Table of Contents
J. Clin. Med., Volume 7, Issue 1 (January 2018)
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Cover Story (view full-size image) Irritable bowel syndrome (IBS) is a common condition defined on the basis of presenting symptoms [...] Read more. Irritable bowel syndrome (IBS) is a common condition defined on the basis of presenting symptoms alone. IBS is heterogeneous; it is unlikely that a single factor will explain all instances. Abnormalities in the gut (motility, sensation, immune response, secretion) and brain (abnormal responses to visceral stimuli, co-morbid psychopathology) have been described and led to the development of the paradigm of the gut-brain axis to include the variable contribution of these and other factors in IBS pathogenesis. This axis is now extended to include the gut microbiome—the microbiome-gut-brain axis, based on experiments demonstrating the ability of the microbiome to influence brain function, the demonstration, in IBS, of both a disrupted gut microbiome and clinical benefits from interventions that modify the microbiome. The implications of this novel concept to the assessment and management of IBS are yet to be fully explored. View this paper