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J. Clin. Med. 2018, 7(1), 1; https://doi.org/10.3390/jcm7010001

Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview

1,2,†
,
1,†
,
1
,
1
,
1,3
and
1,3,*
1
Department of Anatomy and Cell Biology, East Carolina University, Greenville, NC 27834, USA
2
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA
3
Leo Jenkins Cancer Center, The Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 October 2017 / Revised: 30 November 2017 / Accepted: 11 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Epithelial-Mesenchymal Transition)
Full-Text   |   PDF [285 KB, uploaded 22 December 2017]

Abstract

The epithelial mesenchymal transition (EMT) plays a central role in both normal physiological events (e.g., embryonic development) and abnormal pathological events (e.g., tumor formation and metastasis). The processes that occur in embryonic development are often reactivated under pathological conditions such as oncogenesis. Therefore, defining the regulatory networks (both gene and protein levels) involved in the EMT during embryonic development will be fundamental in understanding the regulatory networks involved in tumor development, as well as metastasis. There are many molecules, factors, mediators and signaling pathways that are involved in the EMT process. Although the EMT is a very old topic with numerous publications, recent new technologies and discoveries give this research area some new perspective and direction. It is now clear that these important processes are controlled by a network of transcriptional and translational regulators in addition to post-transcriptional and post-translational modifications that amplify the initial signals. In this review article, we will discuss some key concepts, historical findings, as well as some recent progresses in the EMT research field. View Full-Text
Keywords: epithelial mesenchymal transition; embryonic development; tissue repair; tumor formation and progression; stem cells epithelial mesenchymal transition; embryonic development; tissue repair; tumor formation and progression; stem cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Kim, D.H.; Xing, T.; Yang, Z.; Dudek, R.; Lu, Q.; Chen, Y.-H. Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview. J. Clin. Med. 2018, 7, 1.

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