
  • Jae-Kyung Hyun,
  • Ji-Ho Park,
  • Dokyun Na and
  • Ju Hun Yeon

Natural medicinal plants have attracted considerable research attention for their potential as effective drugs. The roots, leaves and stems of the plant, Dendropanax morbifera, which is endemic to southern regions of Asia, have long been used as a fo...

  • Review
  • Open Access
13 Citations
6,846 Views
24 Pages

Natural Architectures for Tissue Engineering and Regenerative Medicine

  • Floris Honig,
  • Steven Vermeulen,
  • Amir A. Zadpoor,
  • Jan de Boer and
  • Lidy E. Fratila-Apachitei

The ability to control the interactions between functional biomaterials and biological systems is of great importance for tissue engineering and regenerative medicine. However, the underlying mechanisms defining the interplay between biomaterial prop...

  • Article
  • Open Access
6 Citations
3,634 Views
14 Pages

Extended bone fractures or fractures coexisting with bone disorders can lead to non-unions where surgical intervention is required. Composite drug delivery systems are being used increasingly more in order to treat such defects locally. Alendronate (...

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J. Funct. Biomater. - ISSN 2079-4983