Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis
Abstract
:1. Introduction
2. Subjects and Methods
3. Results
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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All | Women with T1D | Women with T2D | p | |
---|---|---|---|---|
n (%) | 26 (100) | 15 (58) | 11 (42) | |
Age (years) | 35.7 ± 5.1 | 34.0 ± 5.8 | 38.0 ± 2.7 | 0.04 |
Disease duration (years) | 11.7 ± 9.6 | 17.7 ± 7.9 | 3.6 ± 4.2 | <0.01 |
Nullipara, n (%) | 19 (73.1) | 12 (80.0) | 7 (63.6) | 0.35 |
Pre-gestational body weight (kg) | 60.8 ± 4.7 | 54.2 ± 7.6 | 69.6 ± 13.8 | <0.01 |
Pre-gestational BMI (kg/m2) | 23.8 ± 4.8 | 21.0 ± 2.4 | 27.5 ± 4.9 | <0.01 |
Obesity, n (%) | 6 (23.1) | 0 (0) | 6 (54.5) | <0.01 |
Hypertension, n (%) | 4 (15.4) | 1 (6.7) | 3 (27.2) | 0.15 |
Diabetic retinopathy, n (%) | 10 (38.5) | 7 (46.7) | 3 (27.2) | 0.32 |
Pre-gestational serum creatinine (mg/dL) | 0.69 ± 0.39 | 0.66 ± 0.2 | 0.74 ± 0.6 | 0.61 |
Chronic kidney disease (eGFR < 60 mL/min), n (%) | 2 (7.7) | 1 (6.7) | 1 (9.1) | 0.82 |
Pre-gestational HbA1c (%) | 7.4 ± 1.7 | 7.6 ± 1.8 | 7.1 ± 1.6 | 0.52 |
Insulin dose before pregnancy (U/day) | 26.0 ± 22.7 | 38.9 ± 15.3 | 9.5 ± 20.0 | <0.01 |
Weight gain during pregnancy (kg) | 9.1 ± 5.7 | 11.6 ± 5.1 | 5.8 ± 4.9 | <0.01 |
Increment in insulin during pregnancy (U/day) | 18.6 ± 33.5 | 5.4 ± 17.4 | 35.4 ± 41.7 | 0.02 |
Women with T1D (n = 15) | Women with T2D (n = 11) |
---|---|
LGA (6) | PIH (4) |
Neonatal hypoglycemia (5) | Urgent Caesarean section (3) |
Urgent Caesarean section (5) | Neonatal hypoglycemia (2) |
PIH (2) | SGA (1) |
Worsening maternal renal function (2) | LGA (1) |
Fetal dysfunction (1) | Fetal structural anomaly (1) |
Preterm birth <34 weeks of gestation (1) |
Perinatal Complications (+) | Perinatal Complications (−) | p | |
---|---|---|---|
n (%) | 11 (73) | 4 (27) | |
Age (years) | 35.2 ± 4.9 | 30.8 ± 6.5 | 0.20 |
Disease duration (years) | 19.5 ± 7.1 | 12.5 ± 7.4 | 0.13 |
Pre-gestational BMI (kg/m2) | 21.3 ± 2.1 | 20.4 ± 2.8 | 0.54 |
Pre-gestational serum creatinine (mg/dL) | 0.70 ± 0.2 | 0.60 ± 0.1 | 0.53 |
Pre-gestational HbA1c (%) | 8.2 ± 1.7 | 6.0 ± 0.3 | 0.03 |
HbA1c at delivery (%) | 6.7 ± 0.8 | 6.0 ± 0.6 | 0.13 |
GA at delivery (%) | 17.3 ± 2.2 | 16.5 ± 2.1 | 0.57 |
Mean HbA1c during pregnancy (%) | 7.2 ± 0.9 | 6.0 ± 0.6 | 0.04 |
Weight gain during pregnancy (kg) | 12.5 ± 5.6 | 9.1 ± 2.3 | 0.27 |
Increment in insulin during pregnancy (U/day) | 2.7 ± 18 | 12.3 ± 13 | 0.38 |
Perinatal Complications (+) | Perinatal Complications (−) | p | |
---|---|---|---|
n (%) | 6 (55) | 5 (45) | |
Age (years) | 39.3 ± 2.5 | 36.2 ± 1.9 | 0.07 |
Disease duration (years) | 5.2 ± 4.6 | 1.8 ± 1.6 | 0.19 |
Pre-gestational BMI (kg/m2) | 31.1 ± 3.3 | 23.2 ± 1.0 | 0.001 |
Pre-gestational serum creatinine (mg/dL) | 0.8 ± 0.7 | 0.7 ± 0.1 | 0.65 |
Pre-gestational HbA1c (%) | 7.0 ± 1.0 | 7.2 ± 2.0 | 0.89 |
HbA1c at delivery (%) | 5.9 ± 0.2 | 6.2 ± 1.2 | 0.55 |
GA at delivery (%) | 13.3 ± 1.7 | 14.5 ± 2.6 | 0.42 |
Mean HbA1c during pregnancy (%) | 6.0 ± 0.5 | 6.4 ± 1.7 | 0.67 |
Weight gain during pregnancy (kg) | 4.3 ± 2.7 | 7.7 ± 5.8 | 0.27 |
Increment in insulin during pregnancy (U/day) | 31.7 ± 42 | 39.8 ± 36 | 0.77 |
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Endo, S.; Saisho, Y.; Miyakoshi, K.; Ochiai, D.; Matsumoto, T.; Kawano, Y.; Mitsuishi, M.; Irie, J.; Tanaka, M.; Meguro, S.; et al. Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis. J. Clin. Med. 2018, 7, 5. https://doi.org/10.3390/jcm7010005
Endo S, Saisho Y, Miyakoshi K, Ochiai D, Matsumoto T, Kawano Y, Mitsuishi M, Irie J, Tanaka M, Meguro S, et al. Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis. Journal of Clinical Medicine. 2018; 7(1):5. https://doi.org/10.3390/jcm7010005
Chicago/Turabian StyleEndo, Sho, Yoshifumi Saisho, Kei Miyakoshi, Daigo Ochiai, Tadashi Matsumoto, Yoshinaga Kawano, Masanori Mitsuishi, Junichiro Irie, Masami Tanaka, Shu Meguro, and et al. 2018. "Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis" Journal of Clinical Medicine 7, no. 1: 5. https://doi.org/10.3390/jcm7010005
APA StyleEndo, S., Saisho, Y., Miyakoshi, K., Ochiai, D., Matsumoto, T., Kawano, Y., Mitsuishi, M., Irie, J., Tanaka, M., Meguro, S., Tanaka, M., & Itoh, H. (2018). Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis. Journal of Clinical Medicine, 7(1), 5. https://doi.org/10.3390/jcm7010005