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Open AccessArticle

Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection

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Department of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany
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Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany
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Department of Gastroenterology and Hepatology, University Hospital Essen, 45147 Essen, Germany
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Institute for Interdisciplinary Medicine IFI, 20099 Hamburg, Germany
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Center for HIV and Hepatogastroenterology, 40237 Düsseldorf, Germany
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Department of Gastroenterology and Rheumatology, University Hospital Leipzig, 04103 Leipzig, Germany
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Practice of Internal Medicine, 10777 Berlin, Germany
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Department of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, 55131 Mainz, Germany
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Department of Medicine II, Division of Hepatology, University Hospital Würzburg, 97080 Würzburg, Germany
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Gastroenterology-Hepatology Center, 24105 Kiel, Germany
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Hepato-Gastroenterology, Hopital Brabois- CHU Nancy, 54500 Vandoeuvre-les-Nancy, France
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Practice of Gastroenterology, 65189 Wiesbaden, Germany
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Practice of Hepatology, 44623 Herne, Germany
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Infektiologikum, 60596 Frankfurt, Germany
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BioPredictive, 75007 Paris, France
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Department of Gastroenterology, St. Josefs-Hospital, 65189 Wiesbaden, Germany
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(12), 2101; https://doi.org/10.3390/jcm8122101
Received: 20 October 2019 / Revised: 12 November 2019 / Accepted: 20 November 2019 / Published: 2 December 2019
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection. View Full-Text
Keywords: HBV; non-invasive fibrosis assessment; point shear wave elastography; acoustic radiation force impulse imaging; transient elastography; fibrotest; APRI; FIB-4 HBV; non-invasive fibrosis assessment; point shear wave elastography; acoustic radiation force impulse imaging; transient elastography; fibrotest; APRI; FIB-4
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Graf, C.; Mondorf, A.; Knop, V.; Peiffer, K.-H.; Dietz, J.; Friess, J.; Wedemeyer, H.; Buggisch, P.; Mauss, S.; Berg, T.; Rausch, M.; Sprinzl, M.; Klinker, H.; Hinrichsen, H.; Bronowicki, J.-P.; Haag, S.; Hüppe, D.; Lutz, T.; Poynard, T.; Zeuzem, S.; Friedrich-Rust, M.; Sarrazin, C.; Vermehren, J. Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection. J. Clin. Med. 2019, 8, 2101.

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