FOLFIRINOX Chemotherapy in Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis of Retrospective and Phase II Studies
1
Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada
2
Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada
3
Algoma District Cancer Program, Sault Area Hospital, Sault Ste. Marie, ON P6B 0A8, Canada
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(1), 7; https://doi.org/10.3390/jcm7010007
Received: 29 November 2017
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Revised: 18 December 2017
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Accepted: 21 December 2017
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Published: 4 January 2018
(This article belongs to the Section Oncology)
The introduction of the FOLFIRINOX regimen within the last decade marked the first progress in the clinical field of metastatic pancreatic cancer which had not seen any improvements in treatment availability for several years. In a phase III randomized clinical trial, FOLFIRINOX showed superior efficacy compared to the previous standard treatment of gemcitabine monotherapy. Nevertheless, it is unknown whether the superior results observed in this single phase III clinical trial can be translated more broadly to clinical practice. Our investigation sought to analyze all published evidence of the FOLFIRINOX regimen in series and phase II trials and compare it to the experience of the phase III study. Survival analysis revealed that FOLFIRINOX was associated with an Overall Survival of 10–11 months both in the trials and in off-trial settings, with response rates also similar in both settings. The adverse effect profile was consistent between the pooled phase II and off-trial experience and the FOLFIRINOX regimen arm observed in the randomized phase III trial.
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Keywords:
FOLFIRINOX; chemotherapy; pancreatic cancer; efficacy outcomes; adverse effects
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MDPI and ACS Style
Thibodeau, S.; Voutsadakis, I.A. FOLFIRINOX Chemotherapy in Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis of Retrospective and Phase II Studies. J. Clin. Med. 2018, 7, 7. https://doi.org/10.3390/jcm7010007
AMA Style
Thibodeau S, Voutsadakis IA. FOLFIRINOX Chemotherapy in Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis of Retrospective and Phase II Studies. Journal of Clinical Medicine. 2018; 7(1):7. https://doi.org/10.3390/jcm7010007
Chicago/Turabian StyleThibodeau, Stephane, and Ioannis A. Voutsadakis. 2018. "FOLFIRINOX Chemotherapy in Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis of Retrospective and Phase II Studies" Journal of Clinical Medicine 7, no. 1: 7. https://doi.org/10.3390/jcm7010007
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