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Open AccessFeature PaperCase Report

Clinical Remission of Cutaneous Squamous Cell Carcinoma of the Auricle with Cetuximab and Nivolumab

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Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
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Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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The Angeles Clinic and Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
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Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(1), 10; https://doi.org/10.3390/jcm7010010
Received: 19 December 2017 / Revised: 30 December 2017 / Accepted: 3 January 2018 / Published: 10 January 2018
(This article belongs to the Section Dermatology)
Cutaneous squamous cell carcinomas (SCC) affecting the regions of the head and neck can be challenging to resect surgically and refractory to chemotherapy or radiation therapy. Consequently; the treatment of squamous cell carcinomas of the skin is a focus of current research. One such advancement is immunotherapy. Herein we describe clinical remission of invasive, poorly differentiated squamous cell carcinoma of the pre-auricular region with external auditory canal involvement using cetuximab, an epidermal growth factor receptor (EGFR) antibody; and nivolumab, a programmed death receptor-1 (PD-1) antibody. Such durable and comprehensive disease resolution demonstrates the therapeutic potential of cetuximab and nivolumab in surgically challenging, treatment-resistant cutaneous squamous cell carcinoma. View Full-Text
Keywords: cutaneous squamous cell carcinoma; cetuximab; nivolumab cutaneous squamous cell carcinoma; cetuximab; nivolumab
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MDPI and ACS Style

Chen, A.; Ali, N.; Boasberg, P.; Ho, A.S. Clinical Remission of Cutaneous Squamous Cell Carcinoma of the Auricle with Cetuximab and Nivolumab. J. Clin. Med. 2018, 7, 10.

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