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Journal of Clinical Medicine, Volume 8, Issue 6

June 2019 - 154 articles

Cover Story: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms during community-acquired pneumonia (CAP), while neither clinical data nor guidelines encourage this use. The mechanisms by which NSAID use would entail a complicated course in pneumonia still remain uncertain. The temporal hypothesis and the immunological hypothesis are the two main emerging hypotheses. Current data strongly support an association between NSAID intake during the outpatient treatment of CAP and a complicated course. This should encourage experts and scientific societies to strongly advise against the use of NSAIDs in the management of lower respiratory tract infections. View this paper
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Articles (154)

  • Article
  • Open Access
21 Citations
4,688 Views
14 Pages

Loss of XBP1 Leads to Early-Onset Retinal Neurodegeneration in a Mouse Model of Type I Diabetes

  • Todd McLaughlin,
  • Manhal Siddiqi,
  • Joshua J. Wang and
  • Sarah X. Zhang

Retinal neuronal injury and degeneration is one of the primary manifestations of diabetic retinopathy, a leading cause of vision loss in working age adults. In pathological conditions, including diabetes and some physiological conditions such as agin...

  • Article
  • Open Access
17 Citations
10,564 Views
18 Pages

Pregnant Women’s Risk Perception of the Teratogenic Effects of Alcohol Consumption in Pregnancy

  • Isabel Corrales-Gutierrez,
  • Ramon Mendoza,
  • Diego Gomez-Baya and
  • Fatima Leon-Larios

There is ample evidence of the teratogenic effects of prenatal alcohol exposure, with long-term consequences throughout the entire life cycle. Nevertheless, research on risk perception of alcohol consumption among pregnant women is scarce. In order t...

  • Review
  • Open Access
54 Citations
24,540 Views
22 Pages

Hormonal Contraceptives, Female Sexual Dysfunction, and Managing Strategies: A Review

  • Nerea M. Casado-Espada,
  • Rubén de Alarcón,
  • Javier I. de la Iglesia-Larrad,
  • Berta Bote-Bonaechea and
  • Ángel L. Montejo

In recent decades, hormonal contraceptives (HC) has made a difference in the control of female fertility, taking an unequivocal role in improving contraceptive efficacy. Some side effects of hormonal treatments have been carefully studied. However, t...

  • Article
  • Open Access
36 Citations
5,695 Views
16 Pages

Outcome measures reported by patients, clinicians, and lay-observers can help to tailor treatment plans to meet patients’ needs. This study evaluated orthognathic surgery (OGS) outcomes using pre- and post-OGS patients’ (n = 84) FACE-Q re...

  • Article
  • Open Access
46 Citations
4,152 Views
8 Pages

Multidisciplinary Management of Neuroendocrine Neoplasia: A Real-World Experience from a Referral Center

  • Ludovica Magi,
  • Federica Mazzuca,
  • Maria Rinzivillo,
  • Giulia Arrivi,
  • Emanuela Pilozzi,
  • Daniela Prosperi,
  • Elsa Iannicelli,
  • Paolo Mercantini,
  • Michele Rossi and
  • Patrizia Pizzichini
  • + 5 authors

Purpose: Multidisciplinary approach is widely advised for an effective care of patients with neuroendocrine neoplasia (NEN). Since data on efficacy of multidisciplinary management of NENs patients in referral centers are scanty, this study aimed at a...

  • Article
  • Open Access
37 Citations
4,365 Views
16 Pages

Osteosarcoma is the most common type of bone cancer. Multimodality treatment involving chemotherapy, radiotherapy and surgery is not effective enough to control osteosarcoma. Regorafenib, the oral multi-kinase inhibitor, has been shown to have positi...

  • Article
  • Open Access
21 Citations
4,549 Views
10 Pages

Dysfunctional Coping Mechanisms Contribute to Dry Eye Symptoms

  • Sneh Patel,
  • Elizabeth R Felix,
  • Roy C Levitt,
  • Constantine D. Sarantopoulos and
  • Anat Galor

Dysfunctional coping behaviors, such as catastrophizing, have been implicated in pain severity and chronicity across several pain disorders. However, the impact of dysfunctional coping has not been examined under the context of dry eye (DE). This stu...

  • Review
  • Open Access
41 Citations
5,493 Views
10 Pages

Congenital Heart Defects in Monochorionic Twins: A Systematic Review and Meta-Analysis

  • Manon Gijtenbeek,
  • Maryam R. Shirzada,
  • Arend D. J. Ten Harkel,
  • Dick Oepkes and
  • Monique C. Haak

Monochorionic (MC) twins are at an increased risk of developing congenital heart defects (CHDs) compared to singletons and dichorionic twins. The development of acquired CHDs in this specific group of twins is associated with twin–twin transfus...

  • Review
  • Open Access
18 Citations
6,446 Views
14 Pages

Alteration of Epigenetic Modifiers in Pancreatic Cancer and Its Clinical Implication

  • Yu-Hsuan Hung,
  • Ming-Chuan Hsu,
  • Li-Tzong Chen,
  • Wen-Chun Hung and
  • Mei-Ren Pan

The incidence of pancreatic cancer has considerably increased in the past decade. Pancreatic cancer has the worst prognosis among the cancers of the digestive tract because the pancreas is located in the posterior abdominal cavity, and most patients...

  • Article
  • Open Access
18 Citations
4,984 Views
13 Pages

Shared Decision-Making in Chronic Patients with Polypharmacy: An Interventional Study for Assessing Medication Appropriateness

  • Valle Coronado-Vázquez,
  • Juan Gómez-Salgado,
  • Javier Cerezo-Espinosa de los Monteros,
  • Diego Ayuso-Murillo and
  • Carlos Ruiz-Frutos

Potentially inappropriate medications are associated with polypharmacy and polypathology. Some interventions such as pharmacotherapy reviews have been designed to reduce the prescribing of inappropriate medications. The objective of this study is to...

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J. Clin. Med. - ISSN 2077-0383