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Journal of Clinical Medicine, Volume 7, Issue 1

January 2018 - 10 articles

Cover Story: Irritable bowel syndrome (IBS) is a common condition defined on the basis of presenting symptoms alone. IBS is heterogeneous; it is unlikely that a single factor will explain all instances. Abnormalities in the gut (motility, sensation, immune response, secretion) and brain (abnormal responses to visceral stimuli, co-morbid psychopathology) have been described and led to the development of the paradigm of the gut-brain axis to include the variable contribution of these and other factors in IBS pathogenesis. This axis is now extended to include the gut microbiome—the microbiome-gut-brain axis, based on experiments demonstrating the ability of the microbiome to influence brain function, the demonstration, in IBS, of both a disrupted gut microbiome and clinical benefits from interventions that modify the microbiome. The implications of this novel concept to the assessment and management of IBS are yet to be fully explored. View this paper
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Articles (10)

  • Feature Paper
  • Case Report
  • Open Access
47 Citations
7,581 Views
8 Pages

10 January 2018

Cutaneous squamous cell carcinomas (SCC) affecting the regions of the head and neck can be challenging to resect surgically and refractory to chemotherapy or radiation therapy. Consequently; the treatment of squamous cell carcinomas of the skin is a...

  • Review
  • Open Access
21 Citations
6,819 Views
10 Pages

The Evolving Treatment of Peripheral Arterial Disease through Guideline-Directed Recommendations

  • Ramez Morcos,
  • Boshra Louka,
  • Andrew Tseng,
  • Sanjay Misra,
  • Robert McBane,
  • Heidi Esser and
  • Fadi Shamoun

Peripheral arterial disease (PAD) refers to partial or complete occlusion of one or more non-coronary arteries that leads to compromised blood flow and ischemia. Numerous processes are involved in arterial stenosis, however, atherosclerosis remains t...

  • Feature Paper
  • Article
  • Open Access
40 Citations
9,246 Views
11 Pages

The introduction of the FOLFIRINOX regimen within the last decade marked the first progress in the clinical field of metastatic pancreatic cancer which had not seen any improvements in treatment availability for several years. In a phase III randomiz...

  • Review
  • Open Access
58 Citations
10,369 Views
12 Pages

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases in humans. It is characterized by visceral pain and/or discomfort, hypersensitivity and abnormal motor responses along with change in gut habits. Although the etio-pat...

  • Review
  • Open Access
96 Citations
25,459 Views
8 Pages

Irritable bowel syndrome (IBS) is one of the most common of all medical disorders worldwide and, while for some it represents no more than a nuisance, for others it imposes significant negative impacts on daily life and activities. IBS is a heterogen...

  • Feature Paper
  • Review
  • Open Access
43 Citations
9,313 Views
10 Pages

The Patient-Provider (P-P) relationship is the foundation of medical practice. The quality of this relationship is essential, particularly for the management of chronic illness such as Irritable Bowel Syndrome (IBS), since it correlates with disease...

  • Article
  • Open Access
7 Citations
4,765 Views
7 Pages

Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis

  • Sho Endo,
  • Yoshifumi Saisho,
  • Kei Miyakoshi,
  • Daigo Ochiai,
  • Tadashi Matsumoto,
  • Yoshinaga Kawano,
  • Masanori Mitsuishi,
  • Junichiro Irie,
  • Masami Tanaka and
  • Shu Meguro
  • + 2 authors

Objective: The aim of this study was to clarify the association of maternal factors with perinatal complications in pregnancies complicated with type 1 (T1D) or type 2 diabetes (T2D). Methods: We conducted a retrospective chart review and enrolled 26...

  • Case Report
  • Open Access
15 Citations
5,018 Views
4 Pages

Prevalence of Idiopathic Cyclic Edema in Women with Lower Limb Lymphedema

  • Jose Maria Pereira de Godoy,
  • Henrique Jose Pereira de Godoy,
  • Lívia Maria Pereira de Godoy and
  • Maria De Fatima Guerreiro Godoy

25 December 2017

Cyclic edema is a clinical condition in women that leads to fluid retention in the orthostatic position. The aim of the present study was to evaluate the prevalence of idiopathic cyclic edema in women with lower limb lymphedema. The prevalence of idi...

  • Review
  • Open Access
236 Citations
11,385 Views
25 Pages

Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview

  • Do Hyung Kim,
  • Tiaosi Xing,
  • Zhibin Yang,
  • Ronald Dudek,
  • Qun Lu and
  • Yan-Hua Chen

22 December 2017

The epithelial mesenchymal transition (EMT) plays a central role in both normal physiological events (e.g., embryonic development) and abnormal pathological events (e.g., tumor formation and metastasis). The processes that occur in embryonic developm...

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J. Clin. Med. - ISSN 2077-0383