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Journal of Clinical Medicine, Volume 8, Issue 6

June 2019 - 154 articles

Cover Story: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms during community-acquired pneumonia (CAP), while neither clinical data nor guidelines encourage this use. The mechanisms by which NSAID use would entail a complicated course in pneumonia still remain uncertain. The temporal hypothesis and the immunological hypothesis are the two main emerging hypotheses. Current data strongly support an association between NSAID intake during the outpatient treatment of CAP and a complicated course. This should encourage experts and scientific societies to strongly advise against the use of NSAIDs in the management of lower respiratory tract infections. View this paper
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Articles (154)

  • Article
  • Open Access
61 Citations
5,631 Views
28 Pages

Few studies have investigated the real-life outcomes of interdisciplinary multimodal pain rehabilitation programs (IMMRP) for chronic pain. This study has four aims: investigate effect sizes (ES); analyse correlation patterns of outcome changes; defi...

  • Article
  • Open Access
36 Citations
8,191 Views
15 Pages

Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA) Concentrations in Patients with Obesity and the Risk of Obstructive Sleep Apnea (OSA)

  • Yana Arlouskaya,
  • Ada Sawicka,
  • Marek Głowala,
  • Joanna Giebułtowicz,
  • Natalia Korytowska,
  • Marek Tałałaj,
  • Grażyna Nowicka and
  • Małgorzata Wrzosek

Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of nitric oxide (NO) synthesis, and play a critical role in the process of endothelial dysfunction, and are considered markers of oxidative stress. The...

  • Article
  • Open Access
7 Citations
3,333 Views
14 Pages

Background: Reduced left ventricular function (LVF) is a predictor for stent-thrombosis. In advanced heart failure (characterized by high NT-proBNP) with an activated coagulation system, coronary events clinically perceived as sudden death or death f...

  • Article
  • Open Access
21 Citations
4,597 Views
11 Pages

Pulmonary Embolism and Coexisting Deep Vein Thrombosis: A Detrimental Association?

  • Elena-Mihaela Cordeanu,
  • Hélène Lambach,
  • Marie Heitz,
  • Julie Di Cesare,
  • Corina Mirea,
  • Alix-Marie Faller,
  • Anne-Cécile Cavaro,
  • Anne-Sophie Frantz,
  • Sebastien Gaertner and
  • Valérie Schini-Kerth
  • + 1 author

Background: The prognostic significance of coexisting deep vein thrombosis (DVT) in acute pulmonary embolism (PE) is controversial. This study aimed to provide routine patient care data on the impact of this association on PE severity and 3-month out...

  • Article
  • Open Access
15 Citations
4,838 Views
16 Pages

Stabilizing Techniques and Guided Imagery for Traumatized Male Refugees in a German State Registration and Reception Center: A Qualitative Study on a Psychotherapeutic Group Intervention

  • Catharina Zehetmair,
  • Inga Tegeler,
  • Claudia Kaufmann,
  • Anne Klippel,
  • Luise Reddemann,
  • Florian Junne,
  • Sabine C. Herpertz,
  • Hans-Christoph Friederich and
  • Christoph Nikendei

Refugees have an increased risk of developing mental health problems. Due to the unstable setting in refugee state registration and reception centers, recommended trauma-focused treatment approaches are often not applicable. For this purpose, we devi...

  • Article
  • Open Access
21 Citations
4,460 Views
10 Pages

25-Hydroxy Vitamin D Detection Using Different Analytic Methods in Patients with Migraine

  • Luca Gallelli,
  • Andzelika Michniewicz,
  • Erika Cione,
  • Aida Squillace,
  • Manuela Colosimo,
  • Corrado Pelaia,
  • Alessia Fazio,
  • Stefania Zampogna,
  • Francesco Peltrone and
  • Rosario Iannacchero
  • + 4 authors

Objectives: The aim of this study was to evaluate the performance of different analytic methods, such as liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), high-performance liquid chromatography-ultraviolet (HPLC-UV), enzyme-link...

  • Article
  • Open Access
18 Citations
3,855 Views
15 Pages

Early Local Inhibition of Club Cell Protein 16 Following Chest Trauma Reduces Late Sepsis-Induced Acute Lung Injury

  • Philipp Störmann,
  • Nils Becker,
  • Jan Tilmann Vollrath,
  • Kernt Köhler,
  • Andrea Janicova,
  • Sebastian Wutzler,
  • Frank Hildebrand,
  • Ingo Marzi and
  • Borna Relja

Blunt thoracic trauma (TxT) deteriorates clinical post-injury outcomes. Ongoing inflammatory changes promote the development of post-traumatic complications, frequently causing Acute Lung Injury (ALI). Club Cell Protein (CC)16, a pulmonary anti-infla...

  • Review
  • Open Access
31 Citations
6,863 Views
17 Pages

Non-Invasive Biomarkers for Celiac Disease

  • Alka Singh,
  • Atreyi Pramanik,
  • Pragyan Acharya and
  • Govind K. Makharia

Once thought to be uncommon, celiac disease has now become a common disease globally. While avoidance of the gluten-containing diet is the only effective treatment so far, many new targets are being explored for the development of new drugs for its t...

  • Article
  • Open Access
20 Citations
6,183 Views
13 Pages

We recently reported the results of a randomized, parallel-group, observer-masked, community-based clinical trial of 132 cognitively normal individuals aged 20–67 with below median aerobic capacity who were randomly assigned to one of two 6-mon...

  • Article
  • Open Access
12 Citations
4,209 Views
8 Pages

Adiponectin, an anti-inflammatory and anti-atherogenic protein, affects glucose metabolism. High serum adiponectin levels are associated with decreased diabetes mellitus (DM) risks. Aortic arterial stiffness (AS) is associated with cardiovascular dis...

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J. Clin. Med. - ISSN 2077-0383